Constructing and deconstructing the bacterial cell wall DOI Open Access
Jed F. Fisher, Shahriar Mobashery

Protein Science, Journal Year: 2019, Volume and Issue: 29(3), P. 629 - 646

Published: Oct. 6, 2019

The history of modern medicine cannot be written apart from the antibiotics. Antibiotics are cytotoxic secondary metabolites that isolated Nature. antibacterial antibiotics disproportionately target bacterial protein structure is distinct eukaryotic structure, notably within ribosome and pathways for cell-wall biosynthesis (for which there not a counterpart). This review focuses on pre-eminent class antibiotics-the β-lactams, exemplified by penicillins cephalosporins-from perspective evolving mechanisms resistance. mechanism action β-lactams destruction. In monoderm (single membrane, Gram-positive staining) pathogen Staphylococcus aureus dominant resistance expression β-lactam-unreactive transpeptidase enzyme functions in construction. diderm (dual Gram-negative Pseudomonas aeruginosa (among several) hydrolytic destroys critical β-lactam ring antibiotic. key sensing used P. monitoring molecular difference between construction deconstruction. both bacteria, manifested only when bacteria detect presence β-lactams. summarizes how sensed manifested, with expectation preventing these processes will to future chemotherapeutic control multidrug resistant bacteria.

Language: Английский

Antimicrobial Stewardship: Fighting Antimicrobial Resistance and Protecting Global Public Health DOI Creative Commons
Md Anwarul Azim Majumder, Sayeeda Rahman, Damian Cohall

et al.

Infection and Drug Resistance, Journal Year: 2020, Volume and Issue: Volume 13, P. 4713 - 4738

Published: Dec. 1, 2020

Abstract: Antimicrobial resistance (AMR) is a serious threat to global public health. It increases morbidity and mortality, associated with high economic costs due its health care burden. Infections multidrug-resistant (MDR) bacteria also have substantial implications on clinical outcomes. Moreover, increased indiscriminate use of antibiotics during the COVID-19 pandemic will heighten bacterial ultimately lead more deaths. This review highlights AMR's scale consequences, importance, an antimicrobial stewardship program (ASP) fight protect (AMS), organizational or system-wide health-care strategy, designed promote, improve, monitor, evaluate rational antimicrobials preserve their future effectiveness, along promotion protection ASP has been very successful in promoting antimicrobials' appropriate by implementing evidence-based interventions. The "One Health" approach, holistic multisectoral needed address rising threat. AMS practices, principles, interventions are critical steps towards containing mitigating AMR. Evidence-based policies must guide vaccination protocols, professionals' education, public's awareness about Keywords: antibiotics, resistance, multidrug-resistant, program, One Health,

Language: Английский

Citations

441
A broad-spectrum antibiotic adjuvant reverses multidrug-resistant Gram-negative pathogens DOI
Meirong Song, Yuan Liu, Xiaoyong Huang

et al.

Nature Microbiology, Journal Year: 2020, Volume and Issue: 5(8), P. 1040 - 1050

Published: May 18, 2020

Language: Английский

Citations

378
α-Pinene: A never-ending story DOI Creative Commons

Martina Allenspach,

Christian Steuer

Phytochemistry, Journal Year: 2021, Volume and Issue: 190, P. 112857 - 112857

Published: Aug. 5, 2021

α-Pinene represents a member of the monoterpene class and is highly distributed in higher plants like conifers, Juniper ssp. Cannabis has been used to treat respiratory tract infections for centuries. Furthermore, it plays crucial role fragrance flavor industry. In vitro assays have shown an enantioselective profile (+)- (-)-α-pinene antibacterial insecticidal activity, respectively. Recent research pre-validated biological structures synthesize new chemical entities with pharmacological herbicidal activities. summary, this review focuses on recent literature covering synthetic pathways compounds scaffold hopping based α-pinene core domaine, as well (enantioselective) activities α-pinene. approaches authenticity control essential oils their enantiomeric are also presented.

Language: Английский

Citations

181
Novel non-nucleic acid targets detection strategies based on CRISPR/Cas toolboxes: A review DOI
X. Cheng, Yaru Li,

Jun Kou

et al.

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 215, P. 114559 - 114559

Published: July 13, 2022

Language: Английский

Citations

127
The spread of antibiotic resistance to humans and potential protection strategies DOI Creative Commons
Dong Ding, Bin Wang, Xiaoan Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 254, P. 114734 - 114734

Published: March 10, 2023

Antibiotic resistance is currently one of the greatest threats to human health. Widespread use and residues antibiotics in humans, animals, environment can exert selective pressure on antibiotic bacteria (ARB) gene (ARG), accelerating flow resistance. As ARG spreads population, burden humans increases, which may have potential health effects people. Therefore, it critical mitigate spread reduce load humans. This review briefly described information global consumption national action plans (NAPs) combat provided a set feasible control strategies for transmission ARB three areas including (a) Reducing colonization capacity exogenous ARB, (b) Enhancing mitigating horizontal transfer (HGT) ARG, (c) Reversing With hope achieving interdisciplinary one-health prevention bacterial

Language: Английский

Citations

117
Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria DOI Creative Commons
Ronit Vogt Sionov, Doron Steinberg

