Tissue Engineering Part B Reviews,
Journal Year:
2020,
Volume and Issue:
27(5), P. 486 - 513
Published: Oct. 29, 2020
Methylcellulose
(MC)
is
an
attractive
material
used
to
produce
thermo-responsive
hydrogels.
They
undergo
sol-gel
transition
when
a
critical
temperature
reached,
thus
modifying
their
properties
(e.g.,
physicochemical
and
mechanical)
in
response
changes.
This
behavior
particularly
the
body
acts
as
trigger
modulate
of
MC
In
this
regard,
exciting
advances
have
been
achieved
field
cell
drug
delivery,
tissue
engineering,
regenerative
medicine,
making
very
versatile
biomaterial.
review
aims
present
hydrogels,
examining
preparation,
physical
properties,
tunability
thermal
response,
lastly
moving
comprehensive
depiction
both
conventional
innovative
applications
for
regeneration
purposes.
particular,
three
main
families
are
introduced:
(1)
situ
gelling
systems,
which
upon
delivery
into
target
site
or
organ),
assisting
latter
presence
absence
loading
components
cells,
biomolecules,
inorganic
materials);
(2)
three-dimensional
(3D)
(bio)printing,
where
induced
by
heating
MC-based
(bio)inks
after
printing,
obtaining
3D
tissue-engineered
substitutes
with
defined
geometries
high
shape
fidelity;
(3)
smart
culture
surfaces,
hydrophilic/hydrophobic
exploited
reach
selective
attachment/detachment
offering
possibility
obtain
sheets
bodies
reconstruction
without
need
any
proteolytic
enzyme.
The
limitations
hydrogels
will
be
then
examined,
together
current
solutions
overcome
them.
Moreover,
overview
future
directions
given,
particular
focus
on
design
multiresponsive
systems
capable
respond
multiple
stimuli
chemical
biological
stimuli),
toward
development
more
patient-specific
treatments.
Finally,
patents
clinical
trials
describing
use
retracing
abovementioned
application.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
123(2), P. 834 - 873
Published: Aug. 5, 2022
Biomaterials
with
the
ability
to
self-heal
and
recover
their
structural
integrity
offer
many
advantages
for
applications
in
biomedicine.
The
past
decade
has
witnessed
rapid
emergence
of
a
new
class
self-healing
biomaterials
commonly
termed
injectable,
or
printable
context
3D
printing.
These
injectable
biomaterials,
mostly
hydrogels
other
soft
condensed
matter
based
on
reversible
chemistry,
are
able
temporarily
fluidize
under
shear
stress
subsequently
original
mechanical
properties.
Self-healing
distinct
compared
traditional
biomaterials.
Most
notably,
they
can
be
administered
locally
targeted
minimally
invasive
manner
through
narrow
syringe
without
need
surgery.
Their
moldability
allows
patient-specific
intervention
shows
great
prospects
personalized
medicine.
Injected
facilitate
tissue
regeneration
multiple
ways
owing
viscoelastic
diffusive
nature,
ranging
from
simple
support,
spatiotemporally
controlled
delivery
cells
therapeutics,
local
recruitment
modulation
host
promote
regeneration.
Consequently,
have
been
at
forefront
cutting-edge
strategies.
This
study
provides
critical
review
current
state
As
key
challenges
toward
further
maturation
this
exciting
research
field,
we
identify
(i)
trade-off
between
injectability
vs
physical
stability,
(ii)
lack
consensus
rheological
characterization
quantitative
benchmarks
hydrogels,
particularly
regarding
capillary
flow
syringes,
(iii)
practical
limitations
translation
therapeutically
effective
formulations
specific
tissues.
Hence,
here
chemical
design
strategies
provide
guide
analysis,
showcase
applicability
various
tissues
printing
complex
organoids.
Gels,
Journal Year:
2022,
Volume and Issue:
8(3), P. 179 - 179
Published: March 14, 2022
Three-dimensional
(3D)
printing
is
well
acknowledged
to
constitute
an
important
technology
in
tissue
engineering,
largely
due
the
increasing
global
demand
for
organ
replacement
and
regeneration.
In
3D
bioprinting,
which
a
step
ahead
of
biomaterial
printing,
ink
employed
impregnated
with
cells,
without
compromising
printability.
This
allows
immediate
scaffold
cellularization
generation
complex
structures.
The
use
cell-laden
inks
or
bio-inks
provides
opportunity
enhanced
cell
differentiation
fabrication
Recognizing
importance
such
bio-inks,
current
study
comprehensively
explores
state
art
utilization
based
on
natural
polymers
(biopolymers),
as
cellulose,
agarose,
alginate,
decellularized
matrix,
bioprinting.
