Expert Opinion on Drug Delivery,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 29, 2025
Drug
administration
is
ubiquitous
in
the
healthcare
field,
and
it
crucial
to
optimize
drug
delivery
methods
improve
efficacy,
reduce
systemic
toxicity,
enhance
patient
compliance
Thermogels
have
shown
immense
potential
due
their
injectability,
biocompatibility,
ability
provide
localized
sustained
release.
This
paper
discusses
unique
properties
of
thermogel
relation
kinetics
suitability
as
a
carrier.
Different
considerations
applications
systems
(DDS)
were
highlighted
challenges
enter
market
discussed.
A
comprehensive
literature
search
was
conducted
using
major
databases
such
PubMed,
Scopus,
Web
Science.
The
employed
relevant
keywords
identify
studies
on
DDS.
Clinicaltrials.gov
also
utilized
determine
current
state
clinical
studies.
Nonetheless,
holds
great
promise
for
future
DDS
with
research
achieving
greater
heights
terms
complexity
pursuits.
Their
flexibility
fabrication
modularity
manner
makes
material
tailor
different
be
integrated
into
various
biomedical
disciplinaries.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Nov. 29, 2023
Abstract
Traditional
Chinese
Medicines
(TCMs)
have
been
used
for
centuries
the
treatment
and
management
of
various
diseases.
However,
their
effective
delivery
to
targeted
sites
may
be
a
major
challenge
due
poor
water
solubility,
low
bioavailability,
potential
toxicity.
Nanocarriers,
such
as
liposomes,
polymeric
nanoparticles,
inorganic
nanoparticles
organic/inorganic
nanohybrids
based
on
active
constituents
from
TCMs
extensively
studied
promising
strategy
improve
achieve
higher
therapeutic
effect
with
fewer
side
effects
compared
conventional
formulations.
This
review
summarizes
recent
advances
in
nanocarrier-based
systems
types
TCMs,
including
terpenoids,
polyphenols,
alkaloids,
flavonoids,
quinones,
different
natural
sources.
covers
design
preparation
nanocarriers,
characterization,
vitro/vivo
evaluations.
Additionally,
this
highlights
challenges
opportunities
field
suggests
future
directions
research.
Nanocarrier-based
shown
great
improving
efficacy
serve
comprehensive
resource
researchers
field.
Graphical
abstract
Pharmacological Research - Modern Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
10, P. 100386 - 100386
Published: Feb. 4, 2024
The
most
significant
obstacle
in
addressing
cancer
is
the
development
of
multidrug
resistance
during
chemotherapy.
Cancer
cells
have
ability
to
endure
numerous
cycles
traditional
chemotherapy
drugs
before
ultimately
developing
treatment.
Combining
a
strategy
used
address
problem
resistance.
Persistent
challenges
with
synthetic
include
catastrophic
adverse
reactions
and
other
consequences.
Natural
compounds
originating
from
Chinese
medicine
are
acknowledged
for
their
minimal
toxicity
possible
benefits
reversing
induced
by
mainstream
chemotherapeutic
or
targeted
treatments.
(MDR)
an
immediate
clinical
justification
unsatisfactory
recurrence
metastasis
precipitated
MDR,
leading
high
risk
death.
unique
nano-delivery
method
therapeutic
management
MDR
cancers
has
emerged
as
key
use
nanotechnology.
Because
its
anticancer
prospective,
(TCM)-combination
therapy
emerging
treatment
modality
essential
option
cancer.
By
precisely
regulating
release
medicines
delivering
pharmaceuticals
cancerous
cells,
nano
drug-delivery
devices
offer
amazing
pave
way
growth
TCM-combination
therapies.
present
review
examines
literature
on
three
important
topics:
mechanism
chemotherapy,
role
herbs
formulation
treatment,
incorporation
TCM
nanotechnology-based
drug
delivery
systems
circumvent
limitations
system.
Major
sources
work
PubMed,
Google
Scholar,
ResearchGate,
Embase,
ScienceDirect.
All
aspects
pertaining
TCM,
nanotechnology
more
than
50
years
were
considered,
emphasis
formulation,
various
forms
advances
system
result
nanotechnology,
everything
else
between.
As
becomes
closely
associated
realm
practice
broadening.
Furthermore,
it
enhances
prospects
future
research
facilitates
advancement
modern
Traditional
Medicine
(TCM).
integrating
into
meticulously
designed
system,
will
enhance
both
treat
prevent
diseases
even
greater
efficacy
previously.
This
article
nano-TCM
explores
characteristics,
compositions,
relevant
techniques
preparation
application
MDR.
In
addition,
comprehensive
elucidation
had
been
given
respect
objective
this
study
was
analyze
existing
body
(TCM)
that
can
be
encompasses
like
active
components
utilization
(MDR),
potential
advancements
obstacles
TCM-based
combinations.
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(1), P. 8 - 8
Published: Jan. 1, 2025
Each
year,
the
number
of
cases
strokes
and
deaths
due
to
this
is
increasing
around
world.
This
could
be
work
stress,
lifestyles,
unhealthy
food
habits,
several
other
reasons.
Currently,
there
are
traditional
methods
like
thrombolysis
mechanical
thrombectomy
for
managing
strokes.
The
current
approach
has
limitations,
delayed
diagnosis,
limited
therapeutic
delivery,
risks
secondary
injuries.
So,
a
need
some
effective
reliable
management
strokes,
which
help
in
early
diagnosis
followed
by
treatment
Nanotechnology
played
an
immense
role
recently,
it
emerged
as
transformative
solution
offering
innovative
diagnostic
tools
strategies.
Nanoparticles
(NPs)
belonging
classes,
including
metallic
(metallic
metal
oxide),
organic
(lipids,
liposome),
carbon,
can
cross
blood–brain
barrier
may
exhibit
potential
various
Moreover,
these
NPs
have
exhibited
promise
improving
imaging
specificity
delivery
precise
drug
real-time
monitoring
efficacy.
Nanomaterials
cerium
oxide
(CeO2)
liposome-encapsulated
agents
neuroprotective
properties
that
reduce
oxidative
stress
promote
neuroregeneration.
In
present
article,
authors
emphasized
significant
advancements
nanomedicine
stroke,
NPs-based
systems,
neuroregenerative
therapies,
multimodal
advancements.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(18), P. 8791 - 8806
Published: Jan. 1, 2024
This
review
explores
the
potential
of
integrating
nano-delivery
systems
with
traditional
Chinese
herbal
medicine,
acupuncture,
and
medical
theory.
It
highlights
intersections
in
enhancing
effectiveness
medicine
acupuncture
treatments.
In
addition,
it
discusses
how
integration
theory
can
modernize
make
more
readily
accessible
on
a
global
scale.
Finally,
analyzes
challenges
future
directions
this
field.
