Separations,
Journal Year:
2024,
Volume and Issue:
11(8), P. 233 - 233
Published: July 29, 2024
Peptides
are
gaining
prominence
in
various
fields,
including
the
pharmaceutical
industry.
To
meet
regulatory
requirements,
they
must
achieve
a
certain
purity
threshold
to
ensure
safe
administration.
Numerous
purification
technologies
have
been
employed
purify
peptides,
aiming
reduce
cost
and
time
while
being
sustainable
efficient.
These
include
chromatography,
magnetic
nanoparticles,
isoelectric
focusing,
membrane
filtration.
The
physicochemical
properties
of
peptides
main
driving
element
behind
these
technologies.
While
chromatographic
separation
remains
gold
standard
for
peptide
purification,
with
models
predict
elution
behaviors
other
demonstrated
their
capability
performance
established
methodologies,
better
productivity
reduced
cost.
This
opens
door
further
investigational
studies
assess
outcomes
potentially
introduce
new
techniques
purification.
In
this
review,
we
examine
terms
efficiency
ability
sustainability
concluding
remarks
an
outlook
on
future
advancements.
Journal of Peptide Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 17, 2024
Peptides
exhibit
significant
specificity
and
effective
interaction
with
therapeutic
targets,
positioning
themselves
as
key
players
in
the
global
pharmaceutical
market.
They
offer
potential
treatments
for
a
wide
range
of
diseases,
including
those
that
pose
challenges.
Notably,
peptide
trofinetide
(Daybue)
marked
groundbreaking
achievement
by
providing
first-ever
cure
Rett
syndrome,
several
peptides
have
secured
FDA
approval
first-in-class
medications.
Furthermore,
are
expanding
their
presence
areas
traditionally
dominated
either
small
or
large
molecules.
A
noteworthy
example
is
motixafortide
(Aphexda)
first
peptide-based
chemokine
antagonist.
Here,
focus
will
be
on
analysis
FDA-approved
peptides,
particularly
targeting
cardiovascular
human
immunodeficiency,
central
nervous
system
various
other
intriguing
classes
addressing
conditions
such
osteoporosis,
thrombocytopenia,
Cushing's
disease,
hypoglycemia,
among
others.
The
review
explore
chemical
structures
indications
modes
action,
developmental
trajectory,
adverse
effects.
Separations,
Journal Year:
2024,
Volume and Issue:
11(8), P. 233 - 233
Published: July 29, 2024
Peptides
are
gaining
prominence
in
various
fields,
including
the
pharmaceutical
industry.
To
meet
regulatory
requirements,
they
must
achieve
a
certain
purity
threshold
to
ensure
safe
administration.
Numerous
purification
technologies
have
been
employed
purify
peptides,
aiming
reduce
cost
and
time
while
being
sustainable
efficient.
These
include
chromatography,
magnetic
nanoparticles,
isoelectric
focusing,
membrane
filtration.
The
physicochemical
properties
of
peptides
main
driving
element
behind
these
technologies.
While
chromatographic
separation
remains
gold
standard
for
peptide
purification,
with
models
predict
elution
behaviors
other
demonstrated
their
capability
performance
established
methodologies,
better
productivity
reduced
cost.
This
opens
door
further
investigational
studies
assess
outcomes
potentially
introduce
new
techniques
purification.
In
this
review,
we
examine
terms
efficiency
ability
sustainability
concluding
remarks
an
outlook
on
future
advancements.