Microorganisms, Journal Year: 2022, Volume and Issue: 10(6), P. 1239 - 1239

Published: June 16, 2022

Chronic and recurrent bacterial infections are frequently associated with the formation of biofilms on biotic or abiotic materials that composed mono- multi-species cultures bacteria/fungi embedded in an extracellular matrix produced by microorganisms. Biofilm is, among others, regulated quorum sensing (QS) which is interbacterial communication system usually two-component systems (TCSs) secreted autoinducer compounds activate signal transduction pathways through interaction their respective receptors. Embedded biofilms, bacteria protected from environmental stress stimuli, they often show reduced responses to antibiotics, making it difficult eradicate infection. Besides penetration antibiotics intricate structure sessile biofilm-embedded metabolic activity them intrinsically less sensitive antibiotics. Moreover, express elevated levels efflux pumps extrude thereby reducing intracellular levels. Some involved secretion QS biofilm-related materials, besides being important for removing toxic substances bacteria. pump inhibitors (EPIs) have been shown both prevent biofilm sensitize suggesting a relationship between these processes. Additionally, quenchers may affect antibiotic susceptibility. Thus, targeting elements regulate might be promising approach combat antibiotic-resistant infections.

Language: Английский

Citations

113
β-Lactam antibiotic targets and resistance mechanisms: from covalent inhibitors to substrates DOI
Montserrat Mora-Ochomogo, Christopher T. Lohans

RSC Medicinal Chemistry, Journal Year: 2021, Volume and Issue: 12(10), P. 1623 - 1639

Published: Jan. 1, 2021

Overview of β-lactam antibiotics and the proteins with which they covalently interact, focusing on penicillin-binding serine β-lactamases.

Language: Английский

Citations

112
Antibiotic Adjuvants: A Versatile Approach to Combat Antibiotic Resistance DOI Creative Commons

Geetika Dhanda,

Yash Acharya, Jayanta Haldar

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(12), P. 10757 - 10783

Published: March 14, 2023

The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging even to last resort antibiotics. drug discovery process often stalled by stringent cut-offs required for effective design. In such a scenario, it prudent delve into varying mechanisms existing antibiotics and target them improve efficacy. Nonantibiotic compounds called adjuvants which bacterial can be used in combination obsolete drugs an improved therapeutic regime. field "antibiotic adjuvants" has gained significant traction recent years where other than β-lactamase inhibition have been explored. This review discusses multitude acquired inherent employed bacteria resist action. major focus this how these use adjuvants. Different types direct acting indirect breakers are discussed including enzyme inhibitors, efflux pump inhibitors teichoic acid synthesis, cellular processes. multifaceted class membrane-targeting poly pharmacological effects potential host immune-modulating also reviewed. We conclude providing insights about challenges preventing clinical translation different classes adjuvants, especially membrane-perturbing compounds, framework possible directions pursued fill gap. Antibiotic–adjuvant combinatorial therapy indeed immense as upcoming orthogonal strategy conventional discovery.

Language: Английский

Citations

89
The Evolution of Antimicrobial Resistance in Acinetobacter baumannii and New Strategies to Fight It DOI Creative Commons
Viola Camilla Scoffone, Gabriele Trespidi, Giulia Barbieri

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 85 - 85

Published: Jan. 14, 2025

Acinetobacter baumannii is considered one of the prioritized ESKAPE microorganisms for research and development novel treatments by World Health Organization, especially because its remarkable persistence drug resistance. In this review, we describe how can be acquired enzymatic degradation antibiotics, target site modification, altered membrane permeability, multidrug efflux pumps, their ability to form biofilms. Also, evolution resistance in A. baumannii, which mainly driven mobile genetic elements, reported, with particular reference plasmid-associated resistance, islands, insertion sequences. Finally, an overview existing, new, alternative therapies provided.

Language: Английский

Citations

5
Addressing the global challenge of bacterial drug resistance: insights, strategies, and future directions DOI Creative Commons
Arun Karnwal,

Amar Yasser Jassim,

Ameer A. Mohammed

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

The COVID-19 pandemic underscored bacterial resistance as a critical global health issue, exacerbated by the increased use of antibiotics during crisis. Notwithstanding pandemic's prevalence, initiatives to address medication have been inadequate. Although an overall drop in worldwide antibiotic consumption, total usage remains substantial, requiring rigorous regulatory measures and preventive activities mitigate emergence resistance. National Action Plans (NAPs) implemented worldwide, significant disparities persist, particularly low- middle-income countries (LMICs). Settings such farms, hospitals, wastewater treatment facilities, agricultural environments include presence Antibiotic Resistant Bacteria (ARB) antibiotic-resistance genes (ARG), promoting propagation Dietary modifications probiotic supplementation shown potential reshaping gut microbiota reducing gene prevalence. Combining with adjuvants or bacteriophages may enhance efficacy development. Novel therapeutic approaches, tailored antibiotics, monoclonal antibodies, vaccines, nanoparticles, offer alternate ways addressing In spite advancements next-generation sequencing analytics, gaps persist comprehending role regulating Effectively tackling requires robust policy interventions targeting root causes while minimizing public risks. This review provides information for developing strategies protocols prevent colonization, microbiome resilience, spread

Language: Английский

Citations

2