Molecular Psychiatry,
Journal Year:
2023,
Volume and Issue:
28(9), P. 3625 - 3637
Published: Sept. 1, 2023
Abstract
The
human
body
harbors
a
diverse
ecosystem
of
microorganisms,
including
bacteria,
viruses,
and
fungi,
collectively
known
as
the
microbiota.
Current
research
is
increasingly
focusing
on
potential
association
between
microbiota
various
neuropsychiatric
disorders.
resides
in
parts
body,
such
oral
cavity,
nasal
passages,
lungs,
gut,
skin,
bladder,
vagina.
gut
gastrointestinal
tract
has
received
particular
attention
due
to
its
high
abundance
role
psychiatric
neurodegenerative
However,
presents
other
tissues,
though
less
abundant,
also
plays
crucial
immune
system
homeostasis,
thus
influencing
development
progression
For
example,
imbalance
associated
periodontitis
might
increase
risk
for
Additionally,
studies
using
postmortem
brain
samples
have
detected
widespread
presence
bacteria
brains
patients
with
Alzheimer’s
disease.
This
article
provides
an
overview
emerging
host
disorders
discusses
future
directions,
underlying
biological
mechanisms,
reliable
biomarkers
microbiota,
microbiota-targeted
interventions,
this
field.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(21), P. 6578 - 6578
Published: Nov. 1, 2024
Colorectal
cancer
(CRC)
constitutes
a
significant
global
health
challenge,
with
recent
studies
underscoring
the
pivotal
role
of
gut
microbiome
in
its
pathogenesis
and
progression.
Fecal
microbiota
transplantation
(FMT)
has
emerged
as
compelling
therapeutic
approach,
offering
potential
to
modulate
microbial
composition
optimize
treatment
outcomes.
Research
suggests
that
specific
bacterial
strains
are
closely
linked
CRC,
influencing
both
clinical
management
interventions.
Moreover,
microbiome's
impact
on
immunotherapy
responsiveness
heralds
new
avenues
for
personalized
medicine.
Despite
promise
FMT,
safety
concerns,
particularly
immunocompromised
individuals,
remain
critical
issue.
Clinical
outcomes
vary
widely,
influenced
by
genetic
predispositions
methodologies
employed.
Additionally,
rigorous
donor
selection
screening
protocols
paramount
minimize
risks
maximize
efficacy.
The
current
body
literature
advocates
establishment
standardized
further
trials
substantiate
FMT's
CRC
management.
As
our
understanding
deepens,
FMT
is
poised
become
cornerstone
treatment,
imperative
continued
research
validation.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(20), P. 11242 - 11347
Published: Oct. 9, 2024
Biopsy,
including
tissue
and
liquid
biopsy,
offers
comprehensive
real-time
physiological
pathological
information
for
disease
detection,
diagnosis,
monitoring.
Fluorescent
probes
are
frequently
selected
to
obtain
adequate
on
processes
in
a
rapid
minimally
invasive
manner
based
their
advantages
biopsy.
However,
conventional
fluorescent
have
been
found
show
aggregation-caused
quenching
(ACQ)
properties,
impeding
greater
progresses
this
area.
Since
the
discovery
of
aggregation-induced
emission
luminogen
(AIEgen)
promoted
advancements
molecular
bionanomaterials
owing
unique
high
quantum
yield
(QY)
signal-to-noise
ratio
(SNR),
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 270 - 270
Published: Feb. 12, 2025
The
gut-brain-cancer
axis
represents
a
novel
and
intricate
connection
between
the
gut
microbiota,
neurobiology,
cancer
progression.
Recent
advances
have
accentuated
significant
role
of
microbiota
metabolites
in
modulating
systemic
processes
that
influence
both
brain
health
tumorigenesis.
This
paper
explores
emerging
concept
metabolite-mediated
modulation
within
connection,
focusing
on
key
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
derivatives,
secondary
bile
acids,
lipopolysaccharides
(LPS).
While
microbiota's
impact
immune
regulation,
neuroinflammation,
tumor
development
is
well
established,
gaps
remain
grasping
how
specific
contribute
to
neuro-cancer
interactions.
We
discuss
with
potential
implications
for
neurobiology
cancer,
indoles
polyamines,
which
yet
be
extensively
studied.
Furthermore,
we
review
preclinical
clinical
evidence
linking
dysbiosis,
altered
metabolite
profiles,
tumors,
showcasing
limitations
research
gaps,
particularly
human
longitudinal
studies.
Case
studies
investigating
microbiota-based
interventions,
including
dietary
changes,
fecal
transplantation,
probiotics,
demonstrate
promise
but
also
indicate
hurdles
translating
these
findings
therapies.
concludes
call
standardized
multi-omics
approaches
bi-directional
frameworks
integrating
microbiome,
neuroscience,
oncology
develop
personalized
therapeutic
strategies
patients.
