Cited by Investigation of the mechanism of silica-induced pulmonary fibrosis: The role of lung microbiota dysbiosis and the LPS/TLR4 signaling pathway

The Effects and Pathogenesis of PM2.5 and Its Components on Chronic Obstructive Pulmonary Disease DOI

Qi Wang, Sha Liu

International Journal of COPD, Journal Year: 2023, Volume and Issue: Volume 18, P. 493 - 506

Published: April 1, 2023

Chronic obstructive pulmonary disease (COPD), a heterogeneous disease, is the leading cause of death worldwide. In recent years, air pollution, especially particulate matter (PM), has been widely studied as contributing factor to COPD. As an essential component PM, PM2.5 associated with COPD prevalence, morbidity, and acute exacerbations. However, specific pathogenic mechanisms were still unclear deserve further research. The diversity complexity components make it challenging get its accurate effects for It determined that most toxic are metals, polycyclic aromatic hydrocarbons (PAHs), carbonaceous particles (CPs), other organic compounds. PM2.5-induced cytokine release oxidative stress main reported Nonnegligibly, microorganism in PM 2.5 may directly mononuclear inflammation or break balance development exacerbation This review focuses on pathophysiology consequences

Language: Английский

Citations

Overview of PM2.5 and health outcomes: Focusing on components, sources, and pollutant mixture co-exposure DOI

Nan Nan,

Zhipeng Yan,

Yaru Zhang

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 323, P. 138181 - 138181

Published: Feb. 20, 2023

Language: Английский

Citations

Individual and joint associations of long-term exposure to air pollutants and cardiopulmonary mortality: a 22-year cohort study in Northern China DOI

Wenzhong Huang, Yang Zhou, Xi Chen

et al.

The Lancet Regional Health - Western Pacific, Journal Year: 2023, Volume and Issue: 36, P. 100776 - 100776

Published: May 4, 2023

Evidence on the associations between long-term exposure to multiple air pollutants and cardiopulmonary mortality is limited, especially for developing regions with higher pollutant levels. We aimed characterise individual joint (multi-pollutant) of mortality, identify that primarily contributes risk.

Language: Английский

Citations

Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations DOI

Beatriz Chamorro,

Karelle De Luca,

Gokul Swaminathan

et al.

Clinical Microbiology Reviews, Journal Year: 2023, Volume and Issue: 36(3)

Published: June 12, 2023

and

Language: Английский

Citations

Airborne Nanoplastics Exposure Inducing Irreversible Glucose Increase and Complete Hepatic Insulin Resistance DOI

Ziye Yang,

Huajiang Dong,

Yifei Gao

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 6, 2024

As an emerging type of pollutant, microplastics have become a global environmental problem. Approximately, fifth the burden 2 diabetes can be attributed to air particulate pollution. However, scientific knowledge remains limited about effects airborne nanoplastics (NPs) exposure on metabolic diseases. In this experiment, whole-body system was used simulate real atmospheric environment, and three concentrations combined with actual concentration were selected explore NPs Based histological analyses, studies, gene expression, metabolites, molecular signaling mice exposed observed show phenotype systemic inflammation complete insulin resistance featuring excessive drinking eating, weight loss, elevated blood glucose, decreased triglyceride levels. After exposure, intolerant glucose tolerant insulin. addition, could result in long-term irreversible hyperglycemia. Together, research findings provide strong basis for understanding hazards nanopollution disorders.

Language: Английский

Citations

Fine particulate matter manipulates immune response to exacerbate microbial pathogenesis in the respiratory tract DOI

Jason Ma,

Ya‐Fang Chiu,

Chih-Chen Kao

et al.

