Journal of Infection and Chemotherapy,
Journal Year:
2023,
Volume and Issue:
29(11), P. 1054 - 1060
Published: July 26, 2023
We
previously
reported
the
finding
of
symptom
relief
in
a
randomized
controlled
trial
with
combined
use
kakkonto
and
shosaikotokakikyosekko
added
to
conventional
treatment
patients
coronavirus
disease
2019
(COVID-19).
For
further
evaluation,
we
performed
post
hoc
analysis
focused
on
disappearance
without
recurrence,
determine
clearer
effect
Kampo
medicine.
Patients
mild
moderate
COVID-19
were
randomly
allocated
control
group
receiving
symptomatic
therapy
or
(2.5
g)
three
times
daily
addition
therapy.
The
data
161
(Kampo
group,
n
=
81;
80)
analyzed
for
time
disappearance.
Kaplan-Meier
Cox
proportional
hazard
estimates
symptoms
showed
that
all
each
targeted
this
study
disappeared
faster
than
although
not
statistically
significant
(all
cases;
ratio
[HR]
3.73,
95%
confidence
interval
[CI]
0.46-29.98,
log-rank
p
0.1763).
In
supplemental
assessment
using
covariate
adjustment
competing
risk
analysis,
fever
cases,
HR
1.62,
CI
0.99-2.64,
0.0557;
unvaccinated
1.68,
1.00-2.83,
0.0498)
shortness
breath
significantly
1.92,
1.07-3.42,
0.0278;
2.15,
1.17-3.96,
0.0141).
These
results
demonstrate
advantages
acute
COVID-19.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 31, 2023
The
World
Health
Organization
declared
that
COVID-19
is
no
longer
a
public
health
emergency
of
global
concern
on
May
5,
2023.
Post-COVID
disorders
are,
however,
becoming
more
common.
Hence,
there
lies
growing
need
to
develop
safe
and
effective
treatment
measures
manage
post-COVID
disorders.
Investigating
the
use
TCM
medicinal
foods
in
long-term
therapy
illnesses
may
be
beneficial
given
contemporary
research's
emphasis
development
foods.The
for
highlighted
this
review.
Following
discussion
history
"Medicine
Food
Homology"
theory,
pathophysiological
effects
will
briefly
reviewed.
An
analysis
their
functions
treating
then
provided
before
offering
some
insight
into
potential
directions
future
research
application.TCM
can
different
aspects
management
efficient
choice
because
they
are
typically
milder
nature
than
chronic
drug
use.
These
findings
also
applied
post-disease
similar
respiratory
Viruses,
Journal Year:
2024,
Volume and Issue:
16(3), P. 320 - 320
Published: Feb. 20, 2024
In
2020,
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2)
challenged
the
world
with
a
global
outbreak
that
led
to
millions
of
deaths
worldwide.
Coronavirus
disease
2019
(COVID-19)
is
symptomatic
manifestation
this
virus,
which
can
range
from
flu-like
symptoms
utter
clinical
complications
and
even
death.
Since
there
was
no
clear
medicine
could
tackle
infection
or
lower
its
minimal
adverse
effects
on
patients’
health,
health
organization
(WHO)
developed
awareness
programs
rate
limit
fast
spread
virus.
Although
vaccines
have
been
as
preventative
tools,
people
still
prefer
going
back
traditional
herbal
medicine,
provides
remarkable
benefits
either
prevent
viral
progression
through
different
mechanistic
pathways
relatively
insignificant
side
effects.
This
comprehensive
review
scientific
evidence
elucidating
effect
10
plants
against
SARS-CoV-2,
paving
way
for
further
studies
reconsider
plant-based
extracts,
rich
in
bioactive
compounds,
into
more
advanced
assessments
order
identify
their
impact
patients
suffering
COVID-19.
American Journal of Cancer Research,
Journal Year:
2024,
Volume and Issue:
14(5), P. 2555 - 2569
Published: Jan. 1, 2024
The
COVID-19
pandemic
has
caused
hundreds
million
cases
and
millions
death
as
well
continues
to
infect
human
life
in
the
world
since
late
of
2019.
breakthrough
infection
from
mutation
SARS-CoV-2
is
rising
even
vaccinated
population
been
increasing.
Currently,
severe
threat
posed
by
alleviated
worldwide,
situation
transitioned
coexisting
with
virus.
dietary
food
antiviral
activities
may
improve
prevent
virus
for
living
pandemic.
Teas
containing
enriched
phenolic
ingredients
such
tannins
have
reported
be
antitumor
agents
good
inhibitors
coronavirus.
This
study
developed
a
highly
sensitive
selective
ultra-high
performance
liquid
chromatography-high
resolution
mass
spectrometric
method
quantification
tannic
acids,
hydrolysable
tannin,
proanthocyanidins,
condense
teas
different
levels
fermentation.
vitro
pseudoviral
particles
(Vpp)
assay
was
used
evaluate
inhibition
various
teas.
results
current
research
demonstrate
that
are
effective
against
its
variants.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(48), P. 18735 - 18745
Published: Nov. 21, 2023
This
study
evaluated
the
chemical
composition
of
rosemary
water
extract
(RWE)
and
its
influence
on
mechanisms
by
which
SARS-CoV-2
virus
enters
into
cells
as
a
potential
route
for
reducing
risk
COVID-19
disease.
Compounds
in
RWE
were
identified
using
UHPLC-MS/MS.
The
inhibitory
effect
was
then
binding
between
spike
protein
(S-protein)
ACE2
separately
activity/availability.
Additionally,
total
phenolic
content
(TPC)
free
radical
scavenging
capacities
against
HO•,
ABTS•+,
DPPH•
assessed.
Twenty-one
compounds
tentatively
RWE,
tuberonic
acid
hexoside
first
time
rosemary.
dose
33.3
mg
equivalents
(RE)/mL
suppressed
interaction
S-protein
72.9%,
while
rosmarinic
caffeic
acids
at
3.3
μmol/mL
36
55%,
respectively.
5.0,
2.5,
0.5
RE/mL
inhibited
activity
99.5,
94.5,
68.6%,
respectively,
0.05
0.01
reduced
31
8%,
had
TPC
value
72.5
GAE/g.
results
provide
mechanistic
basis
may
reduce
infection
development
COVID-19.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(12), P. 14118 - 14122
Published: March 13, 2024
In
the
present
study,
Cinnamomum
verum
J.
Presl.
bark
essential
oil
and
its
main
component
cinnamaldehyde
was
evaluated
in
vitro
for
neuraminidase
(NA),
transmembrane
serine
protease
(TMPRSS2),
angiotensin
converting
enzyme
2
(ACE2)
inhibitory
activities.
The
chemical
composition
of
C.
confirmed
by
both
gas
chromatography–mass
spectrometry
(GC/MS),
chromatography–flame
ionization
detection
(GC-FID),
where
75.9%
(E)-cinnamaldehyde
major
component.
ACE2,
NA,
TMPRSS2
inhibitions
at
20
μg/mL
concentration,
(5
μg/mL)
were
calculated
compared
range
54.2–89.9%.
Molecular
docking
results
supported
that
(E)-cinnam-aldehyde
specific
to
ACE2
with
89.9%
inhibition.
Our
findings
suggest
further
vivo
studies
confirm
effective
safe
use
as
well
(E)-cinnamaldehyde.