Microbial Biotechnology,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: Jan. 1, 2025
Using
synthetic
biology
techniques,
bacteria
have
been
engineered
to
serve
as
microrobots
for
diagnosing
diseases
and
delivering
treatments.
These
can
be
used
individually
or
in
combination
microbial
consortia.
The
components
within
these
consortia
complement
each
other,
enhancing
diagnostic
accuracy
providing
synergistic
effects
that
improve
treatment
efficacy.
application
of
therapies
cancer,
intestinal
diseases,
metabolic
disorders
underscores
their
significant
potential.
impact
on
the
host's
native
microbiota
is
crucial,
microbes
modulate
interact
with
environment,
influencing
outcomes
overall
health.
Despite
numerous
advancements,
challenges
remain.
include
ensuring
long-term
survival
safety
bacteria,
developing
new
chassis
gene
editing
techniques
non-model
strains,
minimising
potential
toxicity,
understanding
bacterial
interactions
host
microbiota.
This
mini-review
examines
current
state
disease
diagnosis
treatment,
highlighting
challenges,
future
directions
this
promising
field.
Medicine,
Journal Year:
2025,
Volume and Issue:
104(8), P. e41555 - e41555
Published: Feb. 21, 2025
The
onset
of
dental
caries
is
associated
with
multiple
factors,
including
oral
microbiota,
dietary
sugars,
the
defensive
mechanisms
saliva
and
teeth,
hygiene
practices,
socioeconomic
factors.
However,
its
relationship
gut
microbiota
remains
to
be
further
explored.
It
crucial
establish
a
definitive
causal
link
between
development
caries.
This
study
aimed
investigate
risk
caries,
focusing
on
identifying
specific
microbial
communities
potentially
implicated
in
pathogenesis.
Gut
data
from
genome-wide
association
studies
(GWAS)
conducted
by
MiBioGen
consortium
were
utilized
as
exposure
variable,
outcome
variable.
A
Mendelian
randomization
(MR)
approach
was
employed,
leveraging
comprehensive,
publicly
available
GWAS
summary
European
populations.
primary
analytical
method
inverse
variance
weighted
method,
supplemented
additional
techniques
such
median
model,
MR-Egger,
simple
mode,
ensure
robustness
results.
Heterogeneity
evaluated
using
Cochran
Q
test,
potential
pleiotropy
assessed
through
MR-Egger
regression.
Sensitivity
analyses
performed
leave-one-out
validate
findings.
results
revealed
that
higher
relative
abundance
Christensenellaceae,
FamilyXIII,
Ruminococcaceae,
Senegalimassilia
reduced
In
contrast,
Erysipelotrichia,
Erysipelotrichales,
Pasteurellales,
Erysipelotrichaceae,
Pasteurellaceae,
Methanobrevibacter,
Roseburia,
Terrisporobacter
linked
an
elevated
provides
compelling
evidence
for
offering
novel
insights
into
role
pathogenesis
European Journal of Preventive Cardiology,
Journal Year:
2023,
Volume and Issue:
30(12), P. 1274 - 1282
Published: May 17, 2023
Abstract
Aims
Studies
have
linked
gut
microbiome
and
heart
failure
(HF).
However,
their
causal
relationships
potential
mediating
factors
not
been
well
defined.
To
investigate
the
between
HF
effect
of
blood
lipids
by
using
genetics.
Methods
results
We
performed
a
bidirectional
mediation
Mendelian
randomization
(MR)
study
summary
statistics
from
genome-wide
association
studies
microbial
taxa
(Dutch
Microbiome
Project,
n
=
7738),
(UK
Biobank,
115
078),
meta-analysis
(115
150
cases
1550
331
controls).
applied
inverse–variance
weighted
estimation
method
as
primary
method,
with
several
other
estimators
complementary
methods.
The
multivariable
MR
approach
based
on
Bayesian
model
averaging
(MR-BMA)
was
used
to
prioritize
most
likely
lipids.
Six
are
suggestively
associated
causally.
significant
taxon
species
Bacteroides
dorei
[odds
ratio
1.059,
95%
confidence
interval
(CI)
1.022–1.097,
P-value
0.0017].
MR-BMA
analysis
showed
that
apolipoprotein
B
(ApoB)
lipid
for
(the
marginal
inclusion
probability
0.717,
0.005).
ApoB
mediated
effects
B.
(proportion
10.1%,
CI
0.2–21.6%,
0.031).
Conclusion
suggested
relationship
specific
might
mediate
this
determinant
HF.
