Microbiology and Molecular Biology Reviews, Journal Year: 2024, Volume and Issue: 88(2)
Published: March 20, 2024
SUMMARYThe genus
Language: Английский
Microbiological Research, Journal Year: 2023, Volume and Issue: 273, P. 127414 - 127414
Published: May 20, 2023
Language: Английский
Citations
71
Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(9), P. 3625 - 3637
Published: Sept. 1, 2023
Abstract The human body harbors a diverse ecosystem of microorganisms, including bacteria, viruses, and fungi, collectively known as the microbiota. Current research is increasingly focusing on potential association between microbiota various neuropsychiatric disorders. resides in parts body, such oral cavity, nasal passages, lungs, gut, skin, bladder, vagina. gut gastrointestinal tract has received particular attention due to its high abundance role psychiatric neurodegenerative However, presents other tissues, though less abundant, also plays crucial immune system homeostasis, thus influencing development progression For example, imbalance associated periodontitis might increase risk for Additionally, studies using postmortem brain samples have detected widespread presence bacteria brains patients with Alzheimer’s disease. This article provides an overview emerging host disorders discusses future directions, underlying biological mechanisms, reliable biomarkers microbiota, microbiota-targeted interventions, this field.
Language: Английский
Citations
51
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(21), P. 6578 - 6578
Published: Nov. 1, 2024
Colorectal cancer (CRC) constitutes a significant global health challenge, with recent studies underscoring the pivotal role of gut microbiome in its pathogenesis and progression. Fecal microbiota transplantation (FMT) has emerged as compelling therapeutic approach, offering potential to modulate microbial composition optimize treatment outcomes. Research suggests that specific bacterial strains are closely linked CRC, influencing both clinical management interventions. Moreover, microbiome's impact on immunotherapy responsiveness heralds new avenues for personalized medicine. Despite promise FMT, safety concerns, particularly immunocompromised individuals, remain critical issue. Clinical outcomes vary widely, influenced by genetic predispositions methodologies employed. Additionally, rigorous donor selection screening protocols paramount minimize risks maximize efficacy. The current body literature advocates establishment standardized further trials substantiate FMT's CRC management. As our understanding deepens, FMT is poised become cornerstone treatment, imperative continued research validation.
Language: Английский
Citations
26
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Sept. 23, 2024
Language: Английский
Citations
19
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(20), P. 11242 - 11347
Published: Oct. 9, 2024
Biopsy, including tissue and liquid biopsy, offers comprehensive real-time physiological pathological information for disease detection, diagnosis, monitoring. Fluorescent probes are frequently selected to obtain adequate on processes in a rapid minimally invasive manner based their advantages biopsy. However, conventional fluorescent have been found show aggregation-caused quenching (ACQ) properties, impeding greater progresses this area. Since the discovery of aggregation-induced emission luminogen (AIEgen) promoted advancements molecular bionanomaterials owing unique high quantum yield (QY) signal-to-noise ratio (SNR),
Language: Английский
Citations
17
Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)
Published: Jan. 1, 2025
Using synthetic biology techniques, bacteria have been engineered to serve as microrobots for diagnosing diseases and delivering treatments. These can be used individually or in combination microbial consortia. The components within these consortia complement each other, enhancing diagnostic accuracy providing synergistic effects that improve treatment efficacy. application of therapies cancer, intestinal diseases, metabolic disorders underscores their significant potential. impact on the host's native microbiota is crucial, microbes modulate interact with environment, influencing outcomes overall health. Despite numerous advancements, challenges remain. include ensuring long-term survival safety bacteria, developing new chassis gene editing techniques non-model strains, minimising potential toxicity, understanding bacterial interactions host microbiota. This mini-review examines current state disease diagnosis treatment, highlighting challenges, future directions this promising field.
