Molecularly Imprinted Polymers: Antibody Mimics for Bioimaging and Therapy

Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(17), P. 9554 - 9582

Published: July 31, 2020

Molecularly imprinted polymers (MIPs) are tailor-made chemical receptors that recognize and bind target molecules with a high affinity selectivity. MIPs came into the spotlight in 1993 when they were dubbed "antibody mimics," ever since, have been widely studied for extraction or trapping of pollutants, immunoassays, design sensors. Owing to novel synthesis strategies resulting more biocompatible form soluble nanogels, these synthetic antibodies found favor biomedical domain since 2010, first time, shown capture eliminate toxin live mice. This review, covering years 2015-2020, will describe rationale behind antibody mimics, different methods employed preparation destined vitro vivo targeting bioimaging cancer biomarkers, an emerging fast-growing area MIP applications. synthesized visualizing glycans protein-based cell overexpressed certain diseases, which well-known biomarkers example tumors. When loaded drugs, could locally kill tumor cells, making them efficient therapeutic agents. We end review by reporting how themselves can act as therapeutics inhibiting growth. These works mark new opening use therapy even immunotherapy, materials future nanomedicine.

Language: Английский

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Multicomponent Plasmonic Nanoparticles: From Heterostructured Nanoparticles to Colloidal Composite Nanostructures

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(24), P. 12208 - 12278

Published: Dec. 3, 2019

Plasmonic nanostructures possessing unique and versatile optoelectronic properties have been vastly investigated over the past decade. However, full potential of plasmonic nanostructure has not yet fully exploited, particularly with single-component homogeneous structures monotonic properties, addition new components for making multicomponent nanoparticles may lead to new-yet-unexpected or improved properties. Here we define term "multi-component nanoparticles" as hybrid composed two more condensed nanoscale domains distinctive material compositions, shapes, sizes. We reviewed discussed designing principles synthetic strategies efficiently combine multiple form a functionality. In particular, it quite challenging precisely synthesize widely diverse structures, limiting realization heterostructures. To address this challenge, several approaches reported variety different nanoparticles, mainly based on heterogeneous nucleation, atomic replacements, adsorption supports, biomolecule-mediated assemblies. addition, synergistic features such combination pristine finely tuned plasmon resonance coupling, enhanced light-matter interactions, geometry-induced polarization, plasmon-induced energy charge transfer across heterointerface, were reported. review, comprehensively summarize latest advances state-of-art strategies, promising applications nanoparticles. These including heterostructured composite are prepared by direct synthesis physical force- assembly, which hold tremendous plasmon-mediated transfer, magnetic plasmonics, metamolecules, nanobiotechnology.

Language: Английский

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The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(4), P. 1253 - 1321

Published: Jan. 1, 2020

Bismuth-containing nanomaterials offer a new opportunity to move beyond current achievements in the fields of drug delivery, diagnosis, cancer therapy, biosensing, and tissue engineering. This review describes emerging applications perspective these nanoparticles.

Language: Английский

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Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window

Nano Letters, Journal Year: 2017, Volume and Issue: 17(8), P. 4964 - 4969

Published: June 27, 2017

Photoacoustic (PA) imaging holds great promise for preclinical research and clinical practice. However, most studies rely on the laser wavelength in first near-infrared (NIR) window (NIR-I, 650–950 nm), while few have been exploited second NIR (NIR-II, 1000–1700 mainly due to lack of NIR-II absorbing contrast agents. We herein report synthesis a broadband PA agent based semiconducting polymer nanoparticles (SPN-II) apply it window. SPN-II can absorb both NIR-I regions, providing feasibility directly compare at 750 nm with that 1064 nm. Because weaker background signals from biological tissues window, signal-to-noise ratio (SNR) resulted images be 1.4-times higher than when comparing depth 3 cm. The proof-of-concept application is demonstrated vivo brain vasculature living rats, which showed 1.5-times SNR as compared imaging. Our study not only introduces organic applicable windows but also reveals advantages over

Language: Английский

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Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications

Chemical Reviews, Journal Year: 2018, Volume and Issue: 119(3), P. 1666 - 1762

Published: Dec. 28, 2018

Organic/inorganic nanohybrids have attracted widespread interests due to their favorable properties and promising applications in biomedical areas. Great efforts been made design fabricate versatile nanohybrids. Among different organic components, diverse polymers offer unique avenues for multifunctional systems with collective properties. This review focuses on the design, properties, of organic/inorganic fabricated from inorganic nanoparticles polymers. We begin a brief introduction variety strategies fabrication functional Then functions are discussed, including parts, synergistic morphology-dependent self-assembly After that, current situations applied imaging, therapy, imaging-guided therapy demonstrated. Finally, we discuss prospect highlight challenges opportunities future investigations.

