Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 33 - 59
Published: Nov. 29, 2024
Language: Английский
Deleted Journal, Journal Year: 2023, Volume and Issue: 1(4)
Published: Oct. 1, 2023
Abstract Liquid biopsy has emerged as a promising avenue for non‐invasive and rapid retrieval of pathological information from patient body fluids. Over the years, liquid garnered significant attention clinically treating cancer by selecting appropriate biomarkers such circulating tumor cells (CTCs) extracellular vesicles (EVs). Further integration advanced technologies facilitated efficient capture biopsy, revolutionizing clinical decision‐making in multiple processes stages patients. Underscoring intersection different disciplines, this review provides holistic summary recent breakthroughs specifically designed application distinctive to blend real‐world with material science. Firstly, we focus on main principles that facilitate release (e.g., CTCs EVs), leveraging their physicochemical properties. Then, applications are summarized, highlighting potential providing comprehensive information. Later, incorporation machine learning is also emphasized enhancing enabling deeper insights design next‐generation platforms specific biomarker isolation. Finally, future opportunities explored combining nanotechnologies artificial intelligence, thereby offering inconceivable possibilities improving care.
Language: Английский
Citations
48
Biotechnology Advances, Journal Year: 2024, Volume and Issue: 71, P. 108317 - 108317
Published: Jan. 13, 2024
Language: Английский
Citations
31
Science Advances, Journal Year: 2023, Volume and Issue: 9(40)
Published: Oct. 6, 2023
Small extracellular vesicles (sEVs; <200 nm) that contain lipids, nucleic acids, and proteins are considered promising biomarkers for a wide variety of diseases. Conventional methods sEV isolation from blood incompatible with routine clinical workflows, significantly hampering the utilization blood-derived sEVs in settings. Here, we present simple, viscoelastic-based microfluidic platform label-free human blood. The separation performance device is assessed by isolating fluorescent whole blood, demonstrating purities recovery rates over 97 87%, respectively. Significantly, our method also provides remarkable increase yield compared to gold-standard ultracentrifugation, proteomic profiles purified both showing similar protein compositions. To demonstrate utility approach, isolate samples 20 patients cancer healthy donors, elevated concentrations can be observed derived cancer.
Language: Английский
Citations
40
Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(4), P. 697 - 706
Published: Jan. 1, 2024
A cascaded elasto-inertial cell separation device for pretreatment-free, high-recovery-ratio, and high-purity of malignant tumor cells from clinical pleural peritoneal effusions.
Language: Английский
Citations
14
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8594 - 8594
Published: Aug. 6, 2024
Liquid biopsy, a noninvasive diagnosis that examines circulating tumor components in body fluids, is increasingly used cancer management. An overview of relevant literature emphasizes the current state liquid biopsy applications care. Biomarkers particularly DNA (ctDNA), RNAs (ctRNA), cells (CTCs), extracellular vesicles (EVs), and other components, offer promising opportunities for early diagnosis, treatment selection, monitoring, disease assessment. The implementation precision medicine has shown significant potential various types, including lung cancer, colorectal breast prostate cancer. Advances genomic molecular technologies such as next-generation sequencing (NGS) digital polymerase chain reaction (dPCR) have expanded utility enabling detection somatic variants actionable alterations tumors. also demonstrated predicting responses, monitoring minimal residual (MRD), assessing heterogeneity. Nevertheless, standardizing techniques, interpreting results, integrating them into clinical routine remain challenges. Despite these challenges, implications management, offering dynamic approach to understanding biology guiding personalized strategies.
Language: Английский
Citations
11
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159741 - 159741
Published: Jan. 1, 2025
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152531 - 152531
Published: May 24, 2024
Language: Английский
Citations
6
Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
Abstract In this work, an integrated biosensor consisting of spiral microfluidic array and microwave sensors is proposed for simultaneous separation detection cells. The by plasma processing technology fabricated soft lithography glass‐based IC process, which has the advantages simple preparation, low cost, reliable structure. field clinical medicine, Escherichia coli ( E. ) causative agent urinary tract infections, leads to increase in number white blood cells (WBCs) present urine. Different concentrations WBCs mixed solution are configured perform biological cell experiments capability separating detecting verified. Interdigital capacitors (IDCs) split ring resonators (SRRs) employed detect obtained separation. exhibits a WBC collection rate 92.7%. capacitance IDC resonant amplitude SRR exhibit decrease 51.36 pF 0.34 dB, demonstrates satisfactory linearity 0.96 0.98, respectively. Consequently, used simultaneously separate potential early diagnosis infections medicine.
Language: Английский
Citations
0
Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 278, P. 117359 - 117359
Published: March 11, 2025
Language: Английский
Citations
0
TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118240 - 118240
Published: March 1, 2025
Citations
0