ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(4), P. 3553 - 3574
Published: Jan. 16, 2024
Large
full-thickness
skin
lesions
have
been
one
of
the
most
challenging
clinical
problems
in
plastic
surgery
repair
and
reconstruction.
To
achieve
situ
regeneration
perfect
outcomes,
we
must
address
two
significant
obstacles:
angiogenesis
deficiency
inflammatory
dysfunction.
Recently,
black
phosphorus
has
shown
great
promise
wound
healing.
However,
few
studies
explored
bio-effects
BP
to
promote
based
on
its
nanoproperties.
Here,
investigate
whether
nanosheets
positive
repair,
verified
nanosheets'
effects
angiogenic
anti-inflammatory
abilities
vitro.
Next,
vivo
evaluation
performed
rat
large
excisional
splinting
model
more
comprehensively
showed
that
are
multilevel
healing,
which
can
effectively
enhance
ability,
angiogenesis,
collagen
deposition,
re-epithelialization.
Then,
multiomics
analysis
was
explore
further
mechanism
regulation
endothelial
cells
depth.
Molecular
mechanistically,
activated
JAK-STAT-OAS
signaling
pathway
cellular
function
mitochondrial
energy
metabolism
cells.
This
study
provide
a
theoretical
basis
for
applying
two-dimensional
as
nanomedicine
tissue
complex
human
pathological
microenvironments,
guiding
subsequent
optimization
phosphorus.
Proceedings of the National Academy of Sciences,
Journal Year:
2020,
Volume and Issue:
117(46), P. 28667 - 28677
Published: Nov. 2, 2020
The
treatment
of
diabetic
ulcer
(DU)
remains
a
major
clinical
challenge
due
to
the
complex
wound-healing
milieu
that
features
chronic
wounds,
impaired
angiogenesis,
persistent
pain,
bacterial
infection,
and
exacerbated
inflammation.
A
strategy
effectively
targets
all
these
issues
has
proven
elusive.
Herein,
we
use
smart
black
phosphorus
(BP)-based
gel
with
characteristics
rapid
formation
near-infrared
light
(NIR)
responsiveness
address
problems.
in
situ
sprayed
BP-based
could
act
as
1)
temporary,
biomimetic
"skin"
temporarily
shield
tissue
from
external
environment
accelerate
wound
healing
by
promoting
proliferation
endothelial
cells,
vascularization,
angiogenesis
2)
drug
"reservoir"
store
therapeutic
BP
pain-relieving
lidocaine
hydrochloride
(Lid).
Within
several
minutes
NIR
laser
irradiation,
generates
local
heat
microcirculatory
blood
flow,
mediate
release
loaded
Lid
for
"on-demand"
pain
relief,
eliminate
bacteria,
reduce
Therefore,
our
study
not
only
introduces
concept
sprayed,
NIR-responsive
relief
targeting
challenging
diabetes
but
also
provides
proof-of-concept
application
materials
DU
treatment.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: June 8, 2020
The
use
of
photothermal
agents
(PTAs)
in
cancer
therapy
(PTT)
has
shown
promising
results
clinical
studies.
rapid
degradation
PTAs
may
address
safety
concerns
but
usually
limits
the
stability
required
for
efficacious
treatment.
Conversely,
with
high
degrade
slowly.
solutions
that
balance
between
and
are
rare.
Here,
we
report
inherent
Cu2+-capturing
ability
black
phosphorus
(BP)
can
accelerate
BP,
while
also
enhancing
stability.
incorporation
Cu2+
into
BP@Cu
nanostructures
further
enables
chemodynamic
(CDT)-enhanced
PTT.
Moreover,
by
employing
64Cu2+,
positron
emission
tomography
(PET)
imaging
be
achieved
vivo
real-time
quantitative
tracking.
Therefore,
our
study
not
only
introduces
an
"ideal"
PTA
bypasses
limitations
PTAs,
provides
proof-of-concept
application
BP-based
materials
PET-guided,
CDT-enhanced
combination
therapy.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(12), P. 4996 - 5041
Published: Jan. 1, 2022
This
review
systematically
summarizes
the
research
status,
challenges,
prospects,
and
potential
bench-to-bedside
translation
of
minimally
invasive
nanomedicines.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Feb. 18, 2021
Abstract
Clay-based
nanomaterials,
especially
2:1
aluminosilicates
such
as
vermiculite,
biotite,
and
illite,
have
demonstrated
great
potential
in
various
fields.
However,
their
characteristic
sandwiched
structures
the
lack
of
effective
methods
to
exfoliate
two-dimensional
(2D)
functional
core
layers
(FCLs)
greatly
limit
future
applications.
Herein,
we
present
a
universal
wet-chemical
exfoliation
method
based
on
alkali
etching
that
can
intelligently
“capture”
ultrathin
biocompatible
FCLs
(MgO
Fe
2
O
3
)
between
two
identical
tetrahedral
(SiO
Al
from
vermiculite.
Without
sandwich
shielded
active
sites,
obtained
FCL
nanosheets
(NSs)
exhibit
tunable
appropriate
electron
band
structure
(with
bandgap
decreased
2.0
eV
1.4
eV),
conductive
increased
−0.4
−0.6
eV,
excellent
light
response
characteristics.
The
properties
2D
NSs
endow
them
with
exciting
diverse
applications
including
energy,
photocatalysis,
biomedical
engineering.
This
study
specifically
highlights
application
cancer
theranostics
an
example,
potentially
serving
prelude
extensive
studies
NSs.
