Substrate specificity study of zearalenone lactonase by analyzing interaction networks of residues near the β6-α6 region DOI
Wei Xu, Jiayi Yao,

Binbin Ouyang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 286, P. 138531 - 138531

Published: Dec. 7, 2024

Language: Английский

Biodegradation of chemical contamination by lactic acid bacteria: A biological tool for food safety DOI
Asem Mahmoud Abdelshafy,

Ahmed Rashad Mahmoud,

Talat M. Abdelrahman

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140732 - 140732

Published: Aug. 2, 2024

Language: Английский

Citations

10
Designing ASSMD Strategy for Exploring and Engineering Extreme Thermophilic Ancestral Nitrilase for Nitriles Biocatalysis DOI

Zi-Kai Wang,

Dan-Ting Feng,

Chang Su

et al.

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(18), P. 13825 - 13838

Published: Sept. 3, 2024

Enzyme thermostability is vital for prolonged reactions and reusability. Extremozymes, known their high thermal stability, have gained biocatalysis prominence. Extremozymes evolve under extreme conditions, possibly becoming extinct during the evolutionary process of adapting to current environment. Fortunately, ancestral enzyme sequence reconstruction could deduce existing enzymes through computer algorithms. Here, we designed an sequence-structure-molecule dynamics (ASSMD) strategy unveil molecular insights into in landscape. Furthermore, this approach was applied explore extremophilic nitrilase. In a dynamic flexibility trough, obtained ASR135, nitrilase capable tolerating 90 °C. Combining evolution analysis laboratory evolution, achieved further ASR135 event mutant ASR135-M4 (S97E/S101A/N124H/H155Y), which exhibited hydrolytic activity at 100 Mechanistic revealed that addition salt bridge, hydrogen bond, π-alkyl interaction tetrahedral cage strengthening hydrophobic core inside protein. These modifications resulted more robust network between four secondary structures. general, ASSMD holds potential discovering high-performance nitrilases, particularly extremozymes. Additionally, sheds light on enzyme-directed mechanisms.

Language: Английский

Citations

7
A novel glycosyltransferase from Bacillus subtilis achieves zearalenone detoxification by diglycosylation modification DOI

Yuqun Zhou,

Ji‐Guo Yang,

Yuanshan Yu

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(11), P. 6042 - 6053

Published: Jan. 1, 2024

A strain of Bacillus subtilis YQ-1 was screened from corn soil, which can convert ZEN into C 19 H 26 O 8 and diglucoside, a new glycosyltransferase mined that catalyze the glycosylation achieve effective detoxification ZEN.

Language: Английский

Citations

5
Mycotoxin Biodegradation by Bacillus Bacteria—A Review DOI Creative Commons
Thanh Nguyen, Xiaojing Chen, Linlin Ma

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(11), P. 478 - 478

Published: Nov. 4, 2024

Mycotoxins are toxic secondary metabolites produced by various types of fungi that known to contaminate food products; their presence in the chain poses significant risks human and animal health leads enormous economic losses feed industry worldwide. Ensuring safety quality detoxifying mycotoxin is therefore paramount importance. Several procedures control fungal toxins have been extensively investigated, such as preventive measures, physical chemical methods, biological strategies. In recent years, microbial degradation mycotoxins has attracted much attention due its reliability, efficiency, cost-effectiveness. Notably, bacterial species from Bacillus genus emerged promising candidates for decontamination owing diverse metabolic capabilities resilience harsh environmental conditions. This review manuscript aims provide a summary studies on biodegradation bacteria, thereby illustrating potential applications development mycotoxin-degrading products.

Language: Английский

Citations

5
A novel zearalenone lactonase can effectively mitigate zearalenone-induced reproductive toxicity in gilts DOI

Jiali Song,

Zhe Peng,

Y Y Ning

et al.

Toxicon, Journal Year: 2025, Volume and Issue: unknown, P. 108257 - 108257

Published: Jan. 1, 2025

Language: Английский

Citations

0
Characterization, mechanism, and application of aldolase: a patulin-degrading enzyme from Kluyveromyces Marxianus YG-4 DOI

Mengge Ning,

Qi Guo, Peng Guo

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106345 - 106345

Published: March 1, 2025

Language: Английский

Citations

0
Genome mining of an endophytic natural yeast isolate Rhodotorula sp. Y090 and production of the antioxidant ergothioneine DOI

Yu-Zhen Li,

Qi Wang, Cheng Cheng

et al.

Journal of Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Comparative investigation of Mycotoxin detoxification mechanisms by lactic acid bacteria (Lactobacillus species) and non-lactic acid bacteria DOI

Milad Nabgan,

Nabi Shariatifar, Tayebeh Zeinali

et al.

Journal of Food Measurement & Characterization, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Language: Английский

Citations

0
Biodegradation Characteristics and Mechanism of Aflatoxin B1 by Bacillus amyloliquefaciens from Enzymatic and Multiomics Perspectives DOI
Honghui Shi, Guoli Chang, Yuhuan Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(28), P. 15841 - 15853

Published: July 3, 2024

Aflatoxin B

Language: Английский

Citations

3
Expression, characterization, and application of an aldo-keto reductase mined from Bacillus velezensis Vel-HNGD-F2 for deoxynivalenol biodegradation DOI
Junxia Liu, Peng Li, Lizhi Xiao

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 115159 - 115159

Published: Nov. 1, 2024

Language: Английский

Citations

1