Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(28)
Published: March 8, 2024
We
report
the
synthesis
of
a
series
amphiphilic
p-sulfonatocalix[4]arenes
with
varying
alkyl
chain
lengths
(CX4-Cn)
and
their
application
as
efficient
counterion
activators
for
membrane
transport
cell-penetrating
peptides
(CPPs).
The
enhanced
activity
is
confirmed
carboxyfluorescein
(CF)
assay
in
vesicles
by
direct
cytosolic
delivery
CPPs
into
CHO-K1,
HCT
116,
KTC-1
cells
enabling
excellent
cellular
uptake
two
cancer
cell
lines.
Intracellular
was
fluorescence
microscopy
after
CPP
entry
live
mediated
CX4-Cn,
which
also
quantified
lysis
spectroscopy.
results
present
first
systematic
exploration
structure-activity
relationships
calixarene-based
show
that
CX4-Cn
are
exceptionally
effective
CPPs.
dodecyl
derivative,
CX4-C12,
serves
best
activator.
A
mechanistic
insight
provided
at
4
°C
presence
endocytosis
inhibitor
dynasore,
indicates
translocation
CPP-counterion
complexes
cytosol
highlights
potential
benefits
CPP-conjugated
cargo
molecules
cells.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(9), P. 5505 - 5616
Published: April 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(10), P. 9497 - 9570
Published: March 31, 2022
In-cell
structural
biology
aims
at
extracting
information
about
proteins
or
nucleic
acids
in
their
native,
cellular
environment.
This
emerging
field
holds
great
promise
and
is
already
providing
new
facts
outlooks
of
interest
both
fundamental
applied
levels.
NMR
spectroscopy
has
important
contributions
on
this
stage:
It
brings
a
broad
variety
nuclei
the
atomic
scale,
which
ensures
its
versatility
uniqueness.
Here,
we
detail
methods,
knowledge,
applications
biomedical
engineering
related
to
in-cell
by
NMR.
We
finally
propose
brief
overview
main
other
techniques
(EPR,
smFRET,
cryo-ET,
etc.)
draw
some
advisable
developments
for
In
era
large-scale
screenings
deep
learning,
accurate
qualitative
experimental
evidence
are
as
essential
ever
understand
interior
life
cells.
can
generate
such
it
does
so
scale.
review
meant
deliver
comprehensive
but
accessible
information,
with
advanced
technical
details
reflections
nature
results,
future
field.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(12), P. 7782 - 7853
Published: May 15, 2023
The
high
selectivity
and
affinity
of
antibodies
toward
their
antigens
have
made
them
a
highly
valuable
tool
in
disease
therapy,
diagnosis,
basic
research.
A
plethora
chemical
genetic
approaches
been
devised
to
make
accessible
more
"undruggable"
targets
equipped
with
new
functions
illustrating
or
regulating
biological
processes
precisely.
In
this
Review,
addition
introducing
how
naked
various
antibody
conjugates
(such
as
antibody-drug
conjugates,
antibody-oligonucleotide
antibody-enzyme
etc.)
work
therapeutic
applications,
special
attention
has
paid
chemistry
tools
helped
optimize
the
outcome
(i.e.,
enhanced
efficacy
reduced
side
effects)
facilitate
multifunctionalization
antibodies,
focus
on
emerging
fields
such
targeted
protein
degradation,
real-time
live-cell
imaging,
catalytic
labeling
decaging
spatiotemporal
control
well
engagement
inside
cells.
With
advances
modern
biotechnology,
well-designed
derivatives
via
size
miniaturization
together
efficient
delivery
systems
emerged,
which
gradually
improved
our
understanding
important
paved
way
pursue
novel
for
potential
treatments
diseases.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
A
biodegradable
and
biocompatible
micellar-based
drug
delivery
system
was
developed
using
amphiphilic
methoxy-poly(ethylene
glycol)-cholesterol
(C1)
poly(ethylene
glycol)-S-S-cholesterol
(C2)
conjugates
applied
to
the
tumoral
release
of
water-insoluble
curcumin.
These
synthesized
surfactants
C1
C2
were
found
form
stable
micelles
(CMC
∼
6
μM)
an
average
hydrodynamic
size
around
20-25
nm.
The
curcumin-encapsulated
micelle
formulated
by
a
solvent
evaporation
method.
very
high
encapsulation
efficiency
(EE)
∼88%
loading
(DL)
capacity
∼9%
determined
for
both
micelles.
From
reduced
rate
curcumin
degradation
differential
scanning
calorimetry
(DSC)
analysis,
stability
curcumin-loaded
be
higher
than
that
unloaded
micelle,
which
confirmed
more
compact
structural
arrangement
in
presence
hydrophobic
pH-sensitive
(faster
with
decrease
pH)
observed
attributed
diffusion
relaxation/erosion
micellar
aggregates.
To
achieve
reduction
environment-sensitive
release,
disulfide
(S-S)
chemical
linkage-incorporated
mPEG-cholesterol
conjugate
synthesized,
show
glutathione-responsive
faster
vitro
experiments
carried
out
SCC9
oral
cancer
cell
lines
showed
blank
noncytotoxic
at
lower
concentrations
(<50
μM),
while
inhibited
proliferation
promoted
apoptosis.
