Molecules,
Journal Year:
2022,
Volume and Issue:
27(18), P. 5970 - 5970
Published: Sept. 14, 2022
As
a
biocompatible
biomaterial,
bagasse
xylan
(BX)
has
been
widely
used
in
the
biomedical
field.
The
low
biological
activity
of
andrographolide
(AD)
restricts
its
development,
so
AD
with
certain
anticancer
is
introduced.
We
use
chemical
modification
methods
such
as
grafting
and
esterification
to
improve
make
novel
nanomaterial.
On
basis
mixture
BX
folic
acid
(FA),
nanoderivative
xylan/andrographolide
folate-g-dimethylaminoethyl
methacrylate
(DMAEMA)/diethylene
glycol
dimethacrylate
(DEGDMA)
nanoparticles
(FA-BX/AD-g-DMAEMA/DEGDMA
NPs)
was
synthesized
by
introducing
DMAEMA
DEGDMA
monomers
through
graft
copolymerization
nanoprecipitation
method.
effects
reaction
temperature,
time,
initiator
concentration
mass
ratio
FA-BX/AD
mixed
on
rate
(GR)
were
investigated.
structure
obtained
product
characterized
FTIR,
SEM,
XRD
DTG.
Further,
molecular
docking
MTT
assays
performed
understand
possible
sites
target
proteins
product.
results
showed
that
GR
79%
under
conditions
55
mmol/L,
m
(FA-BX/AD):m
(mixed
monomer)
=
1:2,
temperature
50
°C
time
5
h.
inhibition
FA-BX/AD-g-DMAEMA/DEGDMA
NPs
human
lung
cancer
cells
(NCI-H460)
can
reach
39.77
±
5.62%,
which
about
7.6
times
higher
than
BX.
Therefore,
this
material
may
have
potential
applications
development
drug
or
carriers
functional
materials.
AAPS PharmSciTech,
Journal Year:
2024,
Volume and Issue:
25(2)
Published: Feb. 14, 2024
Abstract
Hot-melt
extrusion
(HME)
is
a
globally
recognized,
robust,
effective
technology
that
enhances
the
bioavailability
of
poorly
soluble
active
pharmaceutical
ingredients
and
offers
an
efficient
continuous
manufacturing
process.
The
twin-screw
extruder
(TSE)
extremely
resourceful
customizable
mixer
used
for
compounding
granulation
by
using
different
combinations
conveying
elements,
kneading
elements
(forward
reverse
configuration),
distributive
mixing
elements.
TSE
thus
efficiently
utilized
dry,
wet,
or
melt
not
only
to
manufacture
dosage
forms
such
as
tablets,
capsules,
granule-filled
sachets,
but
also
designing
novel
formulations
dry
powder
inhalers,
drying
units
granules,
nanoextrusion,
3D
printing,
complexation,
amorphous
solid
dispersions.
Over
past
decades,
combined
academic
industry
collaborations
have
driven
innovations
HME
technology,
which
has
resulted
in
substantial
increase
published
articles
patents.
This
article
summarizes
challenges
models
executing
scale-up.
Additionally,
it
covers
benefits
manufacturing,
process
analytical
(PAT)
considerations,
regulatory
requirements.
In
summary,
this
well-designed
review
builds
upon
our
earlier
publication,
probing
deeper
into
potential
extruders
various
new
applications.
Graphical
Carbohydrate Polymers,
Journal Year:
2024,
Volume and Issue:
333, P. 121985 - 121985
Published: Feb. 24, 2024
Sodium
Sulfobutylether-β-cyclodextrin
(SBE-β-CD)
is
a
derivative
of
β-cyclodextrin,
characterized
by
its
stereo
structure,
which
closely
resembles
truncated
cone
with
hydrophobic
internal
cavity.
The
solubility
insoluble
substances
within
the
cavity
significantly
enhanced,
reducing
contact
between
guest
and
environment.
Consequently,
SBE-β-CD
frequently
employed
as
co-solvent
stabilizer.
As
research
progresses,
it
has
been
observed
that
inclusion
reversible
competitive.
Besides,
some
complexes
undergo
distinct
physicochemical
property
alterations
compared
to
guests.
Additionally,
certain
guests
exhibit
varying
inclusions
at
different
concentrations.
These
features
have
contributed
expanding
applications.
finds
widespread
application
in
pharmaceutics
protective
agent
pKa
regulator,
pharmaceutical
analysis
chiral
substance
separator,
biomedical
engineering
for
encapsulating
dyes
modifying
sensors.
article
will
elaborate
detail
on
properties
SBE-β-CD,
encapsulation
principles,
factors
influencing
formation
complexes.
Furthermore,
review
focuses
through
pharmaceutics,
analysis,
engineering.
Finally,
prospects
potential
applications
are
discussed.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(11), P. 2627 - 2627
Published: June 3, 2024
Despite
several
decades
of
research,
the
beneficial
effect
flavonoids
on
health
is
still
enigmatic.
Here,
we
focus
antioxidant
flavonoids,
which
elementary
to
their
biological
activity.
A
relatively
new
strategy
for
obtaining
a
more
accurate
understanding
this
leverage
computational
chemistry.
This
review
systematically
presents
various
chemistry
indicators
employed
over
past
five
years
investigate
activity
flavonoids.
We
categorize
these
strategies
into
aspects:
electronic
structure
analysis,
thermodynamic
kinetic
interaction
and
bioavailability
analysis.
The
principles,
characteristics,
limitations
methods
are
discussed,
along
with
current
trends.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(13), P. 3159 - 3159
Published: July 2, 2024
Cyclodextrins
are
macrocyclic
rings
composed
of
glucose
residues.
Due
to
their
remarkable
structural
properties,
they
can
form
host–guest
inclusion
complexes,
which
is
why
frequently
used
in
the
pharmaceutical,
cosmetic,
and
food
industries,
as
well
environmental
analytical
chemistry.
This
review
presents
reports
from
2011
2023
on
quantitative
structure–activity/property
relationship
(QSAR/QSPR)
approach,
primarily
employed
predict
thermodynamic
stability
complexes.
article
extensively
discusses
significant
developments
related
size
available
experimental
data,
sets
descriptors,
machine
learning
(ML)
algorithms
used,
such
support
vector
machines,
random
forests,
artificial
neural
networks,
gradient
boosting.
As
QSAR/QPR
analysis
only
requires
molecular
structures
guests
values
constants,
this
approach
may
be
particularly
useful
for
predicting
these
complexes
with
randomly
substituted
cyclodextrins,
estimating
dependence
pH.
work
proposes
solutions
how
effectively
use
knowledge,
especially
important
researchers
who
will
deal
topic
future.
also
other
applications
ML
relation
CD
including
prediction
physicochemical
properties
development
methods
based
complexation
CDs,
optimisation
conditions
preparation
Current Research in Food Science,
Journal Year:
2022,
Volume and Issue:
5, P. 1873 - 1881
Published: Jan. 1, 2022
Molecular
simulation
is
a
new
technology
to
analyze
the
interaction
between
molecules.
This
review
mainly
summarizes
application
of
molecular
in
food
industry.
has
been
employed
assess
structural
changes
biomolecules,
components,
and
mechanism
physical
chemical
property
alterations.
These
conclusions
provide
deeper
understanding
foods,
break
through
limitations
scientific
experiments
avoid
blind
time-consuming
research.
In
this
paper,
advantages
development
trends
research
field
are
described.
methodology
can
be
used
contribute
further
studies
interactions
food,
confirm
experimental
results
ideas
for
sciences.
