Antibody–Drug Conjugates for Cancer Therapy

Molecules, Journal Year: 2020, Volume and Issue: 25(20), P. 4764 - 4764

Published: Oct. 16, 2020

Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for delivery potent cytotoxic payload. ADCs provide unique opportunity deliver tumor while minimizing toxicity normal tissue, achieving wider therapeutic windows and enhanced pharmacokinetic/pharmacodynamic properties. To date, nine have been approved by FDA more than 80 under clinical development worldwide. In this paper, we an overview biology chemistry each component ADC design. We briefly discuss experience with various pathways involved in resistance. conclude perspectives about future next generations ADCs, including role molecular imaging drug development.

Language: Английский

---

Colyliform Crystalline 2D Covalent Organic Frameworks (COFs) with Quasi‐3D Topologies for Rapid I₂ Adsorption

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(50), P. 22697 - 22705

Published: Sept. 2, 2020

Abstract Constructing three‐dimensional (3D) structural characteristics on two‐dimensional (2D) covalent organic frameworks (COFs) is a good approach to effectively improve the permeability and mass transfer rate of materials realize rapid adsorption for guest molecules, while avoiding high cost monomer scarcity in preparing 3D COFs. Herein, we report first time series colyliform crystalline 2D COFs with quasi‐three‐dimensional (Q‐3D) topologies, consisting unique “stereoscopic” triangular pores, large interlayer spacings flexible constitutional units which makes pores elastic self‐adaptable transmission. The as‐prepared QTD‐COFs have faster (2.51 g h −1 ) iodine than traditional COFs, an unprecedented maximum capacity 6.29 . excellent performance, as well prominent irradiation stability allow be applied removal radioactive iodine.

Language: Английский

---

Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities

Trends in Immunology, Journal Year: 2019, Volume and Issue: 40(6), P. 511 - 523

Published: April 30, 2019

Language: Английский

---

Large-vessel vasculitis

Nature Reviews Disease Primers, Journal Year: 2022, Volume and Issue: 7(1)

Published: Jan. 6, 2022

Language: Английский

---

Radiochemistry for positron emission tomography

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: June 5, 2023

Abstract Positron emission tomography (PET) constitutes a functional imaging technique that is harnessed to probe biological processes in vivo. PET has been used diagnose and monitor the progression of diseases, as well facilitate drug development efforts at both preclinical clinical stages. The wide applications rapid have ultimately led an increasing demand for new methods radiochemistry, with aim expand scope synthons amenable radiolabeling. In this work, we provide overview commonly chemical transformations syntheses tracers all aspects thereby highlighting recent breakthrough discoveries contemporary challenges field. We discuss use biologicals highlight general examples successful molecular – particular focus on translational scalable radiochemistry concepts entered use.

Language: Английский

---

Biomarkers for immunotherapy of hepatocellular carcinoma

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(11), P. 780 - 798

Published: Sept. 19, 2023

Language: Английский

---

Molecular and functional imaging in cancer-targeted therapy: current applications and future directions

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Feb. 27, 2023

Targeted anticancer drugs block cancer cell growth by interfering with specific signaling pathways vital to carcinogenesis and tumor rather than harming all rapidly dividing cells as in cytotoxic chemotherapy. The Response Evaluation Criteria Solid Tumor (RECIST) system has been used assess response therapy via changes the size of target lesions measured calipers, conventional anatomically based imaging modalities such computed tomography (CT), magnetic resonance (MRI), other methods. However, RECIST is sometimes inaccurate assessing efficacy targeted because poor correlation between treatment-induced necrosis or shrinkage. This approach might also result delayed identification when does confer a reduction size. Innovative molecular techniques have gained importance dawning era they can visualize, characterize, quantify biological processes at cellular, subcellular, even level anatomical level. review summarizes different pathways, various techniques, developed probes. Moreover, application for evaluating treatment related clinical outcome systematically outlined. In future, more attention should be paid promoting translation sensitivity biocompatible particular, multimodal technologies incorporating advanced artificial intelligence comprehensively accurately cancer-targeted therapy, addition RECIST-based

Language: Английский

---

The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(12), P. 7782 - 7853

Published: May 15, 2023

The high selectivity and affinity of antibodies toward their antigens have made them a highly valuable tool in disease therapy, diagnosis, basic research. A plethora chemical genetic approaches been devised to make accessible more "undruggable" targets equipped with new functions illustrating or regulating biological processes precisely. In this Review, addition introducing how naked various antibody conjugates (such as antibody-drug conjugates, antibody-oligonucleotide antibody-enzyme etc.) work therapeutic applications, special attention has paid chemistry tools helped optimize the outcome (i.e., enhanced efficacy reduced side effects) facilitate multifunctionalization antibodies, focus on emerging fields such targeted protein degradation, real-time live-cell imaging, catalytic labeling decaging spatiotemporal control well engagement inside cells. With advances modern biotechnology, well-designed derivatives via size miniaturization together efficient delivery systems emerged, which gradually improved our understanding important paved way pursue novel for potential treatments diseases.

Language: Английский

---

Nanoprobe-based molecular imaging for tumor stratification

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(18), P. 6447 - 6496

Published: Jan. 1, 2023

This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.

Language: Английский

---

Ultralight crystalline hybrid composite material for highly efficient sequestration of radioiodine

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 10, 2024

Abstract Considering the importance of sustainable nuclear energy, effective management radioactive waste, such as sequestration radioiodine has inflicted a significant research attention in recent years. Despite fact that materials have been reported for adsorption iodine, development adsorbent with significantly improved segregation properties widespread practical applications still remain exceedingly difficult due to lack proper design strategies. Herein, utilizing unique hybridization synthetic strategy, composite crystalline aerogel material fabricated by covalent stepping an amino-functionalized stable cationic discrete metal-organic polyhedra dual-pore containing imine-functionalized organic framework. The ultralight hybrid exhibits large surface area hierarchical macro-micro porosity and multifunctional binding sites, which collectively interact iodine. developed nano-adsorbent demonstrate ultrahigh vapor aqueous-phase iodine capacities 9.98 g.g −1 4.74 , respectively, static conditions fast kinetics, high retention efficiency, reusability recovery.

Language: Английский

---