Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.

Language: Английский

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Cuproptosis: Advances in Stimulus‐Responsive Nanomaterials for Cancer Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: April 15, 2024

Abstract Cuproptosis, a recently identified non‐apoptotic programmed cell death modality, attracts considerable attention in the realm of cancer therapeutics owing to its unique cellular demise mechanisms. Since initial report 2022, strategies inducing or amplifying cuproptosis for treatment emerge. The engineering nano‐systems elicit effectively circumvents constraints associated with conventional small‐molecule pharmaceutical interventions, presenting novel prospects oncological therapy. Stimulus‐responsive nanomaterials, leveraging their distinctive spatiotemporal control attributes, are investigated role modulating induction augmentation cuproptosis. In this comprehensive review, physiological characteristics cuproptosis, encompassing facets such as copper overload and depletion, coupled regulatory factors intrinsic expounded upon. Subsequently, design methodologies stimulus‐responsive enhancement employing stimuli light, ultrasound, X‐ray, tumor microenvironment, systematically delineated. This review encompasses intricacies nanomaterial design, insights into therapeutic processes, advantages. Finally, challenges inherent induction/enhancement deliberated upon prospective future trajectory copper‐mediated therapy provided.

Language: Английский

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Application of metal-based catalysts for Fenton reaction: from homogeneous to heterogeneous, from nanocrystals to single atom

Nano Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Language: Английский

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Metal ion interference therapy: metal-based nanomaterial-mediated mechanisms and strategies to boost intracellular “ion overload” for cancer treatment

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(18), P. 4275 - 4310

Published: Jan. 1, 2024

This comprehensive review systematically summarizes the intrinsic mechanism of different metal ion (such as Fe 3+ /Fe 2+ , Cu /Cu + Ca Zn Mn Na /K and Mg )-mediated interference therapies their research progress in cancer treatment.

Language: Английский

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Disulfiram-loaded CuO2 nanocarriers for enhanced synergistic chemodynamic chemotherapy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 674, P. 9 - 18

Published: June 21, 2024

Language: Английский

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DNA Logic Gate-Triggered Membrane Fusion for Accurately Detecting and Killing Cancer Cells

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Accurately and sensitively identifying killing cancer cells, especially those in deep tissues, is of paramount importance but presents significant challenges. Herein, a membrane protein adenosine triphosphate (ATP)-driven DNA logic gate-modified liposome designed to coat zinc peroxide (ZP) nanoparticles integrated with nanozymes (ZP/RuTe@L/DNA) accurately identify induce cell apoptosis cells through reactive oxygen species (ROS)-mediated mechanism under acid conditions cells. In this system, gate-functionalized liposomes are loaded ZP nanozymes, while HeLa functionalized segment that complementary the gate. For gate, aptamer was employed for recognition, another used response extracellular ATP. Activation gate occurs only when both biomarkers simultaneously present. Once activated, could hybridize segment-modified leading liposome-HeLa fusion release ZP/RuTe into Under conditions, decompose H2O2 Zn2+, which promote production •O2- by inhibiting electron transport chain. Concurrently, released RuTe exhibits glutathione (GSH) depletion peroxidase (POD) nicotinamide adenine dinucleotide (NADH) peroxidase-like activities, generating highly toxic hydroxyl radical (•OH), disrupting cellular redox homeostasis, inducing apoptosis. The ZP/RuTe@L/DNA system not detect complex mixtures also present novel method liposome-membrane processes drug delivery. This study potential application precise diagnosis therapy.

Language: Английский

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H₂O₂‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Tumor cells exploit abnormal redox homeostasis and the pro‐tumorigenic effect of reactive oxygen species (ROS) to enhance their survival progression. However, excessively high levels ROS can exceed oxidative stress threshold tumor cells, inducing cell death. This occur by selectively elevating concentration H 2 O in through both endogenous exogenous mechanisms. The generated serves as a precursor for toxic ROS, such • OH 1 , via chemodynamic photodynamic therapy, respectively, leading apoptosis, necrosis, ferroptosis. Strategies boost include direct delivery amplifying generation inhibiting antioxidant enzymes, leveraging glucose oxidase, employing photocatalytic therapy (PCT), utilizing metal peroxides. Among them, peroxides have displayed remarkable performance due excellent potential elevate within while simultaneously normalizing acidic hypoxic conditions microenvironment (TME). Moreover, these nanostructures sensitivity complementary treatments, like chemotherapy. review summarizes advanced perspectives design, synthesis, comparative analysis ‐generating nanoplatforms, emphasizing capacity treat various cancers.

