Ketogenic nutritional therapy (KeNuT)—a multi-step dietary model with meal replacements for the management of obesity and its related metabolic disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)—diet therapies in endocrinology and metabolism

Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: 47(3), P. 487 - 500

Published: Jan. 18, 2024

Abstract Purpose The ketogenic nutritional therapy (KeNuT) is an effective dietary treatment for patients with obesity and obesity-related comorbidities, including type 2 diabetes, dyslipidaemia, hypertension, coronary artery disease, some of cancers. However, to date official document on the correct prescription diet, validated by authoritative societies in nutrition or endocrine sciences, missing. It important emphasize that requires proper medical supervision patient selection, due complex biochemical implications ketosis need a strict therapeutic compliance, experienced nutritionist personalization whole protocol. Methods This practical guide provides update main clinical indications contraindications meal replacements its mechanisms action. In addition, various phases protocol involving replacements, monitoring, management potential side effects, are also discussed. Conclusion will help healthcare provider acquire necessary skills provide comprehensive care overweight, diseases, using multistep treatment, recognized Club Italian Society Endocrinology (SIE)—Diet Therapies Metabolism.

Language: Английский

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The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool?

Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 157 - 157

Published: Jan. 22, 2021

Chronic inflammation and increased oxidative stress are contributing factors to many non-communicable diseases. A growing body of evidence indicates that dietary nutrients can activate the immune system may lead overproduction pro-inflammatory cytokines. Fatty acids as macronutrients key players for immunomodulation, with n-3 polyunsaturated fatty having most beneficial effect, while polyphenols carotenoids seem be promising antioxidants. Psoriasis is a chronic, immune-mediated inflammatory disease multifactorial etiology. Obesity major risk factor psoriasis, which leads worse clinical outcomes. Weight loss interventions and, generally, regimens such gluten-free Mediterranean diet or supplement use potentially improve psoriasis’ natural course response therapy. However, data about more sophisticated nutritional patterns, ketogenic, very low-carb specific macro- micro-nutrient substitution, scarce. This review aims present effect strictly structured nutrients, known affect glucose/lipid metabolism insulin responses, on chronic immunity, discuss utility possible therapeutic tools psoriasis psoriatic arthritis.

Language: Английский

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Could very low-calorie ketogenic diets turn off low grade inflammation in obesity? Emerging evidence

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(26), P. 8320 - 8336

Published: April 4, 2022

Obesity is an emerging non-communicable disease associated with chronic low-grade inflammation and oxidative stress, compounded by the development of many obesity-related diseases, such as cardiovascular disease, type 2 diabetes mellitus, a range cancers. Originally developed for treatment epilepsy in drug non-responder children, ketogenic diet (KD) being increasingly used including obesity conditions. The KD dietary pattern characterized high fat intake, moderate to low protein consumption, very carbohydrate intake (<50 g) that has proved be effective weight-loss tool. In addition, it also appears intervention capable improving inflammatory state stress individuals means several mechanisms. main activity been linked mitochondrial function decreasing stress. β-hydroxybutyrate, most studied ketone body, shown reduce production reactive oxygen species, respiration. KDs exert anti-inflammatory through mechanisms, e.g., inhibiting activation nuclear factor kappa-light-chain-enhancer activated B cells, nucleotide-binding, leucine-rich-containing family, pyrin domain-containing-3, histone deacetylases. Given rising interest topic, this review looks at underlying antioxidant mechanisms their possible recruitment disorders.

Language: Английский

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The Link Between Obesity and the Skin

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: March 10, 2022

Obesity as a multi-organ disease that affects the entire human organism. Notably, skin is no exclusion from this postulate. Skin changes in obese patients have been widely studied with regards to mechanical friction, infections, and hypertrophic conditions, such acanthosis nigricans and, most commonly, fibromas (skin tags). Almost 60-70% of present variety changes. Herein, we discuss our own experience review complex obesity. The role metabolic syndrome obesity are responsible for epidemiological prevalence involved pathogenesis chronic inflammatory diseases, psoriasis, atopic dermatitis, malignancies. Here, comment on nutritional interventions these it has proven low-calorie diet weight loss related improvement diseases. readership paper will receive up-to-date overview connection between practical importance any clinician working field.

Language: Английский

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The Impact of Diet and Physical Activity on Psoriasis: A Narrative Review of the Current Evidence

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 840 - 840

Published: Feb. 7, 2023

Psoriasis is an inflammatory disease with strong genetic links and numerous features of autoimmunity that are also influenced by environment lifestyle, including nutritional factors physical activity (PA), regards to the condition patients. Recent reports in field nutrigenomics indicate a significant impact nutrients modulating microRNAs. However, few studies have evaluated effect systems PA on treating psoriasis. This narrative review updates information regarding current dietary recommendations for individuals psoriasis discusses role diet prevention treatment. Application nutrigenetics therapy discussed. The PubMed Google Scholar databases were searched using MeSH terms “nutrigenomics”, “dietetics”, “diet therapy”, “diet”, “physical activity”, “exercise” conjunction “psoriasis” “dermatology”. Evidence has shown patients should personalized anti-inflammatory diet. less physically active; most performed exercises low-to-moderate intensity likely undertake regular exercise. Identifying nutrigenomic discoveries lifestyle interventions associated can help physicians therapists develop educational programs manage protect against disease.

