Limonin Exhibits Anti-Inflammatory Effects by Inhibiting mTORC1 and Mitochondrial Reactive Oxygen Species in Psoriatic-like Skin Inflammation DOI Creative Commons

Seung Taek Lee,

Jong Yeong Lee,

Ha Eun Kim

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1541 - 1541

Published: Dec. 16, 2024

Psoriasis is a chronic inflammatory skin disorder characterized by abnormal immune responses and keratinocyte hyperproliferation. Limonin, bioactive compound found in citrus fruits, has anti-inflammatory properties various models; however, its effects on psoriasis are not fully understood. We investigated the therapeutic potential of limonin 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse model. Mice were treated with TPA to induce psoriasis-like lesions, followed intraperitoneal administration (200 or 400 μg/mouse) for six days. The results showed that improved psoriasis-related symptoms model suppressing mRNA expression pro-inflammatory cytokines inflammation-related antimicrobial peptides regulating expansion myeloid cells T cells. Specifically, reduced glucose uptake oxidative phosphorylation shift metabolic program inflamed mice. Limonin activates AMPK proteins related mTOR inhibition, thereby signaling pathway. It also inhibits mitochondrial mass ROS production, preventing development dysfunctional mitochondria Overall, modulates key pathways inflammation health psoriasis. Therefore, it promising natural candidate treatment diseases.

Language: Английский

Obesity mediates the association between psoriasis and diabetes incidence: a population-based study DOI Creative Commons

Zuojiao Xu,

Kaihua Ma,

Yujia Zhai

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 8, 2025

The aim of this study was to explore the association between psoriasis and diabetes assess potential moderating role obesity in relationship. involving data from 21,835 NHANES participants during 2003-2006 2009-2014. analysis included body mass index (BMI), as well information about obtained questionnaires. employed weighted logistic regression examine diabetes. nonlinear relationship obesity, diabetes, explored through smooth curve fitting, stratified by age gender. In addition, authors conducted mediation analysis, which suggested that partially mediated prevalence. After adjusting for relevant variables, we found individuals with had a significantly higher incidence (OR = 1.48, 95% CI 1.16-1.90, P 0.002). A positive identified BMI levels occurrence among psoriasis, significant difference observed highest (Q4) lowest (Q1) quartiles (P < 0.05). Further using fitting demonstrated consistent also evident patients. Age-stratified showed more prevalent older adults compared younger at same levels. For an inflection point noted men where its prevalence began decline exceeded certain threshold. Similarly, adults, decreased above specific Additionally, indicated played partial linking accounting approximately 22.91% association. may contribute relationship, indicating it could play two conditions.

Language: Английский

Citations

1
Psoriasis and Metabolic Disorders: A Comprehensive Meta-Analysis of Million Adults Worldwide DOI Open Access
Waleed Alajroush, Abdulelah I Alrshid, Ahmed H Alajlan

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 11, 2024

Psoriasis, a chronic inflammatory skin condition, and metabolic disorders, such as obesity, diabetes, dyslipidemia, have long been recognized distinct clinical entities. However, emerging evidence suggests complex bidirectional relationship between these seemingly unrelated conditions. Psoriasis is characterized by an accelerated cell turnover, resulting in the formation of erythematous plaques with silvery scales. Metabolic on other hand, encompass range conditions associated abnormal processes, including insulin resistance, low-grade inflammation. It intriguing to note that psoriasis commonly several comorbidities, higher prevalence observed individuals type 2 syndrome. Mounting inflammation plays pivotal role both disorders. Shared mediators, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), implicated pathogenesis Moreover, adipose tissue-derived hormones, known adipokines, leptin adiponectin, exert modulatory effects immune responses may contribute link abnormalities. Following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines, comprehensive search across databases identified 16 eligible studies (1975-2023), totaling 6,623,379 participants. Inclusion criteria encompassed peer-reviewed observational focusing adults specified outcomes. Data extraction, quality assessment (Newcastle-Ottawa scale (NOS)), meta-analyses, heterogeneity evaluations were conducted using rigorous methods. displayed significant association diabetes mellitus (DM, 18% increased incidence), hypertension (HTN, 35%), hyperlipidemia (19%), obesity (25%). Substantial was particularly DM. The NOS indicated varied study quality, some categorized high or moderate risk bias.