Language: Английский

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In situ construction of heterojunctions to regulate the biodegradation behavior of copper carriers for tumor-specific cuproptosis-enhanced sono-immunotherapy

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 25, 2025

Cuproptosis, a novel approach utilizing copper carriers to trigger programmed cell death, exhibits promise for enhancing traditional therapies and activating robust adaptive immune responses. However, the uncontrolled release of Cu ions risks triggering cuproptosis in healthy tissues, potentially causing irreversible damage. To address this, we report on use Cu-MOF (copper metal-organic framework) protective layer regulate biodegradation copper-based nanomaterials. In situ formation Cu2O nanocubes not only stabilizes material under physiological conditions but also enhances its sonodynamic therapy (SDT) capabilities by establishing Z-Scheme heterojunction. Upon SDT activation, targeted ion at tumor site triggers cascade reactions, generating reactive oxygen species (ROS) via Fenton-like processes depleting glutathione (GSH). This ROS surge, combined with effective cuproptosis, modulates immunosuppressive microenvironment, inducing immunogenic death eliminate primary tumors inhibit metastasis. study offers new paradigm controlled integration SDT, chemodynamic (CDT), immunotherapy, achieving precise tumor-targeted treatment nanomaterial degradation.

Language: Английский

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Engineering Dual-Responsive Nanoplatform Achieves Copper Metabolism Disruption and Glutathione Consumption to Provoke Cuproptosis/Ferroptosis/Apoptosis for Cancer Therapy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Cuproptosis is a new copper-dependent form of regulated cell death and shows enormous promise in cancer therapy. However, its therapeutic performance compromised by the strictly copper metabolism highly expressed intracellular glutathione (GSH). Herein, an intelligent nanoplatform (NSeMON-P@CuT/LipD) rationally developed as metabolic disrupter, GSH consumer, Fenton-like reaction trigger for cuproptosis/ferroptosis/apoptosis NSeMON-P@CuT/LipD constructed from preparation diselenide-bridged mesoporous organosilica nanoparticles, then pemetrexed (Pem) loaded followed surface deposition with Cu2+-3,3′-dithiobis(propionohydrazide) (TPH) coordinated network coating diclofenac (DC)-encapsulated liposome. In response to specific tumor microenvironment, obtained can release DC, Cu2+, Pem simultaneously amplify cellular oxidative stress consuming catalyzing endogenous H2O2 into hydroxyl radicals (•OH). Both liberated DC augmented inhibit glycolysis, reduce ATP level, block transporter ATP7B, resulting disorders high retention cells •OH generation. Moreover, overloaded promote dihydrolipoamide S-acetyltransferase oligomerization Fe–S cluster protein loss, thus evoking cuproptosis. Collectively, activates prominent ferroptosis, which cooperates cuproptosis Pem-mediated apoptosis significantly growth 4T1 tumor-bearing mice. This study demonstrates feasible strategies enhance using single may also inspire design advanced cuproptosis-related therapies.

Language: Английский

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Fenton-like nanoparticles capable of H₂O₂ self-supply and glutathione consumption for chemodynamic and chemotherapy of cancer

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(21), P. 5534 - 5546

Published: Jan. 1, 2024

Chemodynamic therapy (CDT) utilizing the Fenton reaction to convert hydrogen peroxide (H2O2) into cytotoxic hydroxyl radicals (˙OH) has recently drawn extensive interest in tumor treatment. However, therapeutic efficiency of CDT often suffers from high concentrations glutathione (GSH), insufficient endogenous H2O2 and inefficient activity. Herein, a GSH-depleting self-providing nanosystem that can efficiently load copper ions doxorubicin (DOX) (MSN-Cu2+-DOX) induce enhanced chemotherapy is proposed. The results show MSN-Cu2+-DOX could release Cu2+ DOX under acidic conditions. Particularly, both released are available for ˙OH production via Fenton-like CDT. Meanwhile, undergoes reduction Cu+ by depleting overexpressed GSH, thereby enhancing Moreover, not only be used chemotherapy, but also promote generation improve Cu-based reaction. Resultantly, this featuring activity, GSH consumption, self-sufficiency exhibits great antitumor effect with inhibition ratio 93.05%. Overall, study provides promising strategy enhance effective therapy.

Language: Английский

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