Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Nov. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
ACS Applied Nano Materials,
Journal Year:
2021,
Volume and Issue:
4(11), P. 11353 - 11385
Published: Nov. 16, 2021
Photothermal
therapy
(PTT)
is
recognized
as
a
promising
approach
for
cancer
theranostics
via
the
nonradiative
conversion
of
light
into
heat
energy.
PTT
treatment
able
to
reduce
adverse
side
effects
traditional
chemotherapy.
Some
nanomaterials
functionalized
with
unique
physical
and
chemical
properties
have
been
integrated
multiple
imaging
modalities
therapeutic
function
applications.
In
past
decade,
various
applications
reviewed,
but
comprehensive
survey
all
classes
photothermal
developed
in
recent
years
has
not
done.
A
discussion
mechanisms
using
different
their
application
combination
useful
providing
insights
material
development
disease
future.
this
review,
advancement
excellence
combined
therapies
field
anticancer
are
discussed.
The
momentous
property
tailored
advancing
noninvasive
also
highlighted.
Because
great
deal
decades
reviewed
years,
we
only
include
latest
results
reported
5
comparison.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(51)
Published: Sept. 4, 2023
Abstract
The
development
of
a
multi‐functional
solar‐driven
interfacial
evaporation
(SDIE)
system
remains
significant
challenge
for
its
large‐scale
applications.
By
taking
advantage
high
surface
area,
excellent
young's
moduli,
anchoring/coupling
capability,
large
absorption
surface,
strong
in
the
broadband
solar
spectrum,
and
efficient
photothermal
conversion
efficiencies
2D
emerging
materials
(Xenes,
Mxenes,
etc.),
hybrid
SDIEs
are
developed
to
increase
use
energy
beyond
water
production.
This
work
aims
offer
systematic
review
recent
advancement
except
graphene
their
role
stimulate
both
fundamental
applied
research
on
utilizing
underutilized
auxiliary
sources
future
integrated
water,
energy,
environmental
systems.
For
this
purpose,
first,
most
progress
is
discussed,
mainly
including
Xenes,
MXenes,
TMDs‐inspired
SDIEs.
Second,
structural
optimization
strategies
modulation
intrinsic
performances
highlighted.
Third,
cutting‐edge
conceptual
designs
many
applications
such
as
thermoelectricity,
salt
recovery,
hydrogen
production
broadly
presented.
Lastly,
current
challenges
perspectives
structures
also
mentioned.
Biomaterials Research,
Journal Year:
2022,
Volume and Issue:
26(1)
Published: Sept. 30, 2022
Near-infrared-II
(NIR-II,
1000-1700
nm)
light-triggered
photothermal
therapy
(PTT)
has
been
regarded
as
a
promising
candidate
for
cancer
treatment,
but
PTT
alone
often
fails
to
achieve
satisfactory
curative
outcomes.
Hollow
nanoplatforms
prove
be
attractive
in
the
biomedical
field
owing
merits
including
good
biocompatibility,
intrinsic
physical-chemical
nature
and
unique
hollow
structures,
etc.
On
one
hand,
themselves
can
NIR-II
agents
(PTAs),
cavities
of
which
are
able
carry
diverse
therapeutic
units
realize
multi-modal
therapies.
other
PTAs
capable
decorating
on
surface
combine
with
functions
components
encapsulated
inside
synergistic
treatment.
Notably,
generally
serve
photoacoustic
imaging
(PAI)
contrast
(CAs),
means
such
kind
also
expected
multifunctional
all-in-one
nanotheranostics.
In
this
review,
recent
advances
single-modal
PTT,
dual-modal
PTT/photodynamic
(PDT),
PTT/chemotherapy,
PTT/catalytic
PTT/gas
well
PTT/chemodynamic
(CDT)/chemotherapy,
PTT/chemo/gene
PTT/PDT/CDT/starvation
(ST)/immunotherapy
summarized
first
time.
