Nutrients,
Journal Year:
2019,
Volume and Issue:
11(11), P. 2648 - 2648
Published: Nov. 4, 2019
Increasing
evidence
has
demonstrated
that
amyloid-β
peptide
(Aβ),
the
hallmark
of
Alzheimer’s
disease
(AD),
evokes
oxidative
and
inflammatory
cascades,
which
ultimately
lead
to
death
neurons.
The
purpose
present
study
is
demonstrate
effect
nobiletin,
a
representative
compound
citrus
peel,
in
preventive
therapeutic
approaches
against
neuronal
damage
by
exposure
Aβ25–35.
Nobiletin
significantly
ameliorated
Aβ25–35-mediated
cell
restoring
abnormal
changes
intracellular
stress,
cycle,
nuclear
morphology,
activity
apoptotic
caspase.
Regarding
anti-inflammatory
responses,
nobiletin
suppressed
interleukin-1β,
tumor
necrosis
factor-α,
nitric
oxide
(NO),
prostaglandin
E2
production
response
Aβ
stimulation.
Moreover,
inhibited
Aβ-stimulated
inducible
NO
synthase
cyclooxygenase-2
expression,
was
attributed
blockade
factor-κB
p65
phosphorylation
its
inhibitor,
IκB-α.
Interestingly,
decreased
expression
c-Jun
N-terminal
kinase
p38
without
affecting
extracellular
signal-regulated
1/2
activation.
Taken
together,
novel
data
implicate
as
potential
candidate
for
prevention
AD
through
inhibition
apoptosis,
inflammation.
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(14), P. 3380 - 3380
Published: July 10, 2019
Alzheimer’s
disease
(AD),
which
is
characterized
by
the
presence
of
amyloid-β
(Aβ)
plaques
and
neurofibrillary
tangles,
accompanied
neurodegeneration,
most
common
form
age-related
neurodegenerative
disease.
Parkinson’s
(PD)
second
after
AD,
early
prominent
loss
dopaminergic
neurons
in
substantia
nigra
pars
compacta.
As
currently
available
treatments
are
not
able
to
significantly
alter
progression
these
diseases,
successful
therapeutic
preventive
interventions
strongly
needed.
In
course
our
survey
substances
from
natural
resources
having
anti-dementia
neuroprotective
activity,
we
found
nobiletin,
a
polymethoxylated
flavone
peel
Citrus
depressa.
Nobiletin
improved
cognitive
deficits
pathological
features
such
as
Aβ
pathology,
hyperphosphorylation
tau,
oxidative
stress,
animal
models
AD.
addition,
nobiletin
motor
PD
models.
These
observations
suggest
that
has
potential
become
novel
drug
for
treatment
prevention
diseases
AD
PD.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Oct. 24, 2022
Neuroinflammation
is
the
fundamental
immune
response
against
multiple
factors
in
central
nervous
system
and
characterized
by
production
of
inflammatory
mediators,
activated
microglia
astrocytes,
recruitment
innate
adaptive
cells
to
sites,
that
contributes
pathological
process
related
brain
diseases,
such
as
Alzheimer’s
disease,
Parkinson’s
depression,
stroke.
Flavonoids,
a
species
important
natural
compounds,
have
been
widely
revealed
alleviate
neuroinflammation
inhibiting
pro-inflammatory
elevating
secretion
anti-inflammatory
factors,
modulating
polarization
astrocyte,
mainly
via
suppressing
activation
NLRP3
inflammasome,
well
NF-κB,
MAPK,
JAK/STAT
pathways,
promoting
Nrf2,
AMPK,
BDNF/CREB,
Wnt/β-Catenin,
PI3k/Akt
signals
SIRT1-mediated
HMGB1
deacetylation.
This
review
will
provide
latest
comprehensive
knowledge
on
therapeutic
benefits
mechanisms
flavonoids
neuroinflammation,
might
be
developed
into
food
supplements
or
lead
compounds
for
neuroinflammation-associated
disorders.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(11), P. 9236 - 9236
Published: May 25, 2023
Flavonoids
are
polyphenolic
phytochemical
compounds
found
in
many
plants,
fruits,
vegetables,
and
leaves.
They
have
a
multitude
of
medicinal
applications
due
to
their
anti-inflammatory,
antioxidative,
antiviral,
anticarcinogenic
properties.
Furthermore,
they
also
neuroprotective
cardioprotective
effects.
Their
biological
properties
depend
on
the
chemical
structure
flavonoids,
mechanism
action,
bioavailability.
The
beneficial
effects
flavonoids
been
proven
for
variety
diseases.