Discussions
regarding
progress
techniques
approaches
bioprinting
polymers,
limitations
prospects
concerning
future
trends
human-scale
are
also
presented.
iScience,
Journal Year:
2023,
Volume and Issue:
26(2), P. 106039 - 106039
Published: Jan. 25, 2023
Three-dimensional
(3D)
bioprinting
has
emerged
as
a
class
of
promising
techniques
in
biomedical
research
for
wide
range
related
applications.
Specifically,
stereolithography
apparatus
(SLA)
and
digital
light
processing
(DLP)-based
vat-polymerization
are
highly
effective
methods
bioprinting,
which
can
be
used
to
produce
high-resolution
architecturally
sophisticated
structures.
Our
review
aims
provide
an
overview
SLA-
DLP-based
3D
strategies,
starting
from
factors
that
affect
these
processes.
In
addition,
we
summarize
the
advances
bioinks
SLA
DLP,
including
naturally
derived
synthetic
bioinks.
Finally,
applications
both
discussed,
primarily
centered
on
regenerative
medicine
tissue
modeling
engineering.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: May 14, 2021
Abstract
Rapid
development
of
vaccines
and
therapeutics
is
necessary
to
tackle
the
emergence
new
pathogens
infectious
diseases.
To
speed
up
drug
discovery
process,
conventional
pipeline
can
be
retooled
by
introducing
advanced
in
vitro
models
as
alternatives
disease
employing
technology
for
production
medicine
cell/drug
delivery
systems.
In
this
regard,
layer-by-layer
construction
with
a
3D
bioprinting
system
or
other
technologies
provides
beneficial
method
developing
highly
biomimetic
reliable
research.
addition,
high
flexibility
versatility
offer
advantages
effective
vaccines,
therapeutics,
relevant
Herein,
we
discuss
potential
control
We
also
suggest
that
research
could
significant
platform
rapid
automated
tissue/organ
medicines
near
future.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(23)
Published: April 30, 2021
Light
guiding
and
manipulation
in
photonics
have
become
ubiquitous
events
ranging
from
everyday
communications
to
complex
robotics
nanomedicine.
The
speed
sensitivity
of
light-matter
interactions
offer
unprecedented
advantages
biomedical
optics,
data
transmission,
photomedicine,
detection
multi-scale
phenomena.
Recently,
hydrogels
emerged
as
a
promising
candidate
for
interfacing
bioengineering
by
combining
their
light-guiding
properties
with
live
tissue
compatibility
optical,
chemical,
physiological,
mechanical
dimensions.
Herein,
the
latest
progress
over
hydrogel
its
applications
guidance
light
is
reviewed.
Physics
through
living
tissues,
existing
technical
challenges
translating
these
tools
into
settings
are
discussed.
A
comprehensive
thorough
overview
materials,
fabrication
protocols,
design
architectures
used
provided.
Finally,
recent
examples
applying
structures
such
optical
fibers,
photonic
constructs,
use
light-driven
robots,
photomedicine
tools,
organ-on-a-chip
models
described.
By
providing
critical
selective
evaluation
field's
status,
this
work
sets
foundation
next
generation
research.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: June 9, 2022
Digital
light
processing
bioprinting
favors
biofabrication
of
tissues
with
improved
structural
complexity.
However,
soft-tissue
fabrication
this
method
remains
a
challenge
to
balance
the
physical
performances
bioinks
for
high-fidelity
and
suitable
microenvironments
encapsulated
cells
thrive.
Here,
we
propose
molecular
cleavage
approach,
where
hyaluronic
acid
methacrylate
(HAMA)
is
mixed
gelatin
methacryloyl
achieve
high-performance
bioprinting,
followed
by
selectively
enzymatic
digestion
HAMA,
resulting
in
tissue-matching
mechanical
properties
without
losing
complexity
fidelity.
Our
allows
cellular
morphological
functional
improvements
across
multiple
bioprinted
tissue
types
featuring
wide
range
stiffness,
from
muscles
brain,
softest
organ
human
body.
This
platform
endows
us
biofabricate
mechanically
precisely
tunable
constructs
meet
biological
function
requirements
target
tissues,
potentially
paving
way
broad
applications
model
engineering.
Physiological Reviews,
Journal Year:
2022,
Volume and Issue:
102(3), P. 1495 - 1552
Published: March 28, 2022
Salivary
glands
produce
and
secrete
saliva,
which
is
essential
for
maintaining
oral
health
overall
health.
Understanding
both
the
unique
structure
physiological
function
of
salivary
glands,
as
well
how
they
are
affected
by
disease
injury,
will
direct
development
therapy
to
repair
regenerate
them.
Significant
recent
advances,
particularly
in
OMICS
field,
increase
our
understanding
develop
at
cellular,
molecular,
genetic
levels:
signaling
pathways
involved,
dynamics
progenitor
cell
lineages
development,
homeostasis,
regeneration,
role
extracellular
matrix
microenvironment.
These
provide
a
template
gene
therapies
bioengineering
approaches
or
function.
