ANZ Journal of Surgery, Journal Year: 2025, Volume and Issue: unknown
Published: May 3, 2025
Language: Английский
Science, Journal Year: 2024, Volume and Issue: 386(6720)
Published: Sept. 19, 2024
Twenty years after the first publication that used term microplastic, we review current understanding, refine definitions, and consider future prospects. Microplastics arise from multiple sources, including tires, textiles, cosmetics, paint, fragmentation of larger items. They are widely distributed throughout natural environment, with evidence harm at levels biological organization. pervasive in food drink have been detected human body, emerging negative effects. Environmental contamination could double by 2040, wide-scale has predicted. Public concern is increasing, diverse measures to address microplastic pollution being considered international negotiations. Clear on efficacy potential solutions now needed issue minimize risks unintended consequences.
Language: Английский
Citations
218
The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 960, P. 178276 - 178276
Published: Jan. 1, 2025
Language: Английский
Citations
3
One Earth, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
SummaryPlastics are an international governance priority because of extensive and resource-intensive production, uncontrolled environmental releases, failure to control the chemicals within materials. We examine evidence that plastics have exceeded planetary safe operating space, discussing how pollution affects multiple Earth system processes along impact pathway from resource extraction production release fate impacts. Multiple lines capture complex reality these novel entities; a single boundary quantification would be detrimental. demonstrate causal links between other problems, exacerbating consequences breaching boundaries. propose biophysically defined variables for boundaries framework as way measure, monitor, mitigate global pollution. call urgent action, recognizing not only waste management problem but integrative part climate change, biodiversity, natural-resource-use policy.
Language: Английский
Citations
16
Environment International, Journal Year: 2024, Volume and Issue: 189, P. 108791 - 108791
Published: May 31, 2024
Plastics constitute a vast array of substances, with over 16 000 known plastic chemicals, including intentionally and non-intentionally added substances. Thousands toxic ones, are extractable from plastics, however, the extent to which these compounds migrate everyday products into food or water remains poorly understood. This study aims characterize endocrine metabolism disrupting activity, as well chemical composition migrates contact articles (FCAs) four countries significant sources human exposure. Fourteen FCAs covering seven polymer types high global market shares were migrated water–ethanol mixture simulants according European regulations. The analyzed using reporter gene assays for nuclear receptors relevant health non-target analysis composition. Chemicals migrating each FCA interfered at least two receptors, predominantly targeting pregnane X receptor (24/28 migrates). Moreover, peroxisome proliferator gamma was activated by 19 out 28 migrates, though mostly lower potencies. Estrogenic antiandrogenic activity detected in eight respectively. Fewer chemicals less toxicity compared mixture. However, 73 % 15 430 features also transferred simulants, exhibited similar prevalence methanol extracts. complexity differed largely between FCAs, 8 10 631 simulants. Using stepwise partial squares regressions, we successfully narrowed down list potential active identified such triphenyl phosphate, prioritized further identification. demonstrates migration rendering beverages probable.
Language: Английский
Citations
10
Waste Management Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 100204 - 100204
Published: April 1, 2025
Language: Английский
Citations
1
Nature Medicine, Journal Year: 2024, Volume and Issue: 30(11), P. 3036 - 3037
Published: Oct. 8, 2024
Language: Английский
Citations
8
Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(11), P. 4872 - 4883
Published: March 5, 2024
G protein-coupled receptors (GPCRs) are central mediators of cell signaling and physiological function. Despite their biological significance, GPCRs have not been widely studied in the field toxicology. Herein, we investigated these as novel targets plastic chemicals using a high-throughput drug screening assay with 126 human non-olfactory GPCRs. In first-pass screen, tested activity triphenol phosphate, bisphenol A, diethyl phthalate, well three real-world mixtures extracted from food packaging covering all major polymer types. We found 11 GPCR-chemical interactions, which chemical exhibited most robust at adenosine receptor 1 (ADORA1) melatonin (MTNR1A). further confirm that polyvinyl chloride polyurethane products contain ADORA1 or MTNRA1 agonists confirmatory secondary screen pharmacological knockdown experiments. Finally, an analysis associated gene ontology terms suggests MTNR1A activation may be linked to downstream effects on circadian metabolic processes. This work highlights disruption caused by is broader than previously believed demonstrates relevance nongenomic pathways, have, thus far, remained unexplored.
Language: Английский
Citations
7
ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1563 - 1592
Published: March 26, 2025
Language: Английский
Citations
1
Nature Water, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
Language: Английский
Citations
1
Separation and Purification Technology, Journal Year: 2024, Volume and Issue: unknown, P. 129904 - 129904
Published: Sept. 1, 2024
Language: Английский
Citations
6