International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127352 - 127352
Published: Oct. 12, 2023
Language: Английский
Progress in Polymer Science, Journal Year: 2023, Volume and Issue: 141, P. 101677 - 101677
Published: April 22, 2023
Language: Английский
Citations
30
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(8), P. 2617 - 2642
Published: Jan. 1, 2023
Glycomacromolecules show significant potential as antimicrobials. We highlight recent studies on their performance in hindering host cell entry and biofilm formation, drug delivery diagnostic agents.
Language: Английский
Citations
29
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129901 - 129901
Published: Feb. 3, 2024
Language: Английский
Citations
14
Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(12)
Published: March 20, 2025
West Nile virus (WNV) and Usutu (USUV) are closely related mosquito-borne neurotropic flaviviruses that share common transmission cycle can infect humans. However, while human infections by WNV widespread, USUV comparatively less frequent, severe, currently limited to Africa Europe. To identify host factors contribute the pathogenic signatures of these two flaviviruses, we carried out an arrayed expression screen over 1,300 interferon-stimulated genes (ISGs). Several ISGs known target including IFI6, SHFL, RTP4 were among strongest hits. Interestingly, also found MITD1, ISG with no previously reported antiviral activity, We demonstrated activity MITD1 was not WNV, since it inhibited Zika dengue replication. interfere viral RNA replication sequestering specific endosomal sorting complexes required for transport-III (ESCRT-III) proteins involved in formation factories. increased type I interferon (IFN-I) most cells mouse tissues examined, although strongly IFN-I. Strikingly, induced brain USUV-infected mice importantly, monocyte-derived microglia. Using microglial-like cells, confirmed is essential mediator anti-flavivirus IFN-I cells. conclude plays a key role cellular defenses against flaviviruses.
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153513 - 153513
Published: June 25, 2024
Language: Английский
Citations
6
Macromolecules, Journal Year: 2023, Volume and Issue: 56(12), P. 4387 - 4430
Published: June 13, 2023
Anticoagulant macromolecules have gained widespread use in the clinical treatment of cardiovascular diseases, blood-contacting or implantable materials, and medical devices due to their excellent anticoagulant properties. Inspired by molecular characteristics physiological anticoagulants that play a vital role normal human coagulation anticoagulation mechanisms, diverse with special structures functional groups been developed, where they can be systematically applied biomedical field. In this Perspective, history recent progress synthetic methods for obtained purification natural products, semisynthetic methods, are discussed from aspect design. The critical application immense development potential these field biomedicine is proposed.
Language: Английский
Citations
16
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: March 23, 2023
Abstract Great interest exists towards the discovery and development of broad-spectrum antivirals. This occurs due to frequent emergence new viruses which can also eventually lead pandemics. A reasonable efficient strategy develop antivirals relies on targeting a common molecular player various viruses. Heparan sulfate is sulfated glycosaminoglycan present surface cells plays key role as co-receptor in many virus infections. In previous work, marine glycans (MSGs) were identified having antiviral activities. Their mechanism action primarily competitive inhibition virion binding heparan sulfate, preventing attachment cell prior entry. current work we used pseudotyped lentivirus particles investigate comparative fashion inhibitory properties five structurally defined MSGs against SARS-CoV-1, SARS-CoV-2, MERS-CoV, influenza (IAV). include disaccharide-repeating galactan from red alga Botryocladia occidentalis , tetrasaccharide-repeating fucans sea urchin Lytechinus variegatus cucumber Isostichopus badionotus two fucosylated chondroitin sulfates cucumbers I. Pentacta pygmaea . Results indicate specificity SARS-CoV-1 SARS-CoV-2. Curiously, showed decreased potencies MERS-CoV negligible IAV. Among MSGs, here studied deserve further attention since they have lowest anticoagulant effects but still potent selective properties.
Language: Английский
Citations
13
Marine Drugs, Journal Year: 2023, Volume and Issue: 21(5), P. 264 - 264
Published: April 25, 2023
Sulfated glycans from marine organisms are excellent sources of naturally occurring glycosaminoglycan (GAG) mimetics that demonstrate therapeutic activities, such as antiviral/microbial infection, anticoagulant, anticancer, and anti-inflammation activities. Many viruses use the heparan sulfate (HS) GAG on surface host cells co-receptors for attachment initiating cell entry. Therefore, virion-HS interactions have been targeted to develop broad-spectrum antiviral therapeutics. Here we report potential anti-monkeypox virus (MPXV) activities eight defined sulfated glycans, three fucosylated chondroitin sulfates, fucans extracted sea cucumber species
Language: Английский
Citations
12
Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown
Published: March 8, 2025
In this study, the first recyclable and reusable polystyrene solid support (resin with functional linker) for Fmoc-based phase synthesis (SPS) of sequence-defined oligoamides peptides is presented. By introducing an acid-labile cyclic acetal linker, efficient oligomer cleavage under mildly acidic conditions comparable to conventional linkers achieve while also enabling on-resin regeneration linker. This ability allows be reused multiple cycles without compromising flexibility, high reproducibility, structural control inherent solid-phase synthesis. As a proof concept, robustness approach demonstrated by synthesizing different dimeric structures in alternating manner on same resin. For each cycle, elongated through building block coupling, followed from release product. The linker then regenerated functionalized support, allowing cycle repeated subsequent oligomers. maintains yields purity across cycles, illustrating potential as versatile more sustainable methodology
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14
Published: June 27, 2023
The COVID-19 pandemic has rekindled interest in the molecular mechanisms involved early steps of infection cells by viruses. Compared to SARS-CoV-1 which only caused a relatively small albeit deadly outbreak, SARS-CoV-2 led fulminant spread and full-scale characterized efficient virus transmission worldwide within very short time. Moreover, mutations acquired over many months transmission, particularly those seen Omicron variant, have turned out result an even more transmissible virus. Here, we focus on events cells. We review evidence that first decisive step this process is electrostatic interaction spike protein with heparan sulfate chains present surface target cells: Patches cationic amino acids located can interact intimately negatively charged chains, results binding virion cell surface. In second step, specific receptor domain (RBD) angiotensin-converting enzyme 2 (ACE2) leads uptake bound virions into cell. show these be expressed as semi-quantitative model calculating potential different proteins using Adaptive Poison-Boltzmann-Solver (APBS). This software allows visualization positive patches, increased markedly from original Wuhan strain variant. thus enhanced much stronger variant compared wild-type At same time, data taken literature demonstrate RBD ACE2 remains constant limits error. Finally, briefly digress other viruses usefulness processes calculations for cell-virus interactions generally.
Language: Английский
Citations
9