Synthesis of heavy-atom-free thienoisoindigo dye as near-infrared photosensitizer for type I photodynamic therapy and photoacoustic imaging DOI
Feng Zhang, Hao Cai, Leichen Wang

et al.

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 261, P. 113052 - 113052

Published: Nov. 5, 2024

Language: Английский

Simultaneous Reversal of T Lymphocytes and Cancer Cells Metabolism Via a Biomimetic Heavy‐Atom‐Free Photosensitizers‐Based Combination Therapies to Boost Cancer Photoimmunotherapy DOI Creative Commons
Yongjian Zhang, Xiaohong Wu, Kaiyuan Wang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: 12(16)

Published: March 5, 2025

Near-infrared (NIR) activated photosensitizers based on heavy-atom-free have great advantages in photoimmunotherapy, yet the tumor microenvironment often restricts their efficacy. To address this, a NIR-activated photosensitizer (named Cy-BF) is developed. Cy-BF then encapsulated with phospholipids and platelet exosome vesicles to create exosomes biomimetic loaded hybrid liposomes CHL) Characterized by high phototoxicity, low dark toxicity, enhanced targeting, CHL demonstrates aggregation-induced broadening of absorption spectra NIR (760 nm laser) activates photothermal therapy type I photodynamic therapy. The CHL-mediated phototherapy induces mitochondrial damage immunogenic cell death cells, decreases lactate production, alters reducing regulatory T cells increasing CD8+ cells. mitigate inhibition excess lactate, combination introduced using lithium carbonate, which repurposes as an energy source for thereby enhancing effectiveness photoimmunotherapy. This approach represents novel strategy reversing metabolism both paving way future clinical applications

Language: Английский

Citations

1
Molecular endoperoxides for optical imaging and photodynamic therapy DOI
Dapeng Chen, Tian Zhang,

Aihong Jiao

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216258 - 216258

Published: Oct. 4, 2024

Language: Английский

Citations

9
BODIPY based nanomedicine for cancer imaging and phototherapy DOI Creative Commons
Dapeng Chen, Tian Zhang, Xiaochen Dong

et al.

Colloids and Interface Science Communications, Journal Year: 2024, Volume and Issue: 64, P. 100816 - 100816

Published: Dec. 28, 2024

Language: Английский

Citations

3
Subcellular organelle targeted tumor phototherapy DOI
Man Lu,

Mingjing Huang,

Jing Chen

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216635 - 216635

Published: March 26, 2025

Language: Английский

Citations

0
Reversible gating of singlet fission by tuning the role of a charge-transfer state DOI Creative Commons
Yifan Bo, Yuxuan Hou,

Dominic A. X. Lavergne

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 26, 2025

Abstract Stimulus-responsive triplet excited states and multiexcitonic logic gates have garnered increasing interest. Singlet fission is an efficient multiple exciton generation process, in which one singlet converts into two triplets. is, however, rarely reported to be switchable by external stimuli. Here we design a meta -diethynylphenylene-linked tetracene dimer featuring pyridyl endgroups that function as acid/base-responsive switch, enabling the reversible modulation of fission. In its neutral form, interchromophore charge-transfer state facilitates promotes formation correlated triplet-pair state. Upon treatment with acid, protonation nitrogens generates more strongly electron-accepting pyridinium, leading intra-chromophore state, inhibits Finally, IMPLICATION gate constructed using acid base inputs monitoring based on

Language: Английский

Citations

0
Type I BODITh Photosensitizers with Twisted Conformation for Augmented Photodynamic Therapy and FOXO1-Involved Apoptosis DOI
Tian Zhang, Jiahong Li, Jinjun Shao

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Developing targeted type I photosensitizers with low oxygen-dependence is essential to overcome tumor hypoxia and address the short diffusion radius of free radicals in photodynamic therapy (PDT). Herein, two Boron dithiazolemethene (BODITh)-derivatives, SBDP-1 SBDP-2 different numbers thiophene units, were designed as mitochondria-targeted significant ·OH generation. Through theoretical calculations, additional unit induced a torsional conformation smaller overlap integral holes electrons than SBDP-1, resulting an increased spin-orbit coupling (SOC) constant decreased singlet-triplet energy gap (ΔEST), thereby promoting intersystem crossing (ISC) process. Moreover, through molecular docking study, NPs could bind miR-96 via hydrophobic interaction trigger forkhead box protein O1 (FOXO1) involved pathway accelerate cell apoptosis. This work presented innovative twisted for efficient cancer PDT conquer hypoxia.

Language: Английский

Citations

0
Red Blood Cell Membrane‐Camouflaged Red Phosphorus‐Modified C3N4 for Enhanced Tumoral Photodynamic Therapy DOI Creative Commons
Jiaxiu Liu,

Jingying Chen,

Tianyang Li

et al.

Advanced Materials Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Abstract The clinical application of photodynamic therapy (PDT) faces limitations due to the poor tumor‐targeting efficiency and systemic toxicity conventional photosensitizers. To overcome these challenges, a biomimetic nanoplatform (C3N4‐RP@RBCm) is developed by covalently coupling graphitic carbon nitride (C3N4) with red phosphorus nanoparticles, followed encapsulation erythrocyte membranes. This design utilizes CD47‐mediated immune evasion achieves tumor‐specific accumulation through enhanced permeability retention (EPR) effects. C3N4‐RP@RBCm demonstrates outstanding antitumor activity. Specifically, 24‐h exposure 20 µg mL −1 sufficient saturate HeLa cells. Upon 660 nm laser irradiation, controlled reactive oxygen species (ROS) are generated, resulting in apoptosis 89% cells, thereby efficiently enhancing anti‐tumor In tumor‐bearing mice, laser‐activated induces tumor cells more effectively inhibits xenografts. Moreover, at concentration 100 , percentage live remains above 99%, treatment less than 1.2% hemolysis human erythrocytes, indicating excellent biocompatibility. Consequently, causes minimal histopathological injuries heart, liver, spleen, lung, kidney tissues. Thus, this photosensitizer significant potential for application.

Language: Английский

Citations

0
Coassembly of Dual-Modulated AIE-ESIPT Photosensitizers and UCNPs for Enhanced NIR-Excited Photodynamic Therapy DOI
Zhen Hu, Jialin Li, Lili Feng

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Aggregation-induced emission (AIE) photosensitizers are promising for photodynamic therapy, yet their short excitation wavelengths present a limitation. In this study, we develop series of organic with dual modulation capabilities based on excited-state intramolecular proton transfer (ESIPT) and AIE. Notably, synthesize near-infrared (NIR)-excited photosensitive nanoparticles through coassembly strategy utilizing upconversion (UCNPs) amphiphilic polymers. The spectroscopic analysis theoretical calculations elucidate the significant impact additional or π-spacer groups conformational change energy barrier ESIPT process. An efficient Förster resonance between photosensitizer UCNPs is achieved strategy. Both

Language: Английский

Citations

2
Squaraine-based NIR dyes for phototheranostics DOI

Anqing Mei,

Xiaoyu He,

D.-P. R.-X. Lei

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 527, P. 216419 - 216419

Published: Dec. 28, 2024

Language: Английский

Citations

2
Synthesis of heavy-atom-free thienoisoindigo dye as near-infrared photosensitizer for type I photodynamic therapy and photoacoustic imaging DOI
Feng Zhang, Hao Cai, Leichen Wang

et al.

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 261, P. 113052 - 113052

Published: Nov. 5, 2024

Language: Английский

Citations

0