Language: Английский

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An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(36)

Published: July 21, 2020

Abstract Aiming to achieve versatile phototheranostics with the integrated functionalities of multiple diagnostic imaging and synergistic therapy, optimum use dissipated energy through both radiative nonradiative pathways is definitely appealing, yet a significantly challenging task. To best knowledge, there have been no previous reports on single molecular species effective at affording all phototheranostic modalities including fluorescence (FLI), photoacoustic (PAI), photothermal (PTI), photodynamic therapy (PDT), (PTT). Herein, simple highly powerful one‐for‐all based aggregation‐induced emission (AIE)‐active fluorophores tactfully designed constructed. Thanks its strong electron donor–acceptor interaction finely modulated intramolecular motion, AIE fluorophore‐based nanoparticles simultaneously exhibit bright near‐infrared II (NIR‐II) emission, efficient reactive oxygen generation, high conversion efficiency upon NIR irradiation, indicating actualization balance between dissipations. Furthermore, unprecedented performance NIR‐II FLI‐PAI‐PTI trimodal‐imaging‐guided PDT–PTT demonstrated by precise tumor diagnosis complete elimination outcomes. This study thus brings new insight into development superior for practical cancer theranostics.

Language: Английский

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Fluorine-free preparation of titanium carbide MXene quantum dots with high near-infrared photothermal performances for cancer therapy

Nanoscale, Journal Year: 2017, Volume and Issue: 9(45), P. 17859 - 17864

Published: Jan. 1, 2017

Titanium carbide MXene quantum dots (QDs) were synthesized using an effective fluorine-free method as a biocompatible and highly efficient nanoagent for photothermal therapy (PTT) applications. In contrast to the traditional, hazardous time-consuming process of HF pretreatment, our is safe simple. More importantly, abundant Al oxoanions found be modified on QD surface by method, which endowed QDs with strong broad absorption in NIR region. As result, as-prepared exhibited extinction coefficient large 52.8 Lg-1 cm-1 at 808 nm conversion efficiency high 52.2%. Both values are among best reported so far. The achieved simultaneous photoacoustic (PA) imaging remarkable PTT effect tumors. Moreover, showed great biocompatibility without causing noticeable toxicity vitro vivo, indicating their potential clinical

Language: Английский

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Bridging Bio–Nano Science and Cancer Nanomedicine

ACS Nano, Journal Year: 2017, Volume and Issue: 11(10), P. 9594 - 9613

Published: Sept. 19, 2017

The interface of bio–nano science and cancer medicine is an area experiencing much progress but also beset with controversy. Core concepts the field—e.g., enhanced permeability retention (EPR) effect, tumor targeting accumulation, even purpose "nano" in medicine—are hotly debated. In parallel, considerable advances neighboring fields are occurring rapidly, including recent "immuno-oncology" fundamental impact it having on our understanding clinical treatment group diseases collectively known as cancer. Herein, we (i) revisit how commonly treated clinic this relates to nanomedicine; (ii) examine ongoing debate relevance EPR effect targeting; (iii) highlight ways improve next-generation nanomedicines; (iv) discuss emerging concept working (and not against) biology. While discussing these controversies, challenges, concepts, opportunities, explore new directions for field nanomedicine.

Language: Английский

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Cell Membrane Coated Semiconducting Polymer Nanoparticles for Enhanced Multimodal Cancer Phototheranostics

ACS Nano, Journal Year: 2018, Volume and Issue: 12(8), P. 8520 - 8530

Published: Aug. 2, 2018

Phototheranostic nanoagents are promising for early diagnosis and precision therapy of cancer. However, their imaging ability therapeutic efficacy often limited due to the presence delivery barriers in tumor microenvironment. Herein, we report development organic multimodal phototheranostic that can biomimetically target cancer-associated fibroblasts microenvironment enhanced imaging-guided cancer therapy. Such biomimetic nanocamouflages comprise a near-infrared (NIR) absorbing semiconducting polymer nanoparticle (SPN) coated with cell membranes activated fibroblasts. The homologous targeting mechanism allows fibroblast membrane SPN (AF-SPN) specifically fibroblasts, leading accumulation relative uncoated counterparts after systemic administration living mice. As such, AF-SPN not only provides stronger NIR fluorescence photoacoustic signals detect tumors but also generates cytotoxic heat singlet oxygen exert combinational photothermal photodynamic therapy, ultimately an antitumor higher than counterparts. This study introduces system targets component theranostics.

Language: Английский

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Activatable NIR Fluorescence/MRI Bimodal Probes for in Vivo Imaging by Enzyme-Mediated Fluorogenic Reaction and Self-Assembly

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(26), P. 10331 - 10341

Published: June 7, 2019

Stimuli-responsive in situ self-assembly of small molecules to form nanostructures living subjects has produced promising tools for molecular imaging and tissue engineering. However, controlling the process simultaneously activate multimodality signals a small-molecule probe is challenging. In this paper, we rationally integrate fluorogenic reaction into enzyme-responsive design small-molecule-based activatable near-infrared (NIR) fluorescence magnetic resonance (MR) bimodal probes imaging. Using alkaline phosphatase (ALP) as model target, demonstrate that (P-CyFF-Gd) can be activated by endogenous ALP overexpressed on cell membranes, producing membrane-localized assembled nanoparticles (NPs) directly visualized cryo-SEM. Simultaneous enhancements NIR (>70-fold at 710 nm) r1 relaxivity (∼2.3-fold) enable real-time, high-sensitivity, high-spatial-resolution localization activity live tumor cells mice. P-CyFF-Gd also delineate orthotopic liver foci, facilitating efficient image-guided surgical resection tissues intraoperative This strategy combines via MRI promote imaging, which could applicable other vivo enzyme locations real time.

Language: Английский

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