European Respiratory Review, Journal Year: 2024, Volume and Issue: 33(173), P. 230259 - 230259

Published: July 1, 2024

Particulate matter with a diameter ≤2.5 μm (PM 2.5 ) poses substantial global challenge, growing recognition of pathogens contributing to diseases associated exposure PM . Recent studies have focused on , which impairs the immune cells in response microbial infections and potentially contributes development severe respiratory tract. Accordingly, changes function microecology mediated by are important factors that enhance risk pathogenesis. These garnered significant interest. In this review, we summarise recent potential mechanisms involved -mediated system disruption exacerbation pathogenesis We also discuss crucial areas for future research address gaps our understanding develop effective strategies combat adverse health effects

Language: Английский

Citations

Association of short-term PM2.5 exposure with airway innate immune response, microbiota and metabolism alterations in human airways DOI

Shuaiqi Zhao,

Huijun Li,

Fuyun Yang

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 345, P. 123435 - 123435

Published: Jan. 29, 2024

Language: Английский

Citations

Leisure-time physical activity mitigated the cognitive effect of PM2.5 and PM2.5 components exposure: Evidence from a nationwide longitudinal study DOI

Jianxiu Liu, Ruidong Liu, Yao Zhang

et al.

Environment International, Journal Year: 2023, Volume and Issue: 179, P. 108143 - 108143

Published: Aug. 15, 2023

Exposure to fine particulate matter (PM2.5) impairs cognition, while physical activity (PA) improves cognitive function. However, whether taking PA with PM2.5 exposure is still beneficial cognition remains unknown.We utilized national representative longitudinal data from the China Family Panel Study (CFPS), comprising a total sample of 108,099 2010 2018 in three waves. Cognitive performance and leisure-time were measured using standard module Godin-Shephard Leisure-Time Physical Activity Questionnaire. Gridded overall major chemical components estimated two-stage machine learning model matched each participant based on their residential location. Mixed-effect models difference-in-difference employed investigate individual joint effects PM2.5, components, cognition.Every 1 μg/m3 increase was associated -0.035 (95% confidence interval [CI] = -0.052, -0.018) point change score. All exhibited negative associations change, black carbon (BC) contributing most significant decline (β -1.025, 95% CI -1.367, -0.683). Every one-time (or one-hour) frequency time) per week an score by 0.576 (0.270) points (PA frequency: 0.544, 0.608, time: 0.248, 0.293). -0.005, -0.006, -0.003) time -0.002, -0.003, -0.001) interactive PM2.5. Increased more function low group compared those exposed high levels. Moreover, relative lower exposure, benefits physically active individuals higher attenuated but improved when no PA.Engaging provides even under although attenuates these benefits. Among all BC demonstrated hazard interaction PA. Promoting as preventive measure may offer cost-effective convenient strategy mitigate impact cognition. There excuse avoid its persist polluted environments.

Language: Английский

Citations

Distinct respiratory microbiota associates with lung cancer clinicopathological characteristics DOI

Xi Zheng,

Xingbing Lu,

Yang Hu

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 2, 2023

Commensal microbiota dysbiosis is associated with the development of lung cancer. The current studies about composition respiratory in cancer patients yielded inconsistent results. This study aimed to examine association between airway and clinicopathological characteristics.Surgically removed lesion tissues from 75 non-small cell 7 benign pulmonary diseases were analyzed by 16S rRNA sequencing. Taxonomy, relative abundance, diversity compared among different pathology TNM stages. effects antibiotic cigarette exposure on also evaluated.Bacterial abundance alpha- beta-diversity analysis showed significant differences diseases. At genus level, 13 taxa squamous carcinoma adenocarcinoma, 63 diseases, 4 adenocarcinoma reached statistical significance. In contrast, not as across No observed tissue taxonomic abundances at all levels without 3 months prior surgery. For bacterial did show smokers non-smokers.Our results confirm significantly differential microbiome taxa, some Short-term application might play a minor role molding patients. Composition are affected exposure.

Language: Английский

Citations

Real-time and specific monitoring of nitric oxide and evaluating of the oxidative stress in living cells and zebrafish under the pollutant exposure using a carbon dot-based composite fluorescent probe DOI

Meng Zhang, Changlun Tong

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 472, P. 134558 - 134558

Published: May 8, 2024

Language: Английский

Citations