Language: Английский

Citations

8
Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome DOI
Yihui Chen, Cong Peng, Lei Zhu

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2024, Volume and Issue: 66(3), P. 294 - 315

Published: July 2, 2024

Language: Английский

Citations

4
Datura Metel L. Alleviates Psoriatic Symptoms and Regulates Lipid Metabolic Via Pparγ Activation: Network Pharmacology, Molecular Docking and Lipidomic Analysis DOI
M. Xu,

Xinlei Si,

Shi‐Zeng Lin

et al.

Published: Jan. 1, 2025

BackgroundPsoriasis is a chronic inflammatory and systemic disease with significant therapeutic challenges. Previous studies have indicated that Datura metel L. (DML) possesses anti-inflammatory properties other beneficial effects for psoriasis treatment, yet its regulatory mechanisms underlying these remain inadequately explored.ObjectiveThis study aimed to evaluate the efficacy of DML in psoriatic mouse model investigate through joint analyses.MethodsAn imiquimod (IMQ)- induced was established, administered via various routes determine optimal method. To address gap understanding action mechanism anti-psoriasis activity, comprehensive strategy employed, combining network pharmacology, molecular docking, lipidomic analysis, experimental validations.ResultDML observed significantly improve lesions, pathological manifestations markers associated psoriasis. Oral administration identified as appropriate route application. Network pharmacology predicted pharmacological targets may regulate response lipid metabolism by activating peroxisome proliferator-activated receptor (PPAR) γ. GW9662, PPARγ antagonist, diminished vivo validations analysis. Lipidomic analysis screened out 13 key metabolites DML's psoriasis.ConclusionDML effectively ameliorates IMQ-induced psoriasis-like skin lesions mice modulating inflammation metabolism, potentially PPARγ-dependent mechanism. This first demonstrate on metabolites, providing valuable insights clinical application treatment.

Language: Английский

Citations

0
Genetically predicted metabolites mediate the causal associations between immune cells and psoriasis DOI Creative Commons
Yuqian Luo

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 9, 2025

Language: Английский

Citations

0
Vesículas Extracelulares de Probióticos e Psoríase: Promessa Terapêutica ou Realidade? – Uma Revisão Integrativa DOI Creative Commons

Silvia Stanica,

Mariana Etchepare,

Marcia Regina Pincerati

et al.

Revista Sociedade Científica, Journal Year: 2025, Volume and Issue: 8(1), P. 434 - 452

Published: Feb. 3, 2025

A psoríase é uma doença inflamatória crônica que acomete 2-3% da população global , caracterizando-se por lesões cutâneas persistentes, desregulação imunológica, e significativa redução na qualidade de vida dos indivíduos afetados. Apesar avanços terapêuticos as opções disponíveis ,como tratamentos tópicos, sistêmicos biológicos enfrentam desafios relacionados à eficácia limitada, efeitos adversos altos custos, destacando a necessidade abordagens terapêuticas inovadoras. Nesse contexto, vesículas extracelulares derivadas probióticos (VEs ) têm emergido como estratégia promissora devido suas propriedades imunomoduladoras anti-inflamatórias. Os achados indicam VEs cepas Lactobacillus plantaram L.casei L.murinus Propionibacterium freudenreichii apresentam capacidade modular processos inflamatórios ao suprimir citocinas pró- inflamatórias (TNF-alfa IL-17) aumentar produção anti-inflamatórias (IL-10). Além disso promovem polarização do macrófagos para o fenótipo M2 favorecendo resolução inflamação regeneração tecidual modulam vias sinalização intracelular NF-kB contribuindo restauração homeostase tecidual.Esses mecanismos sugerem um relevante potencial terapêutico das no manejo doenças crônicas incluindo reforçam viabilidade seu uso em estratégias tópicas personalizadas.