An
increased
cytotoxicity
compared
itself,
demonstrating
better
penetration
efficacy
micelle.
results
further
supplemented
vivo
anticancer
analysis
formulations
mice
xenograft
model.
Notably,
significantly
stronger
apoptotic
effect
micelles,
indicating
GSH
improved
bioavailability.
In
conclusion,
advantages
small
size,
efficiency,
loading,
simple
preparing
technique,
biocompatibility,
good
performance
may
have
potential
used
as
carrier
sustained
stimuli-responsive
Smart Materials in Medicine,
Journal Year:
2023,
Volume and Issue:
4, P. 447 - 459
Published: Jan. 1, 2023
Silk
sericin
(SS)
is
a
byproduct
of
the
silk
production
process
that
consists
18
amino
acids
and
numerous
polar
groups.
SS
has
range
unique
physical,
chemical,
biological
properties,
such
as
mechanical
strength,
antioxidant
activity,
pH
responsiveness,
low
immunogenicity,
biocompatibility,
ability
to
promote
cell
proliferation.
These
properties
make
useful
in
various
fields,
including
food
biomedicine.
It
can
also
be
easily
modified
into
biomaterials
through
cross-linking,
copolymerization,
combination
with
other
polymers.
This
review
summarizes
potential
applications
SS-based
biomedicine
industries,
additives,
packaging,
vitro/vivo
monitoring,
drug
delivery
systems,
wound
healing.
In
addition,
future
development
possibilities
or
are
discussed.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(25)
Published: Aug. 3, 2023
Anthocyanin,
a
unique
natural
polyphenol,
is
abundant
in
plants
and
widely
utilized
biomedicine,
cosmetics,
the
food
industry
due
to
its
excellent
antioxidant,
anticancer,
antiaging,
antimicrobial,
anti-inflammatory
properties.
However,
degradation
of
anthocyanin
an
extreme
environment,
such
as
alkali
pH,
high
temperatures,
metal
ions,
limits
physiochemical
stabilities
bioavailabilities.
Encapsulation
combining
with
biomaterials
could
efficiently
stabilize
for
protection.
Promisingly,
or
artificially
designed
proteins
peptides
favorable
stabilities,
biocapacity,
wide
sources
are
potential
candidates
anthocyanin.
This
review
focuses
on
recent
progress,
strategies,
perspectives
protein
peptide
functionalization
delivery,
i.e.,
formulation
technologies,
physicochemical
stability
enhancement,
cellular
uptake,
bioavailabilities,
biological
activities
development.
Interestingly,
simplicity
diversity
structure,
interaction
mechanisms
between
be
illustrated.
work
sheds
light
mechanism
protein/peptide-anthocyanin
nanoparticle
construction
expands
applications
nutrition
biomedicine.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
31, P. 206 - 230
Published: Aug. 14, 2023
Traditional
cancer
therapy
methods,
especially
those
directed
against
specific
intracellular
targets
or
signaling
pathways,
are
not
powerful
enough
to
overcome
tumor
heterogeneity
and
therapeutic
resistance.
Oncolytic
peptides
that
can
induce
membrane
lysis-mediated
cell
death
subsequent
anticancer
immune
responses,
has
provided
a
new
paradigm
for
therapy.
However,
the
clinical
application
of
oncolytic
is
always
limited
by
some
factors
such
as
unsatisfactory
bio-distribution,
poor
stability,
off-target
toxicity.
To
these
limitations,
polymers
stand
out
prospective
materials
owing
their
high
chemical
versatility,
scalable
production
capacity,
which
potential
drive
revolution
in
treatment.
This
review
provides
an
overview
mechanism
structure-activity
relationship
peptides.
Then
peptides-mediated
combination
nano-delivery
strategies
summarized.
Emphatically,
current
research
progress
been
highlighted.
Lastly,
challenges
prospects
development
discussed.
Journal of Composites Science,
Journal Year:
2024,
Volume and Issue:
8(1), P. 28 - 28
Published: Jan. 11, 2024
Cancer
therapy
currently
focuses
on
personalized
targeted
treatments.
A
promising
approach
uses
stimuli-responsive
biomaterials
for
site-specific
drug
release,
such
as
pH-
and
redox-triggered
polymer
nanocomposites.
These
materials
respond
to
the
tumor
microenvironment,
enhance
efficacy,
reduce
off-target
effects.
cells
with
anomalous
properties
acidic
cytosolic
pH
elevated
redox
potential
are
by
these
biomaterials.
An
imbalance
in
ions
biological
thiols
cytoplasm
contributes
growth.
Functionalized
nanocomposites
large
surface
areas
specific
targeting
outperform
conventional
small-molecule
materials.
To
overcome
problems
low
bioavailability,
uncontrolled
poor
cell
penetration,
multifunctional
nanomaterials
make
it
easier
drugs
enter
certain
cellular
or
subcellular
systems.
High
therapeutic
efficacy
is
achieved
through
functionalization,
targeting,
use
of
components.
In
particular,
dual-stimuli-based
polymeric
cancer
therapeutics
have
scarcely
been
reported.
This
article
provides
recent
progress
redox-responsive
delivery
therapy.
It
explores
design
principles,
fabrication
methods,
mechanisms
action,
prospects
dual-stimuli-responsive