Before
these,
typical
synthetic
strategies
structures
presented,
lastly,
potential
challenges
perspectives
related
these
novel
paradigms
future
research
clinical
translation
discussed.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(7), P. 11428 - 11443
Published: July 11, 2022
The
regulation
of
intracellular
ions'
overload
to
interrupt
normal
bioprocesses
and
cause
cell
death
has
been
developed
as
an
efficient
strategy
(named
ion-interference
therapy/IIT)
treat
cancer.
In
this
study,
we
design
a
multifunctional
nanoplatform
(called
BSArGO@ZIF-8
NSs)
by
in
situ
growth
metal
organic
framework
nanoparticles
(ZIF-8
NPs)
onto
the
graphene
oxide
(GO)
surface,
subsequently
reduced
ascorbic
acid
modified
bovine
serum
albumin.
This
nanocomplex
causes
Zn2+,
increase
reactive
oxygen
species
(ROS),
exerts
broad-spectrum
lethality
different
kinds
cancer
cells.
NSs
can
promote
apoptosis
initiating
bim
(a
pro-apoptotic
protein)-mediated
mitochondrial
apoptotic
events,
up-regulating
PUMA/NOXA
expression,
down-regulating
level
Bid/p53AIP1.
Meanwhile,
Zn2+
excess
triggers
cellular
dysfunction
mitochondria
damage
activating
autophagy
signaling
pathways
disturbing
environmental
homeostasis.
Combined
with
photothermal
effect
GO
(rGO),
mediated
combined
therapy
leads
effective
inhibits
proliferation
angiogenesis,
bringing
higher
efficacy
tumor
suppression
vivo.
designed
Zn-based
will
allow
promoting
further
development
IIT
corresponding
strategy.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(34)
Published: June 11, 2024
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
severe
trauma,
surgical
resection,
degenerative
disease,
congenital
malformation
pose
significant
clinical
challenges.
Bone
tissue
engineering
(BTE)
holds
immense
potential
in
treating
these
defects,
without
incurring
prevalent
complications
associated
with
conventional
autologous
or
allogeneic
grafts.
3D
printing
technology
enables
control
over
architectural
structures
at
multiple
length
scales
has
been
extensively
employed
to
process
biomimetic
scaffolds
for
BTE.
In
contrast
inert
grafts,
next-generation
smart
possess
a
remarkable
ability
mimic
the
dynamic
nature
native
extracellular
matrix
(ECM),
thereby
facilitating
regeneration.
Additionally,
they
can
generate
tailored
controllable
therapeutic
effects,
such
as
antibacterial
antitumor
properties,
response
exogenous
and/or
endogenous
stimuli.
This
review
provides
comprehensive
assessment
progress
3D-printed
BTE
applications.
It
begins
an
introduction
physiology,
followed
by
overview
technologies
utilized
scaffolds.
Notable
advances
various
stimuli-responsive
strategies,
efficacy,
applications
are
discussed.
Finally,
highlights
existing
challenges
development
implementation
scaffolds,
well
emerging
this
field.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(20)
Published: March 17, 2023
Integrating
the
ultralong
excitation
wavelength,
high
extinction
coefficient,
and
prominent
photothermal
conversion
ability
into
a
single
agent
is
an
appealing
yet
significantly
challenging
task.
Herein,
precise
dual-acceptor
engineering
strategy
exploited
for
this
attempt
based
on
donor-acceptor
(D-A)
type
semiconductor
polymers
by
subtly
regulating
molar
proportions
of
two
employed
electron
acceptor
moieties
featuring
different
electronic
affinity
π-conjugation
degrees,
making
full
use
active
intramolecular
motion-induced
effect.
The
optimal
polymer
SP4
synchronously
shows
desirable
second
near-infrared
(NIR-II)
absorption,
extremely
satisfactory
behavior.
Consequently,
unprecedented
performance
NPs
1064
nm
laser-excited
photoacoustic
imaging
(PAI)-guided
therapy
(PTT)
demonstrated
tumor
diagnosis
complete
elimination.
