Second Near‐Infrared Photothermal Semiconducting Polymer Nanoadjuvant for Enhanced Cancer Immunotherapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 16, 2020

Abstract Immunotherapy has offered new treatment options for cancer; however, the therapeutic benefits are often modest and desired to be improved. A semiconducting polymer nanoadjuvant (SPN II R) with a photothermally triggered cargo release second near‐infrared (NIR‐II) photothermal immunotherapy is reported here. SPN R consists of nanoparticle core as an NIR‐II converter, which doped toll‐like receptor (TLR) agonist adjuvant coated thermally responsive lipid shell. Upon photoirradiation, effectively generates heat not only ablate tumors induce immunogenic cell death (ICD), but also melt layers on‐demand TLR agonist. The combination ICD activation TLR7/TLR8 enhances maturation dendritic cells, amplifies anti‐tumor immune responses. Thus, single R‐mediated inhibits growth both primary distant eliminates lung metastasis in murine mouse model. This study thus provides remote‐controlled smart delivery system synergize photomedicine enhanced cancer treatment.

Language: Английский

---

Semiconducting Polycomplex Nanoparticles for Photothermal Ferrotherapy of Cancer

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(26), P. 10633 - 10638

Published: March 24, 2020

Abstract This study reports the development of iron‐chelated semiconducting polycomplex nanoparticles (SPFeN) for photoacoustic (PA) imaging‐guided photothermal ferrotherapy cancer. The hybrid polymeric nanoagent comprises a ferroptosis initiator (Fe 3+ ) and an amphiphilic (SP C serving as both nanotransducer iron ion chelator. By virtue poly(ethylene glycol) (PEG) grafting its small size, SPFeN accumulates in tumor living mice after systemic administration, which can be monitored by PA imaging. In acidic microenvironment, generates hydroxyl radicals, leading to ferroptosis; meanwhile, under NIR laser irradiation, it localized heat not only accelerate Fenton reaction but also implement therapy. Such combined ferrotherapeutic effect leads minimized dosage compared previous studies effectively inhibits growth mice, is possible controls.

Language: Английский

---

Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy

Nano Today, Journal Year: 2021, Volume and Issue: 37, P. 101073 - 101073

Published: Jan. 10, 2021

Language: Английский

---

The Chemistry of Organic Contrast Agents in the NIR‐II Window

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(14)

Published: Dec. 7, 2021

Abstract Optical imaging, especially fluorescence and photoacoustic is a non‐invasive imaging approach with high spatial temporal resolution sensitivity, compared to positron emission tomography (PET) or magnetic resonance (MRI). Due the merits of using second near‐infrared (NIR‐II) window, like deeper penetration depth, signal‐to‐noise ratio, resolution, low tissue damage, researchers have devoted great effort developing contrast agents NIR‐II absorption emission. In this Review, we summarize recently developed organic luminescent materials, ranging from small molecules conjugated polymers. Then, systematically introduce engineering strategies describe performance classified by skeleton cores. Finally, elucidate challenges prospects these dyes for potential clinical applications. We expect our summary can inspire expand spectrum diverse bioapplications.

Language: Английский

---

Photoactivatable Protherapeutic Nanomedicine for Cancer

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(34)

Published: July 15, 2020

Therapeutic systems with site-specific pharmaceutical activation hold great promise to enhance therapeutic efficacy while reducing systemic toxicity in cancer therapy. With operational flexibility, noninvasiveness, and high spatiotemporal resolution, photoactivatable nanomedicines have drawn growing attention. Distinct from traditional controlled release relying on the difference of biomarker concentrations between disease healthy tissues, capitalize interaction nanotransducers light either trigger photochemical reactions or generate reactive oxygen species (ROS) heat effect remotely induce actions living subjects. Herein, recent advances development protherapeutic nanoagents for oncology are summarized. The design strategies applications these described. Representative examples each type discussed terms structure, photoactivation mechanism, preclinical models. Last, potential challenges perspectives further develop nanomedicine discussed.

Language: Английский

---

Photoacoustic Imaging and Photothermal Therapy of Semiconducting Polymer Nanoparticles: Signal Amplification and Second Near‐Infrared Construction

Small, Journal Year: 2021, Volume and Issue: 17(6)

Published: Jan. 15, 2021

Photoacoustic (PA) imaging and photothermal therapy (PTT) have attracted extensive attention in disease diagnosis treatment. Although many exogenous contrast agents been developed for PA PTT, the design guidelines to amplify their performances remain challenging are highly demanded. Semiconducting polymer nanoparticles (SPNs) composed of polymers with π-electron delocalized backbones can be designed PTT performance, because clear structure-property relation versatility modifying molecular structures tune photophysical properties. This review summarizes recent advances photoacoustic applications semiconducting a focus on signal amplification second near-infrared (NIR-II, 1000-1700 nm) construction. The strategies such as screening, fluorescence quenching, accelerated heat dissipation, size-dependent dissipation first discussed brightness SPNs vivo PA. approaches shifting absorption NIR-II then introduced so improve tissue penetration depth therapy. At last, current challenges perspectives field discussed.