Language: Английский

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The Effect of a Ketogenic Diet versus Mediterranean Diet on Clinical and Biochemical Markers of Inflammation in Patients with Obesity and Psoriatic Arthritis: A Randomized Crossover Trial

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2475 - 2475

Published: Feb. 20, 2024

The effect of different diet patterns on psoriasis (PSO) and psoriatic arthritis (PSA) is unknown. Τhe aim our study was to evaluate the effectiveness a Mediterranean (MD) Ketogenic (KD), in patients with PSO PSA. Twenty-six were randomly assigned start either MD or KD for period 8 weeks. After 6-week washout interval, two groups crossed over other type At end this study, resulted significant reduction weight (p = 0.002, p < 0.001, respectively), BMI 0.006, waist circumference (WC) total fat mass 0.007, visceral 0.01, comparison baseline. KD, displayed Psoriasis Area Severity Index (PASI) 0.04), Disease Activity Psoriatic Arthritis (DAPSA) 0.004), interleukin (IL)-6 0.047), IL-17 0.042), IL-23 0.037), whereas no differences observed these markers after > 0.05), compared 22-week MD–KD program PSA led beneficial results inflammation disease activity, which mainly attributed KD.

Language: Английский

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Managing the Patient with Psoriasis and Metabolic Comorbidities

American Journal of Clinical Dermatology, Journal Year: 2024, Volume and Issue: 25(4), P. 527 - 540

Published: May 15, 2024

Epidemiological data demonstrate strong associations between psoriasis and metabolic comorbidities, including obesity, hypertension, diabetes mellitus, dyslipidemia, non-alcoholic fatty liver disease. The presence of comorbidities significantly influences the selection effectiveness pharmacological treatments. Some drugs should be prescribed with caution in patients because an increased risk adverse events, while others could have a reduced effectiveness. aim this narrative review is to highlight challenges that healthcare professionals may face regarding management comorbidities. In first part article, epidemiological association their pathogenetic mechanisms summarized. second describes efficacy safety profile conventional biologic selected disease/hepatic steatosis, diabetes. Finally, role non-pharmacological interventions, such as diet, alcohol abstinence, physical activity, smoking avoidance discussed. conclusion, choice best approach manage encompass both tailored individualized interventions.

Language: Английский

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Nutritional Therapy in Persons Suffering from Psoriasis

Nutrients, Journal Year: 2021, Volume and Issue: 14(1), P. 119 - 119

Published: Dec. 28, 2021

Psoriasis is a chronic inflammatory skin disease. Immunological, genetic, and environmental factors, including diet, play part in the pathogenesis of psoriasis. Metabolic syndrome or its components are frequent co-morbidities persons with A change eating habits can improve quality life patients by relieving lesions reducing risk other diseases. low-energy diet recommended for excess body weight. Persons suffering from psoriasis should limit intake saturated fatty acids replace them polyunsaturated omega-3 family, which have an anti-inflammatory effect. In therapy psoriasis, introduction antioxidants such as vitamin A, C, E, carotenoids, flavonoids, selenium extremely important. Vitamin D supplementation also recommended. Some authors suggest that alternative diets positive effect on course These include: gluten-free vegetarian Mediterranean diet. Diet be tailored to pharmacological treatment. For instance, folic acid introduced taking methotrexate. The purpose this paper discuss detail nutritional recommendations

Language: Английский

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The Effect of Ketogenic Diet on Inflammatory Arthritis and Cardiovascular Health in Rheumatic Conditions: A Mini Review

Frontiers in Medicine, Journal Year: 2021, Volume and Issue: 8

Published: Dec. 14, 2021

The principle of ketogenic diet (KD) is restriction carbohydrates to a maximum 5–10% the total daily caloric intake, aiming at shifting body metabolism toward ketone bodies. Different studies suggested promising results KD help patients lose weight, reduce insulin requirements in diabetes, supplement cancer protocols, treat neurological conditions and optimize control metabolic cardiovascular diseases. However, literature about anti-inflammatory properties rheumatic diseases still limited. beneficial effects weight loss with inflammatory arthritis can be explained by biomechanical biochemical factors. Obesity associated macrophage activation production pro-inflammatory cytokines including TNF-α, IL-1b, IL-6. clinical effect may primarily attributed improvement sensitivity. Insulin resistance an increase IL-1α, IL-1β, IL-6, leptin. Moreover, reduction body's adipose tissue account for part impact on health. In rheumatoid arthritis, fasting was shown effective reducing disease symptoms, possibly through β-hydroxybutyrate (BHB), main body. BHB exert inhibitory also IL-17 intermittent improved manifestations psoriatic arthritis. ankylosing spondylitis, current doesn't allow draw conclusion KD. Future prospective will needed elucidate potential specific domains outcomes

Language: Английский

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Psoriasis immunometabolism: progress on metabolic biomarkers and targeted therapy

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: June 19, 2023

Psoriasis is a common inflammatory disease that affects mainly the skin. However, moderate to severe forms have been associated with several comorbidities, such as psoriatic arthritis, Crohn’s disease, metabolic syndrome and cardiovascular disease. Keratinocytes T helper cells are dominant cell types involved in psoriasis development via complex crosstalk between epithelial cells, peripheral immune residing Immunometabolism has emerged potent mechanism elucidating aetiopathogenesis of psoriasis, offering novel specific targets diagnose treat early. The present article discusses reprogramming activated tissue-resident memory keratinocytes skin, presenting biomarkers therapeutic targets. In phenotype, glycolysis dependent characterized by disruptions TCA cycle, amino acid metabolism fatty metabolism. Upregulation mammalian target rapamycin (mTOR) results hyperproliferation cytokine secretion keratinocytes. Metabolic through inhibition affected pathways dietary restoration imbalances may thus opportunity achieve long-term management improved quality life minimum adverse effects.

Language: Английский

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