In
last
few
years,
it
is
demonstrated
that
mediated
by
inhibiting
NF-κB
(Nuclear
Factor-κB)
pathway.
this
review,
we
summarized
some
most
common
diseases,
such
as
cancer,
cardiovascular,
human
neurodegenerative
Here,
collected
all
recent
studies
describing
protective
prevention
role
derived
from
plants
specifically
focusing
action
signaling
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(1), P. 180 - 180
Published: Jan. 12, 2023
Alzheimer’s
disease
(AD)
is
a
neurodegenerative
disorder
characterized
by
progressive
memory
loss
and
cognitive
decline.
Although
substantial
research
has
been
conducted
to
elucidate
the
complex
pathophysiology
of
AD,
therapeutic
approach
still
limited
efficacy
in
clinical
practice.
Oxidative
stress
(OS)
established
as
an
early
driver
several
age-related
diseases,
including
neurodegeneration.
In
increased
levels
reactive
oxygen
species
mediate
neuronal
lipid,
protein,
nucleic
acid
peroxidation,
mitochondrial
dysfunction,
synaptic
damage,
inflammation.
Thus,
identification
novel
antioxidant
molecules
capable
detecting,
preventing,
counteracting
AD
onset
progression
utmost
importance.
However,
although
studies
have
published,
comprehensive
up-to-date
overviews
principal
anti-AD
agents
harboring
properties
remain
scarce.
this
narrative
review,
we
summarize
role
vitamins,
minerals,
flavonoids,
non-flavonoids,
mitochondria-targeting
molecules,
organosulfur
compounds,
carotenoids
non-enzymatic
antioxidants
with
diagnostic,
preventative,
potential,
thereby
offering
insights
into
relationship
between
OS
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 636 - 636
Published: Jan. 14, 2025
Neuroinflammation
is
involved
in
various
neurological
and
neurodegenerative
disorders
which
the
activation
of
microglia
one
key
factors.
In
this
study,
we
examined
anti-inflammatory
effects
flavonoids
nobiletin
(5,6,7,8,3′,4′-hexamethoxyflavone)
eriodictyol
(3′,4′,5,7-tetraxydroxyflavanone)
on
human
cell
line
stimulated
by
either
lipopolysaccharide
(LPS),
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
full-length
Spike
protein
(FL-Spike),
or
mycotoxin
ochratoxin
A
(OTA).
Human
were
preincubated
with
(10,
50,
100
µM)
for
h,
following
which,
they
24
h.
The
inflammatory
mediators
interleukin-1
beta
(IL-1β),
chemokine
(C-X-C
motif)
ligand
8
(CXCL8),
IL-6,
matrix
metalloproteinase-9
(MMP-9)
quantified
culture
supernatant
enzyme-linked
immunosorbent
assay
(ELISA).
Both
significantly
inhibited
LPS,
FL-Spike,
OTA-stimulated
release
IL-1β,
CXCL8,
MMP-9
at
50
µM,
while,
most
cases,
was
also
effective
10
pronounced
reductions
µM.
These
findings
suggest
that
both
are
potent
inhibitors
pathogen-stimulated
microglial
mediators,
highlighting
their
potential
therapeutic
application
neuroinflammatory
diseases,
such
as
long
COVID.
Biomedicines,
Journal Year:
2020,
Volume and Issue:
8(5), P. 110 - 110
Published: May 5, 2020
Cancer
therapy
is
a
growing
field,
and
annually,
high
number
of
research
performed
to
develop
novel
antitumor
drugs.
Attempts
find
new
drugs
continue,
since
cancer
cells
are
able
acquire
resistance
conventional
Natural
chemicals
can
be
considered
as
promising
candidates
in
the
field
due
their
multiple-targeting
capability.
The
nobiletin
(NOB)
ubiquitous
flavone
isolated
from
Citrus
fruits.
NOB
has
variety
pharmacological
activities,
such
antidiabetes,
antioxidant,
anti-inflammatory,
hepatoprotective,
neuroprotective.
Among
them,
activity
been
under
attention
over
recent
years.
In
this
review,
we
comprehensively
describe
efficacy
therapy.
induces
apoptosis
cell
cycle
arrest
cells.
It
suppress
migration
invasion
via
inhibition
epithelial-to-mesenchymal
transition
(EMT)
EMT-related
factors
TGF-β,
ZEB,
Slug,
Snail.
Besides,
inhibits
oncogene
STAT3,
NF-κB,
Akt,
PI3K,
Wnt,
so
on.
Noteworthy,
onco-suppressor
microRNA-7
-200b
undergo
upregulation
by
These
pathways
mechanisms
discussed
review.