Language: Английский

---

Near‐Infrared Afterglow Semiconducting Nano‐Polycomplexes for the Multiplex Differentiation of Cancer Exosomes

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(15), P. 4983 - 4987

Published: Jan. 31, 2019

The detection of exosomes is promising for the early diagnosis cancer. However, development suitable optical sensors remains challenging. We have developed first luminescent nanosensor multiplex differentiation cancer that bypasses real-time light excitation. sensor composed a near-infrared semiconducting polyelectrolyte (ASPN) forms complex with quencher-tagged aptamer. afterglow signal nanocomplex (ASPNC), being initially quenched, turned on in presence aptamer-targeted exosomes. Because takes place after excitation, background signals are minimized, leading to an improved limit nearly two orders magnitude lower than fluorescence cell culture media. Also, ASPNC can be easily tailored detect different exosomal proteins by changing aptamer sequence. This enables orthogonal analysis multiple exosome samples, potentially permitting accurate identification cellular origin diagnosis.

Language: Английский

---

BSA‐IrO₂: Catalase‐like Nanoparticles with High Photothermal Conversion Efficiency and a High X‐ray Absorption Coefficient for Anti‐inflammation and Antitumor Theranostics

Angewandte Chemie International Edition, Journal Year: 2018, Volume and Issue: 57(32), P. 10309 - 10313

Published: June 11, 2018

Intrinsically integrating precise diagnosis, effective therapy, and self-anti-inflammatory action into a single nanoparticle is attractive for tumor treatment future clinical application, but still remains great challenge. In this study, bovine serum albumin-iridium oxide nanoparticles (BSA-IrO2 NPs) with extraordinary photothermal conversion efficiency, good photocatalytic activity, high X-ray absorption coefficient were prepared through one-step biomineralization. The allow phototherapy simultaneous photoacoustic/thermal imaging computed tomography. More importantly, BSA-IrO2 NPs can also act as catalase to protect normal cells against H2 O2 -induced reactive oxygen pressure inflammation while significantly enhancing photoacoustic microbubble-based inertial cavitation. These remarkable features may open up the exploration iridium-based nanomaterials in theranostics.

Language: Английский

---

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: July 5, 2023

Abstract Transient receptor potential (TRP) channels are sensors for a variety of cellular and environmental signals. Mammals express total 28 different TRP channel proteins, which can be divided into seven subfamilies based on amino acid sequence homology: TRPA (Ankyrin), TRPC (Canonical), TRPM (Melastatin), TRPML (Mucolipin), TRPN (NO-mechano-potential, NOMP), TRPP (Polycystin), TRPV (Vanilloid). They class ion found in numerous tissues cell types permeable to wide range cations such as Ca 2+ , Mg Na + K others. responsible various sensory responses including heat, cold, pain, stress, vision taste activated by number stimuli. Their predominantly location the surface, their interaction with physiological signaling pathways, unique crystal structure make TRPs attractive drug targets implicate them treatment diseases. Here, we review history discovery, summarize structures functions family, highlight current understanding role pathogenesis human disease. Most importantly, describe channel-related therapeutic interventions diseases limitations targeting clinical applications.

Language: Английский

---

Hydrogen Sulfide-Activatable Second Near-Infrared Fluorescent Nanoassemblies for Targeted Photothermal Cancer Therapy

Nano Letters, Journal Year: 2018, Volume and Issue: 18(10), P. 6411 - 6416

Published: Sept. 21, 2018

Near-infrared (NIR)-II fluorescence agents hold great promise for deep-tissue photothermal therapy (PTT) of cancers, which nevertheless remains restricted by the inherent nonspecificity and toxicity PTT. In response to this challenge, we herein develop a hydrogen sulfide (H2S)-activatable nanostructured agent (Nano-PT) site-specific NIR-II fluorescence-guided PTT colorectal cancer (CRC). Our in vivo studies reveal that theranostic Nano-PT probe is specifically activated H2S-rich CRC tissues, whereas it nonfunctional normal tissues. Activation not only emits with deeper tissue penetration ability than conventional fluorescent probes but also generates high NIR absorption resulting efficient conversion under laser irradiation. Importantly, establish imaging-guided applying tumor-bearing mice, results complete tumor regression minimal nonspecific damages. thus shed light on development biomarker-activated precision medicine.

Language: Английский

---