Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 261, P. 113052 - 113052
Published: Nov. 5, 2024
Language: Английский
Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 261, P. 113052 - 113052
Published: Nov. 5, 2024
Language: Английский
Advanced Science, Journal Year: 2025, Volume and Issue: 12(16)
Published: March 5, 2025
Near-infrared (NIR) activated photosensitizers based on heavy-atom-free have great advantages in photoimmunotherapy, yet the tumor microenvironment often restricts their efficacy. To address this, a NIR-activated photosensitizer (named Cy-BF) is developed. Cy-BF then encapsulated with phospholipids and platelet exosome vesicles to create exosomes biomimetic loaded hybrid liposomes CHL) Characterized by high phototoxicity, low dark toxicity, enhanced targeting, CHL demonstrates aggregation-induced broadening of absorption spectra NIR (760 nm laser) activates photothermal therapy type I photodynamic therapy. The CHL-mediated phototherapy induces mitochondrial damage immunogenic cell death cells, decreases lactate production, alters reducing regulatory T cells increasing CD8+ cells. mitigate inhibition excess lactate, combination introduced using lithium carbonate, which repurposes as an energy source for thereby enhancing effectiveness photoimmunotherapy. This approach represents novel strategy reversing metabolism both paving way future clinical applications
Language: Английский
Citations
1Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216258 - 216258
Published: Oct. 4, 2024
Language: Английский
Citations
9Colloids and Interface Science Communications, Journal Year: 2024, Volume and Issue: 64, P. 100816 - 100816
Published: Dec. 28, 2024
Language: Английский
Citations
3Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216635 - 216635
Published: March 26, 2025
Language: Английский
Citations
0Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 26, 2025
Abstract Stimulus-responsive triplet excited states and multiexcitonic logic gates have garnered increasing interest. Singlet fission is an efficient multiple exciton generation process, in which one singlet converts into two triplets. is, however, rarely reported to be switchable by external stimuli. Here we design a meta -diethynylphenylene-linked tetracene dimer featuring pyridyl endgroups that function as acid/base-responsive switch, enabling the reversible modulation of fission. In its neutral form, interchromophore charge-transfer state facilitates promotes formation correlated triplet-pair state. Upon treatment with acid, protonation nitrogens generates more strongly electron-accepting pyridinium, leading intra-chromophore state, inhibits Finally, IMPLICATION gate constructed using acid base inputs monitoring based on
Language: Английский
Citations
0Nano Letters, Journal Year: 2025, Volume and Issue: unknown
Published: May 12, 2025
Developing targeted type I photosensitizers with low oxygen-dependence is essential to overcome tumor hypoxia and address the short diffusion radius of free radicals in photodynamic therapy (PDT). Herein, two Boron dithiazolemethene (BODITh)-derivatives, SBDP-1 SBDP-2 different numbers thiophene units, were designed as mitochondria-targeted significant ·OH generation. Through theoretical calculations, additional unit induced a torsional conformation smaller overlap integral holes electrons than SBDP-1, resulting an increased spin-orbit coupling (SOC) constant decreased singlet-triplet energy gap (ΔEST), thereby promoting intersystem crossing (ISC) process. Moreover, through molecular docking study, NPs could bind miR-96 via hydrophobic interaction trigger forkhead box protein O1 (FOXO1) involved pathway accelerate cell apoptosis. This work presented innovative twisted for efficient cancer PDT conquer hypoxia.
Language: Английский
Citations
0Advanced Materials Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: May 22, 2025
Abstract The clinical application of photodynamic therapy (PDT) faces limitations due to the poor tumor‐targeting efficiency and systemic toxicity conventional photosensitizers. To overcome these challenges, a biomimetic nanoplatform (C3N4‐RP@RBCm) is developed by covalently coupling graphitic carbon nitride (C3N4) with red phosphorus nanoparticles, followed encapsulation erythrocyte membranes. This design utilizes CD47‐mediated immune evasion achieves tumor‐specific accumulation through enhanced permeability retention (EPR) effects. C3N4‐RP@RBCm demonstrates outstanding antitumor activity. Specifically, 24‐h exposure 20 µg mL −1 sufficient saturate HeLa cells. Upon 660 nm laser irradiation, controlled reactive oxygen species (ROS) are generated, resulting in apoptosis 89% cells, thereby efficiently enhancing anti‐tumor In tumor‐bearing mice, laser‐activated induces tumor cells more effectively inhibits xenografts. Moreover, at concentration 100 , percentage live remains above 99%, treatment less than 1.2% hemolysis human erythrocytes, indicating excellent biocompatibility. Consequently, causes minimal histopathological injuries heart, liver, spleen, lung, kidney tissues. Thus, this photosensitizer significant potential for application.
Language: Английский
Citations
0Nano Letters, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 11, 2024
Aggregation-induced emission (AIE) photosensitizers are promising for photodynamic therapy, yet their short excitation wavelengths present a limitation. In this study, we develop series of organic with dual modulation capabilities based on excited-state intramolecular proton transfer (ESIPT) and AIE. Notably, synthesize near-infrared (NIR)-excited photosensitive nanoparticles through coassembly strategy utilizing upconversion (UCNPs) amphiphilic polymers. The spectroscopic analysis theoretical calculations elucidate the significant impact additional or π-spacer groups conformational change energy barrier ESIPT process. An efficient Förster resonance between photosensitizer UCNPs is achieved strategy. Both
Language: Английский
Citations
2Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 527, P. 216419 - 216419
Published: Dec. 28, 2024
Language: Английский
Citations
2Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 261, P. 113052 - 113052
Published: Nov. 5, 2024
Language: Английский
Citations
0