Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 17, 2024
Abstract
Nonmetal‐containing
peroxidase
enzymes,
including
glutathione
(GPx),
and
peroxiredoxins,
control
cellular
redox
levels
by
catalyzing
the
reduction
of
H
2
O
.
The
remarkably
higher
reactivity
GPx
enzyme
as
compared
to
fully
dissociated
synthetic
selenolate/thiolate
molecule
is
probably
due
dual‐attack
on
peroxide
bond
(HO
1
−O
H)
enzyme;
first
one
a
nucleophilic
attack
moiety
atom
second
at
acidic
“parked
proton”
from
Trp
or
His
residue
present
enzyme's
active
site,
leading
facile
cleavage
O−O
bond.
Herein,
we
report
two
compounds
(
),
having
selenolate
(Se
−
)
proton
donor
(imidazolium
−COOH
group)
moieties,
which
showed
excellent
GPx‐like
activity
via
combined
effect
that
donates
electrons
antibonding
(σ*)
orbital
imidazolium
carboxylic
acid
side
chain
forms
strong
H‐bonding
with
facilitates
more
efficiently.
exhibit
remarkable
ability
in
protecting
Cu(I)‐complex
[TpmCu(CH
3
CN)]
+
9
against
acting
sacrificial
antioxidant,
thereby
preventing
metal‐mediated
ROS
production.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 4, 2025
Nonlinear
effects
(NLEs)
serve
as
a
widespread
tool
in
the
study
of
asymmetric
catalytic
reactions.
However,
due
to
diversity
ligand-metal
coordination
modes,
information
obtained
solely
from
linear
relationship
between
ee
values
ligands
and
products
complex
systems
is
often
indirect.
Here,
we
report
precise
method
that
directly
connects
metal
complexes
products,
with
purpose
determining
active
species
occur
systems.
Through
an
in-depth
analysis
mechanism
our
previous
copper-catalyzed
esterification
reactions,
find
intrinsic
key
(LLCuI)
within
this
traditionally
non-linear
system.
This
holds
promise
powerful
for
exploration
catalysis
mechanisms,
heralding
new
avenues
understanding
application
processes.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(21), P. 7349 - 7349
Published: Oct. 30, 2023
Selenium
is
an
essential
trace
element
in
living
organisms,
and
present
selenoenzymes
with
antioxidant
activity,
like
glutathione
peroxidase
(GPx)
thioredoxin
reductase
(TrxR).
The
search
for
small
selenium-containing
molecules
that
mimic
a
strong
field
of
research
organic
medicinal
chemistry.
In
this
review,
we
review
the
synthesis
bioassays
new
known
organoselenium
compounds
covering
last
five
years.
A
detailed
description
synthetic
procedures
performed
vitro
vivo
presented,
highlighting
most
active
each
series.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(42), P. 39535 - 39545
Published: Oct. 12, 2023
Herein,
we
describe
a
urea
hydrogen
peroxide-mediated
sustainable
protocol
for
the
synthesis
of
selenylated
imidazo[2,1-b]thiazole
by
using
half
molar
equivalent
diorganyl
diselenides
in
ethyl
lactate
as
greener
solvent.
The
reaction
features
high
yields,
easy
performance
on
gram
scale,
metal-free
conditions,
well
applicability
to
imidazopyridine
and
imidazopyrimidine.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(7), P. 6396 - 6405
Published: Feb. 13, 2025
Dimethoxynaphthalene
peri-diselenide-based
BODIPY
(4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)
probe
has
been
synthesized.
The
demonstrated
selectivity
and
sensitivity
for
hydrogen
peroxide
(H2O2)
tert-butylhydroperoxide
(t-BuOOH),
hydroxyl
radical
(•OH),
peroxynitrite
ion
(ONOO–)
detection
reversibility
upon
treatment
with
glutathione.
limits
of
the
were
observed
to
be
0.40
μM
H2O2,
0.41
t-BuOOH,
0.95
•OH,
0.46
ONOO–,
respectively.
A
proposed
mechanism
"turn-on"
event
suggested
corroborated
by
spectroscopic
computational
data.
It
that
electron
transfer
occurred
from
Se
center
moiety,
followed
photoinduced
(PET)
mechanism.
ChemBioChem,
Journal Year:
2024,
Volume and Issue:
25(4)
Published: Jan. 31, 2024
The
synthesis
of
diarylamine-based
organoselenium
compounds
via
the
nucleophilic
substitution
reactions
has
been
described.
Symmetrical
monoselenides
and
diselenides
were
conveniently
synthesized
by
reduction
their
corresponding
selenocyanates
using
sodium
borohydride.
Selenocyanates
obtained
from
2-chloro
acetamides
displacement
with
potassium
selenocyanate.
Selenides
treating
in
situ
generated
butyl
selenolate
as
nucleophile.
Further,
newly
evaluated
for
glutathione
peroxidase
(GPx)-like
activity
thiophenol
assay.
This
study
revealed
that
methoxy-substituted
showed
significant
effect
on
GPx-like
activity.
catalytic
parameters
most
efficient
catalysts
also
determined.
anti-ferroptotic
all
GPx-mimics
a
4-OH-tamoxifen
(TAM)
inducible
GPx4
knockout
cell
line
liproxstatin
standard.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(19), P. 14328 - 14340
Published: Sept. 16, 2024
Here,
the
synthesis
and
catalytic
activities
of
benzoimidazole-derived
organoselenium
compounds
have
been
explored.
The
synthesized
bis(2-benzoimidazolyl)
diselenide,
having
increased
Lewis
acidity
on
selenium
center,
outperforms
simple
phenyl
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(9)
Published: Feb. 27, 2024
Abstract
In
the
present
study,
synthesis
of
bis
‐naphthol
based
organoselenium
compounds
has
been
described.
The
synthetic
strategy
involves
electrophilic
aromatic
addition
alkyl/aryl
selenium
species
at
electron
rich
center
2,7‐dihydroxynaphthalene.
reaction
with
selenylating
reagents
in
situ
generated
by
potassium
persulphate
and
diselenides
produced
desired
selenides.
Synthesized
were
studied
for
their
glutathione
peroxidase
(GPx)‐like
antioxidant
activities
using
thiophenol
assay.
It
was
observed
that
all
exhibited
greater
GPx‐like
activity
than
diphenyl
diselenide
used
as
reference.
Further,
these
GPx
mimics
introduced
antibacterial
properties
against
biofilm
formation
Bacillus
subtilis
Pseudomonas
aeruginosa
.
To
support
experimental
details,
molecular
docking
studies
also
performed
to
elucidate
silico
interactions
between
active
sites
proteins
TsaA
LasR
found
,
respectively.
minimum
inhibitory
concentration
assay
antioxidants
Additionally,
hemolytic
carried
out
check
impact
on
red
blood
cells.
Cytotoxicity
assessments
have
MTT
