Nile red‐based AIEgen for highly fluorescent polymer particles and its application in light‐scattering fluorescent films DOI Creative Commons

Hongkun Jiang,

Shengjie Chen,

Weizhipeng Wu

et al.

Smart Molecules, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Abstract Organic luminophores with superior solid‐state luminescence are urgently required in various fields, such as lighting, display, sensing, and solar energy conversion. However, to achieve their highly efficient still remains a challenge. Herein, newly designed Nile red derivative, Nile‐DPA‐VB, is successfully obtained exhibit aggregation‐induced emission characteristics the photoluminescent quantum yield (PLQY) of 11.45%. Such PLQY could be further promoted 53.45% when Nile‐DPA‐VB polymerized undergoing precipitation polymerization process, where confined aggregation microenvironment severely restricts intramolecular motions Nile‐DPA‐VB. Remarkably, ultrasensitive polarity steric effect, enabling real‐time monitoring evolution for polymerization. The microphase separation dynamic hardening nucleation growth processes visually demonstrated, which contribute dominantly high‐efficiency luminescence. Finally, by doping as‐prepared fluorescent polymeric particles into polymethyl methacrylate, functional films high haze achieved show potential lighting. These findings clearly demonstrate significant role constructing luminescent materials practice.

Language: Английский

Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs DOI
Lizhen Xu, Qian Zhang, Xin Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

Citations

20
The Current Status and Future Directions on Nanoparticles for Tumor Molecular Imaging DOI Creative Commons
Caiyun Yin,

Peiyun Hu,

Lijing Qin

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 9549 - 9574

Published: Sept. 1, 2024

Molecular imaging is an advanced technology that utilizes specific probes or markers in conjunction with cutting-edge techniques to observe and analyze the localization, distribution, activity, interactions of biomolecules within living organisms. Tumor molecular imaging, by enabling visualization quantification characteristics tumor cells, facilitates a deeper more comprehensive understanding tumors, providing valuable insights for early diagnosis, treatment monitoring, cancer biology research. However, image quality still requires improvement, nanotechnology has significantly propelled advancement imaging. Currently, nanoparticle-based technologies encompass radionuclide fluorescence magnetic resonance ultrasound photoacoustic multimodal among others. As our microenvironment deepens, design nanoparticle also evolved, offering new perspectives expanding applications Beyond diagnostics, there marked trend towards integrated diagnosis therapy, image-guided playing pivotal role. This includes surgery, photodynamic chemodynamic therapy. Despite continuous advancements innovative developments many these remain experimental stage require breakthroughs before they can be fully into clinical practice.

Language: Английский

Citations

8
Macrocyclic Peptide-Based Dual-Sensor Platform for Linkage-Specific Visualization of Ubiquitin Chain Assembling in Live Cells DOI
Han Gao,

Zhirong He,

Jian Chen

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Intracellular monitoring of protein ubiquitination and differentiating polyubiquitin chain topology are crucial for understanding life processes drug discovery, which is challenged by the high complexity process a lack molecular tools. Herein, synthetic dual-sensor platform specific K48-linked ubiquitin oligomers was tailored in situ visualization assembling live biosystems. This achieved using macrocyclic peptides as recognition motifs tetraphenylethylene derivative an activatable reporter. The efficient cell penetration, tight binding, protection delivered "freeze-and-image" approach, allowing fluorescent readout linkage type elongation without perturbing physiological environment. Motivated these unique features, mapping K48-ubiquitination dynamics during degradation facilely achieved. Rapid, sensitive, intracellular assessment mechanism action potency dependence proteolysis-targeting chimeras (PROTACs) demonstrated, presenting sensors promising tools PROTAC development.

Language: Английский

Citations

1
Rational Design of NIR‐II Emitting Conjugated Polymer Derived Nanoparticles for Image‐Guided Cancer Interventions DOI
Nikita Gill, Indrajit Srivastava, Joshua Tropp

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Due to the reduced absorption, light scattering, and tissue autofluorescence in NIR-II (1000-1700 nm) region, significant efforts are underway explore diverse material platforms for vivo fluorescence imaging, particularly cancer diagnostics image-guided interventions. Of reported imaging agents, nanoparticles derived from conjugated polymers (CPNs) offer unique advantages alternative materials including biocompatibility, remarkable absorption cross-sections, exceptional photostability, tunable emission behavior independent of cell labeling functionalities. Herein, current state emitting CPNs summarized structure-function-property relationships highlighted that can be used elevate performance next-generation CPNs. Methods particle processing incorporating targeting modalities discussed, as well detailed characterization methods improve interlaboratory comparisons novel materials. Contemporary specifically apply therapies then highlighted. This review not only summarizes field, but offers future directions provides clarity over other classes agents.

Language: Английский

Citations

5
Fully Inter-restricted Assembly of Aggregation-Induced Emission Luminogens and Polymers Enables Ultra-bright Nanoparticles for Sensitive Point-of-Care Diagnosis DOI
Xirui Chen, Qi Liu, Jiangjiang Zhang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Fluorescent lateral flow immunoassay (LFIA) is recognized as a leading quantitative point-of-care (POC) platform for precise clinical diagnostics. However, conventional fluorescent nanoprobes are hampered by low quantum yield (QY), which constrain the sensitivity of LFIA. Herein, we employed butterfly aggregation-induced emission luminogen (AIEgen) and developed fully inter-restricted assembly with polyphenyl polymer poly(maleicanhydride-styrene) (PMPS) to create highly homogeneous nanoparticles (ho-AIENPs) QY over 91%. Compared core-shell heterostructure (he-AIENPs), ho-AIENPs demonstrate structure AIEgens uniformly dispersed in PMPS matrix nanoparticles. The robust broad intermolecular interaction (e.g., π-π interactions) between effectively restricts molecular motion AIEgens, producing 30% increase than he-AIENPs. Ho-AIENPs exhibit 5-fold 80-fold improved compared traditional he-AIENP-based LFIAs AuNP-based colorimetric LFIAs. Owing excellent optical properties ho-AIENPs, ho-AIENP-based multiplex LFIAs, can simultaneously detect lung cancer biomarkers exceptionally high sensitivity. In contrast physical encapsulation strategies, strategy promising, versatile, efficient enhancing matrix-derived particles sensitizing immunoassays.