Citations

0
The repurposing of Nitazoxanide for psoriasis treatment exerts therapeutic effects through skin metabolic reprogramming DOI
Jong Yeong Lee,

Ha Eun Kim,

Seung Taek Lee

et al.

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Potential Causal Relationship Between Extensive Lipid Profiles and Various Hair Loss Diseases: Evidence From Univariable and Multivariable Mendelian Randomization Analyses DOI Creative Commons

Yuhan Xie,

Ruimin Bai, Landong Ren

et al.

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(4)

Published: April 1, 2025

ABSTRACT Background Hair loss disorders, including non‐cicatricial forms such as alopecia areata (AA) and androgenetic (AGA), well cicatricial forms, represent significant dermatological concerns influenced by various factors, lipid metabolism. While observational studies clinical trials have suggested a link between levels hair loss, the causal relationship remains unclear. Methods We conducted comprehensive analysis of 983 variables [including triglycerides (TG), fatty acids, cholesterol, cholesterol esters, phospholipids, lipoproteins] 4 disorders. Two‐sample univariable Mendelian randomization (UVMR) multivariable (MVMR) analyses were employed to investigate effects lipids on Sensitivity performed ensure robustness our findings. Results The UVMR identified 56 associations with high‐density lipoprotein (HDL‐C), low‐density (LDL‐C), TG, apolipoprotein A1, B, lipoprotein(a) emerging key contributors. MVMR evaluated independent HDL‐C, LDL‐C, TG identifying only AA. confirmed consistency these results. Conclusion This study provides strong evidence for potential highlighting therapeutic targets importance management in affected patients.

Language: Английский

Citations

0
Severe Allergy as a Chronic Inflammatory Condition From a Systems Biology Perspective DOI Creative Commons
María Isabel Delgado Dolset, Carmela Pablo‐Torres, N. Contreras

et al.

Clinical & Experimental Allergy, Journal Year: 2024, Volume and Issue: 54(8), P. 550 - 584

Published: June 27, 2024

Persistent and unresolved inflammation is a common underlying factor observed in several seemingly unrelated human diseases, including cardiovascular neurodegenerative diseases. Particularly, atopic conditions, acute inflammatory responses such as those triggered by insect venom, food or drug allergies possess also life-threatening potential. However, respiratory predominantly exhibit late immune associated with chronic inflammation, that can eventually progress into severe phenotype displaying similar features other the case of uncontrolled asthma. This review aims to explore different facets systems involved allergic processes tissue remodelling cell dysregulation, well genetic, metabolic microbiota alterations, which are conditions. Our goal here was deepen on understanding an entangled disease expose potential avenues for development better diagnostic intervention strategies.

Language: Английский

Citations

1
Novel Fatty Acid Biomarkers in Psoriasis and the Role of Modifiable Factors: Results from the METHAP Clinical Study DOI Creative Commons
Evangelia Sarandi,

Sabine Krueger‐Krasagakis,

Dimitris Tsoukalas

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1114 - 1114

Published: Sept. 4, 2024

Psoriasis is a chronic, immune-mediated skin condition with significant metabolic complications. Although lipid metabolism linked to its pathogenesis, reliable biomarkers and the impact of modifiable factors remain underexplored. The aim present study was identify potential biomarkers, affected networks, assess role dietary lifestyle in psoriasis. Plasma samples from 56 patients psoriasis 49 healthy controls were analyzed, as part Metabolic Biomarkers Hashimoto's Thyroiditis (METHAP) clinical trial. Using Gas Chromatography-Mass Spectrometry 23 fatty acids their ratios quantified, revealing changes Specifically, lower levels α-linoleic acid (C18:3n3), linoleic (C18:2n6), gamma-linolenic (C18:3n6) observed along higher eicosatrienoic (C20:3n3), eicosapentaenoic (C20:5n3), erucic (C22:1n9). Total polyunsaturated (PUFA) significantly decreased, ratio saturated total (SFA/Total) increased (

Language: Английский

Citations

1