Journal of Neuro-Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12931 - 12931
Published: Aug. 18, 2023
Peptide-based strategies have received an enormous amount of attention because their specificity and applicability. Their tumor-targeting ability are applied to diagnosis treatment for cancer patients. In this review, we will summarize recent advancements future perspectives on peptide-based treatment. The literature search was conducted identify relevant articles It performed using PubMed in English until June 2023. Information clinical trials also obtained from ClinicalTrial.gov. Given that several advantages such as targeted delivery the diseased area, personalized designs, relatively small sizes, simple production process, bioactive peptides having anti-cancer activities (anti-cancer or ACPs) been tested pre-clinical settings trials. capability tumor targeting is essentially useful peptide-drug conjugates (PDCs), diagnosis, image-guided surgery. Immunomodulation with peptide vaccines has extensively Despite advantages, FDA-approved agents solid still limited. This review provide a detailed overview current approaches, design strategies, routes administration, new technological advancements. We highlight success limitations therapies
Language: Английский
Citations
55
Egyptian Liver Journal, Journal Year: 2024, Volume and Issue: 14(1)
Published: Jan. 2, 2024
Abstract Background Hepatocellular carcinoma (HCC) is a common type of liver cancer, with high mortality rate. cancer that can be effectively managed through early detection and accurate diagnosis, followed by personalized treatment plan may include surgical resection, transplantation, minimally-invasive techniques, immunotherapy, or targeted therapy depending on the stage severity cancer. Main body abstract This paper discusses recent advances in detection, management, prevention HCC. The use newer imaging such as Magnetic resonance (MRI) contrast-enhanced ultrasound, along image segmentation technology deep learning models, have greatly enhanced accuracy HCC diagnosis. Minimally-invasive thermal ablation radiofrequency ablation, allowed for more precise destruction tumors, while Nanoparticles, immunotherapy shown promise management advanced Artificial intelligence (AI) machine has revolutionized research, aiding identification high-risk patients predicting outcomes. Lifestyle modifications, weight alcohol avoidance, hepatitis B vaccinations, play critical role preventing development. Short conclusion Recent improving patient therapy, AI research lifestyle modifications prevention. However, further required to fully understand potential benefits nanoparticles, traditional Chinese medicine herbal medicines treatment. Graphical
Language: Английский
Citations
35
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 9, 2025
Abstract Anti‐tumor theranostic radionuclide nanosystems have gained significant attention as an emerging therapeutic strategy. This review systematically elucidates the concept and recent advances of anti‐tumor nanotheranostic systems with radionuclides, a focus on design nanocarriers, precise selection their advantages limitations in clinical translation. also explores integration imaging various treatment modalities, including photodynamic therapy, photothermal sonodynamic immunotherapy. Furthermore, combination therapy fluorescence magnetic resonance technologies, which broadens application nanotheranostics, is discussed. Finally, outlooks future development nanotheranostics radionuclides proposes key research focus.
Language: Английский
Citations
3
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 2, 2025
Chemiluminescence (CL) is a self-illuminating phenomenon fueled by chemical energy instead of extra excited light, which features superiority in sensitivity, signal-to-background ratios, and imaging depth. Strategies to synthesize CL emission unimolecular skeleton the second near-infrared window (NIR-II) probe with direct duplex NIR-II [CL/fluorescence (FL)] are lacking. Here, we employ modular synthesis routes construct series directly activated probes maximum wavelength up 1060 nm, use them for real-time continuous detection superoxide anion generated acetaminophen induced liver injury female mice model under both FL channels. Thus, this study establishes activatable skeleton, validating scalability CL/FL platform bioactive molecule disease diagnosis. chemiluminescence authors NIRII
Language: Английский
Citations
2
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 12, 2024
Abstract The lanthanide complex, characterized by narrow emission bands, large Stokes shifts, long luminescence lifetime, robust resistance to photobleaching, and magnetic properties, affords significant promise for molecular imaging biosensing applications. While most complexes emitting visible light are extensively studied cellular‐level detection bioimaging, near‐infrared‐emitted (700–1700 nm) compounds exhibit more favorable properties bioimaging biosensing, ascribed from deeper penetration reduced bleaching effects. Besides, the complex with higher resonance signals can enhance image resolution sensitivity, offering precise analysis. However, widespread use of high‐efficiency is currently impeded lack design approaches improving sensitization chromophores extended excitation wavelengths. In this review, some fundamental theories strategies summarized imaging, lifetime‐engineered dual‐modal now highlight a selection review addresses existing gap in literature proposing feasible fluorescent properties. Concurrently, future challenges opportunities field probes discussed.
Language: Английский
Citations
12
Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 827 - 827
Published: April 9, 2024
Tumor angiogenesis, the formation of new blood vessels within tumor microenvironment, is considered a hallmark cancer progression and represents crucial target for therapeutic intervention. The microenvironment characterized by complex interplay between proangiogenic antiangiogenic factors, regulating vascularization necessary growth metastasis. study angiogenesis involves spectrum techniques, spanning from biomarker assessment to advanced imaging modalities. This comprehensive review aims provide insights into molecular intricacies, regulatory dynamics, clinical implications angiogenesis. By delving these aspects, we gain deeper understanding processes driving in tumors, paving way development novel effective therapies fight against cancer.
Language: Английский
Citations
10
Journal of Radioanalytical and Nuclear Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Language: Английский
Citations
2
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 5, 2025
Photoacoustic brain imaging (PABI) has emerged as a promising biomedical modality, combining high contrast of optical with deep tissue penetration ultrasound imaging. This review explores the application photoacoustic in tumor imaging, highlighting synergy between nanomaterials and state art techniques to achieve high-resolution deeper tissues. PABI leverages effect, where absorbed light energy causes thermoelastic expansion, generating waves that are detected converted into images. technique enables precise diagnosis, therapy monitoring, enhanced clinical screening, specifically management complex diseases such breast cancer, lymphatic disorder, neurological conditions. Despite integration agents radiation, providing comprehensive overview current methodologies, major obstacles treatment, future directions for improving diagnostic therapeutic outcomes. The underscores significance robust research tool medical method, potential revolutionize disease diagnosis treatment.
Language: Английский
Citations
2
Molecular Therapy — Nucleic Acids, Journal Year: 2025, Volume and Issue: 36(1), P. 102483 - 102483
Published: Feb. 11, 2025
Aptamers are single-stranded oligonucleotides with specific spatial structures. They have been widely used in preclinical studies because of their high affinity and specificity for various biological targets. AS1411, an aptamer targeting the nucleolin overexpressed on cancer cell membrane, is one most promising extensively studied aptamers. However, extremely low bioavailability due to rapid renal excretion remains a great obstacle aptamers' clinical translation. Human serum albumin (HSA), long blood circulation excellent biocompatibility, has attractive vehicle extending drugs' half-life clinic. This work investigated effect albumin-conjugated strategy improving tumor vivo first time by taking AS1411 as example. HSA-AS1411 was synthesized via maleimide-sulfhydryl reaction. The stability maintained target were demonstrated vitro. pharmacokinetic analysis SPECT imaging revealed that had over 14 times longer superior uptake than those AS1411. immunofluorescence staining tissues further indicated improved retention result prolonged circulation. Therefore, HSA-conjugated prospect applications.
Language: Английский
Citations
1
Nature Biomedical Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Language: Английский
Citations
1