Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(8), P. 2617 - 2642
Published: Jan. 1, 2023
Glycomacromolecules show significant potential as antimicrobials. We highlight recent studies on their performance in hindering host cell entry and biofilm formation, drug delivery diagnostic agents.
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)
Published: June 22, 2024
Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.
Language: Английский
Citations
39
Progress in Materials Science, Journal Year: 2024, Volume and Issue: 143, P. 101248 - 101248
Published: Feb. 11, 2024
Language: Английский
Citations
19
Small, Journal Year: 2024, Volume and Issue: 20(26)
Published: Jan. 12, 2024
Abstract Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects BCs. NCs equally as BCs some extent. Self‐assembly (SA) methods build advantages than chemical methods, and SA significant impact on structure function NCs. However, relationship among mechanism, structure, not been given enough attention. Therefore, from perspective bottom‐up building concept SA‐structure‐function is emphasized promote SA‐based First, conditions forces for occurring introduced, then basis molecular mechanism protein, polysaccharide, lipid summarized. Then, varieties structures formed based introduced in detail. Finally, facing how be well solved by also elaborated. This review attempts describe great significance constructing artificial deliver aspects SA‐structure‐function, so wide application
Language: Английский
Citations
18
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132123 - 132123
Published: May 17, 2024
Language: Английский
Citations
18
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.
Language: Английский
Citations
3
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 138 - 174
Published: Feb. 5, 2025
Language: Английский
Citations
2
Macromolecules, Journal Year: 2022, Volume and Issue: 55(12), P. 4867 - 4890
Published: June 8, 2022
Glycopolymers are synthetic polymers with pendant sugars, which hold promise for a range of biomedical applications ranging from tissue engineering to sensing. The known specific interaction glycopolymers lectins has inspired researchers use these deliver drugs cells that overexpress lectin receptors. As result, many glycopolymers─based on mannose, galactose, fructose, or other saccharides–have been used the targeted delivery drugs, traditional anticancer nucleic acid-derived therapeutics. For drug purposes, typically processed into nanoparticles form matrix entrap safely, such as micelles, polyplexes, polyion complex nanosized carriers. In vitro and in vivo studies have shown can indeed be delivered selectively by leveraging selective recognition surface bound lectins. key between is presence strong intermolecular forces hydrogen bonding. formation bonds can, however, also one drawbacks materials. tend self-aggregate, they interact unexpected ways, bind proteins nonspecific manner. Despite challenges, based might offer possibilities cannot replicated water-soluble polymers. They already effectively vivo, though more preclinical necessary enable their broader clinical uptake. Further focus could directed at an improved understanding interface biological surrounding improve targeting ability vivo. this Perspective, I will discuss aspects consider when preparing carrier using glycopolymers. This include glyconanoparticles resulting property changes, types suitable delivery, effect nanoparticle structure affinity cell GLUT transporters promising results show delivery.
Language: Английский
Citations
55
Topics in Current Chemistry, Journal Year: 2022, Volume and Issue: 380(5)
Published: Aug. 11, 2022
Language: Английский
Citations
54
Chemistry - A European Journal, Journal Year: 2022, Volume and Issue: 28(67)
Published: Sept. 8, 2022
Polymer alternatives sourced from nature have attracted increasing attention for applications in medicine, cosmetics, agriculture, food, water purification, and more. Among them, chitosan is the most versatile due to its full biodegradability, exceptional biocompatibility, multipurpose bioactivity, low toxicity. Although remarkable progress has been made synthetic modification by using C3/C6 secondary/primary hydroxy (-OH) C2 amino (-NH2 ) active sites, solubility under physiological conditions remains limited hampered larger-scale adoption. This review summarizes different methods that increase chitosan's hydrophilicity covalent modifications, namely acid addition, quaternary ammonium formation, phosphorylation, carboxymethylation. We also several each type of substitution fields such as provide an outlook perspective future modifications implementations.
Language: Английский
Citations
51
Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(44), P. 20137 - 20152
Published: Sept. 8, 2022
Mucus hydrogels at biointerfaces are crucial for protecting against foreign pathogens and the biological functions of underlying cells. Since mucus can bind to host both viruses bacteria, establishing a synthetic model system that emulate properties native be synthesized large scale would revolutionize mucus-related research is essential understanding pathways many infectious diseases. The synthesis such biofunctional in laboratory highly challenging, owing their complex chemical compositions specific interactions occur throughout gel network. In this perspective, we discuss basic structures diverse physicochemical responsible unique hydrogels. We scrutinize different approaches preparing mucus-inspired hydrogels, with examples. also recent what it reveals about challenges must addressed opportunities considered achieve desirable de novo
Language: Английский
Citations
51