Language: Английский

Citations

0
Self-Assembly versus Coassembly: An Amphiphilic NIR-II Aggregation-Induced Emission Luminogen for Phototheranostics of Orthotopic Glioblastoma DOI
Yan Sun,

Xueke Yan,

Dong Wang

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Glioblastoma (GBM) is the most lethal form of malignant brain tumor, known for its high infiltration, aggressiveness, and poor prognosis. Second near-infrared (NIR-II, 1000-1700 nm) phototheranostic agents bring intriguing opportunities GBM management owing to their noninvasive nature, controllability, deeper tissue penetration. Herein, an amphiphilic NIR-II luminogen (PEG-TD) with aggregation-induced emission (AIE) characteristics, along hydrophobic counterpart (C6-TD), was meticulously synthesized. Specifically, PEG-TD nanoparticles (NPs), formed through straightforward self-assembly, exhibited superior stability, simplicity, robust reactive oxygen species production efficiency, excellent photothermal conversion compared C6-TD NPs, which were fabricated via coassembly DSPE-mPEG, primarily attributed distinct molecular arrangements within forming aggregates. The inherent advantages NPs led significant therapeutic efficacy against GL261 cells under 808 nm laser irradiation. Eventually, fluorescence/photothermal duplex imaging-guided combined photodynamic/photothermal therapy successfully performed in orthotopic glioblastoma mouse model minimal adverse effects.

Language: Английский

Citations

0
Biomimetic NIR-II fluorescent probe from covalent encapsulation enables high-performance NIR-II bioimaging DOI

Zijian Jiang,

Yijing Du,

Zetao Dang

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111351 - 111351

Published: May 1, 2025

Language: Английский

Citations

0
Carbazole Engineering in D–A–D Molecules to Improve the NIR-II Performance for Tumor Micrometastasis Imaging DOI
Le Fang,

Rui Ai,

María Eugenia Sandoval‐Salinas

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: June 2, 2025

It is important to image tumor micrometastases in fluorescence-guided surgery (FGS), which requires highly emissive materials with a high signal-to-background ratio. As one type of bright NIR-II dye, donor-acceptor-donor (D-A-D) molecules have been widely applied for vivo imaging. However, the brightness D-A-D when encapsulated nanoparticles bioimaging often unsatisfactory due aggregation-caused quenching or decrease absorption. In this study, we introduced carbazole groups molecules, resulted reduction fluorescence aggregated state larger intermolecular distance. Through proper engineering groups, emission spectra could be red-shifted peak beyond 1000 nm, while maintaining strong absorption and quantum yield. The brightest TBTC-4 were successfully micrometastasis imaging mice, metastases as small 0.5 mm diameter, demonstrates their promising clinical application FGS.

Language: Английский

Citations

0
Alkyl‐Doping Enables Significant Suppression of Conformational Relaxation and Intermolecular Nonradiative Decay for Improved Near‐Infrared Fluorescence Imaging DOI
Yuying Liang,

Yonghui Pan,

Lu Chen

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(36)

Published: June 20, 2024

Despite various efforts to optimize the near-infrared (NIR) performance of perylene diimide (PDI) derivatives for bio-imaging, convenient and efficient strategies amplify fluorescence PDI in biological environment intrinsic mechanism studies are still lacking. Herein, we propose an alkyl-doping strategy derivative-based nanoparticles improved NIR imaging. The developed derivative, OPE-PDI, shows much brighter n-Hexane (HE) compared with that other organic media, excited state dynamics investigation experimentally elucidates solvent effect-induced suppression intermolecular energy transfer intramolecular nonradiative decay as underlying improvement. Theoretical calculations reveal lowest reorganization energies OPE-PDI HE among solvents, indicating effectively suppressed conformational relaxation support strongest radiative decay. Inspired by this, alkyl atmosphere mimicking is constructed incorporating octadecane into OPE-PDI-based nanoparticles, permitting up 3-fold improvement counterpart nanoparticles. Owing merits high brightness, anti-photobleaching, low biotoxicity optimal they have been employed probing long-term monitoring tumor. This work highlights a facile enhancement

Language: Английский

Citations

2
Site-Specific Cascade-Activatable Fluorogenic Nanomicelles Enable Precision and Accuracy Imaging of Pulmonary Metastatic Tumor DOI Creative Commons
Xueqian Chen,

Jiatian Liu,

Yong Zhang

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(7), P. 2606 - 2616

Published: June 24, 2024

The precise localization of metastatic tumors with subtle growth is crucial for timely intervention and improvement tumor prognosis but remains a paramount challenging. To date, site-specific activation fluorogenic probes single-stimulus-based diagnosis typically targets an occult molecular event in complex biosystem limited specificity. Herein, we propose highly specific cascade-activated strategy to enhance detection accuracy, aiming achieve the accurate breast cancer (BC) lung metastasis cascade manner. Specifically, cascade-activatable NIR nanomicelles

Language: Английский

Citations

1