Exploration,
Journal Year:
2021,
Volume and Issue:
1(2)
Published: Oct. 1, 2021
Bone
defects
pose
a
heavy
burden
on
patients,
orthopedic
surgeons,
and
public
health
resources.
Various
pathological
conditions
cause
bone
including
trauma,
tumors,
inflammation,
osteoporosis,
so
forth.
Auto-
allograft
transplantation
have
been
developed
as
the
most
commonly
used
clinic
treatment
methods,
among
which
autologous
grafts
are
golden
standard.
Yet
repair
of
defects,
especially
large-volume
in
geriatric
population
or
those
complicated
with
systemic
disease,
is
still
challenge
for
regenerative
medicine
from
clinical
perspective.
The
fast
development
biomaterials
nanomedicine
favors
emergence
promotion
efficient
regeneration
therapies.
In
this
review,
we
briefly
summarize
progress
novel
biomaterial
nanomedical
approaches
to
then
discuss
current
challenges
that
hinder
their
applications
treating
defects.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(32)
Published: June 10, 2021
Abstract
Non‐invasive
cancer
photothermal
therapy
(PTT)
is
a
promising
replacement
for
traditional
treatments.
The
second
near‐infrared
region
induced
PTT
(NIR‐II
PTT,
1000–1500
nm)
with
less
energy
dissipation
has
been
developed
deeper‐seated
tumor
treatment
in
recent
years
compared
the
first
light
(750–1000
nm).
In
addition,
use
of
emerging
inorganic
2D
nanomaterials
as
agents
(PTAs)
further
enhanced
efficiency
due
to
their
intrinsic
properties.
NIR‐II
stimulated
becoming
hot
topic
both
academic
and
clinical
fields.
This
review
summarizes
categories,
structures,
conversion
properties
time.
synergistic
strategies
responsive
combined
other
approaches
including
chemotherapy,
chemodynamic
therapy,
photodynamic
radiotherapy
are
summarized.
future
challenges
perspectives
on
these
systems
construction
discussed.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(20), P. 11381 - 11485
Published: Jan. 1, 2021
To
date,
nanotechnology
has
increasingly
been
identified
as
a
promising
and
efficient
means
to
address
number
of
challenges
associated
with
public
health.
In
the
past
decade,
two-dimensional
(2D)
biomaterials,
unique
nanoplatform
planar
topology,
have
attracted
explosive
interest
in
various
fields
such
biomedicine
due
their
morphology,
physicochemical
properties
biological
effect.
Motivated
by
progress
graphene
biomedicine,
dozens
types
ultrathin
2D
biomaterials
found
versatile
bio-applications,
including
biosensing,
biomedical
imaging,
delivery
therapeutic
agents,
cancer
theranostics,
tissue
engineering,
well
others.
The
effective
utilization
stems
from
in-depth
knowledge
structure-property-bioactivity-biosafety-application-performance
relationships.
A
comprehensive
summary
for
is
still
lacking.
this
review,
we
aim
concentrate
on
state-of-the-art
particular
focus
applications.
particular,
discuss
design,
fabrication
functionalization
used
diverse
applications
based
up-to-date
progress.
Furthermore,
interactions
between
systems
spatial-temporal
scale
are
highlighted,
which
will
deepen
understanding
underlying
action
mechanism
aiding
design
improved
functionalities.
Finally,
taking
bench-to-bedside
focus,
conclude
review
proposing
current
crucial
issues/challenges
presenting
future
development
directions
advance
clinical
translation
these
emerging
biomaterials.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Aug. 6, 2021
Abstract
The
modulation
of
intracellular
reactive
oxygen
species
(ROS)
levels
is
crucial
for
cellular
homeostasis
and
determination
fate.
A
sublethal
level
ROS
sustains
cell
proliferation,
differentiation
promotes
tumor
metastasis,
while
a
drastic
burst
directly
induces
apoptosis.
Herein,
surface-oxidized
arsenene
nanosheets
(As/As
x
O
y
NSs)
with
type
II
heterojunction
are
fabricated
efficient
·O
2
−
1
production
glutathione
consumption
through
prolonging
the
lifetime
photo-excited
electron-hole
pairs.
Moreover,
portion
As
vacancies
not
only
catalyzes
Fenton-like
reaction,
generating
·OH
from
H
,
but
also
inactivates
main
anti-oxidants
to
cut
off
“retreat
routes”
ROS.
After
polydopamine
(PDA)
cancer
membrane
(M)
coating,
engineered
As/As
@PDA@M
NSs
serve
as
an
intelligent
theranostic
platform
active
targeting
long-term
blood
circulation.
Given
its
narrow-band-gap-enabled
in
vivo
fluorescence
imaging
properties,
could
be
applied
imaging-guided
non-invasive
real-time
nanomedicine
therapy.
Bioactive Materials,
Journal Year:
2020,
Volume and Issue:
5(4), P. 1071 - 1086
Published: July 15, 2020
Smart
drug
delivery
nano-systems
show
significant
changes
in
their
physical
or
chemical
properties
response
to
slight
change
environmental
and/or
signals,
and
further
releasing
drugs
adjusted
the
progression
of
disease
at
right
target
rate
intelligently.
Two-dimensional
materials
possess
dramatic
status
extend
all
over
various
scientific
technological
disciplines
by
reason
exceptional
unique
application
smart
nano-systems.
In
this
review,
we
summarized
current
progress
highlight
kinds
two-dimensional
carriers
which
are
widely
explored
systems
as
well
classification
stimuli
responsive
advantages
disadvantages
applications.
Consequently,
anticipate
that
review
might
inspire
development
new
with
systems,
deepen
researchers'
understanding
nano-carries
based
on
materials.