Language: Английский
Citations
3
PharmaNutrition, Journal Year: 2025, Volume and Issue: unknown, P. 100435 - 100435
Published: Feb. 1, 2025
Language: Английский
Citations
2
Medicine, Journal Year: 2025, Volume and Issue: 104(8), P. e41555 - e41555
Published: Feb. 21, 2025
The onset of dental caries is associated with multiple factors, including oral microbiota, dietary sugars, the defensive mechanisms saliva and teeth, hygiene practices, socioeconomic factors. However, its relationship gut microbiota remains to be further explored. It crucial establish a definitive causal link between development caries. This study aimed investigate risk caries, focusing on identifying specific microbial communities potentially implicated in pathogenesis. Gut data from genome-wide association studies (GWAS) conducted by MiBioGen consortium were utilized as exposure variable, outcome variable. A Mendelian randomization (MR) approach was employed, leveraging comprehensive, publicly available GWAS summary European populations. primary analytical method inverse variance weighted method, supplemented additional techniques such median model, MR-Egger, simple mode, ensure robustness results. Heterogeneity evaluated using Cochran Q test, potential pleiotropy assessed through MR-Egger regression. Sensitivity analyses performed leave-one-out validate findings. results revealed that higher relative abundance Christensenellaceae, FamilyXIII, Ruminococcaceae, Senegalimassilia reduced In contrast, Erysipelotrichia, Erysipelotrichales, Pasteurellales, Erysipelotrichaceae, Pasteurellaceae, Methanobrevibacter, Roseburia, Terrisporobacter linked an elevated provides compelling evidence for offering novel insights into role pathogenesis
Language: Английский
Citations
2
European Journal of Preventive Cardiology, Journal Year: 2023, Volume and Issue: 30(12), P. 1274 - 1282
Published: May 17, 2023
Abstract Aims Studies have linked gut microbiome and heart failure (HF). However, their causal relationships potential mediating factors not been well defined. To investigate the between HF effect of blood lipids by using genetics. Methods results We performed a bidirectional mediation Mendelian randomization (MR) study summary statistics from genome-wide association studies microbial taxa (Dutch Microbiome Project, n = 7738), (UK Biobank, 115 078), meta-analysis (115 150 cases 1550 331 controls). applied inverse–variance weighted estimation method as primary method, with several other estimators complementary methods. The multivariable MR approach based on Bayesian model averaging (MR-BMA) was used to prioritize most likely lipids. Six are suggestively associated causally. significant taxon species Bacteroides dorei [odds ratio 1.059, 95% confidence interval (CI) 1.022–1.097, P-value 0.0017]. MR-BMA analysis showed that apolipoprotein B (ApoB) lipid for (the marginal inclusion probability 0.717, 0.005). ApoB mediated effects B. (proportion 10.1%, CI 0.2–21.6%, 0.031). Conclusion suggested relationship specific might mediate this determinant HF.
Language: Английский
Citations
38
Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: May 29, 2023
Objective The real causal relationship between human gut microbiota and T1D remains unclear difficult to establish. Herein, we adopted a two-sample bidirectional mendelian randomization (MR) study evaluate the causality T1D. Methods We leveraged publicly available genome-wide association (GWAS) summary data perform MR analysis. microbiota-related GWAS from 18,340 individuals international consortium MiBioGen were used. statistic for (n = 264,137) obtained latest release FinnGen as outcome of interest. selection instrumental variables conformed strictly series preset inclusion exclusion criteria. MR-Egger, weighted median, inverse variance (IVW), mode methods used assess association. Cochran’s Q test, MR-Egger intercept leave-one-out analysis conducted identify heterogeneity pleiotropy. Results At phylum level, only Bacteroidetes was indicated have on (OR 1.24, 95% CI 1.01-1.53, P 0.044) in IVW When it comes their subcategories, Bacteroidia class 1.28, 1.06-1.53, 0.009, FDR 0.085), Bacteroidales order Eubacterium eligens group genus 0.64, 0.50-0.81, 2.84×10 -4 , 0.031) observed with No pleiotropy detected. Conclusions present reports that phylum, class, causally increase risk, whereas genus, which belongs Firmicutes decreases risk. Nevertheless, future studies are warranted dissect underlying mechanisms specific bacterial taxa’s role pathophysiology
Language: Английский
Citations
34