Journal of Hazardous Materials Advances,
Journal Year:
2023,
Volume and Issue:
11, P. 100355 - 100355
Published: Aug. 1, 2023
Regulations
for
contaminants
are
primarily
based
on
isolated
exposures
to
an
individual
toxicant.
This
practice
does
not
account
interactions
that
may
happen
between
toxicants.
The
assessment
of
chemical
mixtures
ought
be
routinely
studied
better
understand
the
risks
human
health,
yet
no
standard
protocol
exists.
study
provides
a
framework
focusing
complex
toxicants
and
how
can
affect
potential
regulatory
shift.
work
evaluates
binary
environmental
contaminants,
lead(II)
acetate,
copper(II)
nitrate,
glyphosate,
against
neuronal
brain
cell
model
(SH-SY5Y)
by
comparing
concentration
addition
(CA)
experimental
cytotoxicity
values.
Binary
mixture
effects
were
identified
interpreted
using
interaction
index
isobologram.
Isobolograms
developed
visualize
comparative
data.
Against
model,
EC50
values
composed
copper-lead
copper-glyphosate
showed
antagonistic
responses
with
indices
greater
than
one.
lead-glyphosate
produced
additive
within
95%
confidence
interval
These
results,
along
mechanism
elucidations,
illustrate
complexity
toxicology
need
further
studies
emphasizing
comparisons
prediction
modeling
results.
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(12), P. 4852 - 4862
Published: March 16, 2023
Inappropriate
application
of
pesticides
not
only
causes
sub-lethal
effects
on
ecosystem
service
providers
but
also
reduces
crop
yield
and
quality.
As
a
xenobiotic
signal
molecule,
may
interact
with
transduction
receptors
in
crops,
resulting
oxidative
damage
even
metabolic
perturbations.
We
discovered
that
three
neonicotinoid
insecticides
(NIs),
namely,
imidacloprid,
thiamethoxam,
clothianidin,
at
0.06-0.12
kg
ai/ha
significantly
inhibited
the
auxin
pathway
rice
leaves,
thereby
reducing
intracellular
(IAA)
content.
Molecular
simulation
further
confirmed
NIs
occupied
binding
site
where
transporter-like
proteins
1
(LAX11)
2
(LAX12),
which
Thr253
Asn66
LAX11,
as
well
Thr244
Asn57
LAX12,
were
bound
to
nitroguanidine
via
H-bonds.
Meanwhile,
LAX11
LAX12
interacted
aromatic
Moreover,
phenylpropanoid
biosynthesis
was
disturbed
because
pathway.
Notably,
peroxidase-coding
genes
downregulated
maximum
value
greater
than
10-fold,
decreased
antioxidant
metabolites
flavone
(37.82%)
lignin
content
(20.15%).
Ultimately,
biomass
reduced
by
up
25.41%
due
decline
IAA
capacity.
This
study
deeply
explored
molecular
mechanism
perturbations
crops
stressed
pesticides,
thus
providing
scientific
basis
for
pesticide
environmental
risk
assessment
agricultural
product
safety.
Toxics,
Journal Year:
2023,
Volume and Issue:
11(7), P. 598 - 598
Published: July 8, 2023
Recently,
neonicotinoids
have
become
the
fastest-growing
class
of
insecticides
in
conventional
crop
protection,
with
extensive
usage
against
a
wide
range
sucking
and
chewing
pests.
Neonicotinoids
are
widely
used
due
to
their
high
toxicity
invertebrates,
simplicity,
flexibility
which
they
may
be
applied,
lengthy
persistence,
systemic
nature
ensures
that
spread
all
sections
target
crop.
However,
these
properties
raise
risk
environmental
contaminations
potential
non-target
organisms.
Acetamiprid
is
new
generation
insecticide,
safer
alternative
for
controlling
insect
pests
because
its
low
honeybees.
intended
nicotinic
acetylcholine
receptors
insects,
but
widespread
has
resulted
negative
impacts
on
animals
such
as
mammals.
This
review
summarizes
vivo
vitro
animal
studies
investigated
specific
neonicotinoids.
With
summarized
data,
it
can
presumed
certain
concentrations
reproductive
system
cause
oxidative
stress
testis;
spermatogenesis
disruption;
spermatozoa
degradation;
interruptions
endocrine
function
Sertoli
Leydig
cell
function.
In
female
system,
acetamiprid
evokes
pathomorphological
alterations
follicles,
along
metabolic
changes
ovaries.
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(13), P. 5358 - 5367
Published: March 22, 2023
Little
is
known
about
exposure
of
infants
to
neonicotinoid
insecticides
(NEOs).
In
this
study,
concentrations
six
parent
NEOs
(p-NEOs)
and
N-desmethyl-acetamiprid
(N-dm-ACE)
were
measured
in
urine
whole
blood
samples
from
infants,
addition
breast
milk,
infant
formula,
tap
water
collected
South
China.
The
p-NEO
with
the
highest
median
concentration
(0.25
ng/mL)
(1.30)
was
dinotefuran
(DIN),
while
imidacloprid
(IMI)
abundant
milk
(median:
0.27
ng/mL),
formula
(0.22),
(0.028).
older
(181-360
days)
might
face
higher
NEO
N-dm-ACE
than
younger
(0-180
days).
Blood
contained
a
significantly
(p
<
0.01)
∑6p-NEOs
(2.03
that
(0.41),
similar
acetamiprid
(ACE),
IMI,
thiacloprid
(THD),
DIN,
N-dm-ACE,
suggesting
readily
partition
into
blood.
Furthermore,
breast-fed
tend
have
levels
formula-fed
infants.
Infant
prepared
augmented
daily
intake
∑NEOs.
external
sources
contributed
80%
total
dose
IMI
clothianidin
(CLO)
exposure,
other
unknown
ACE,
THD,
DIN
To
best
our
knowledge,
first
study
assess
infantile
through
internal
assessment.
