A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 13(1)

Published: July 9, 2021

Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress nanozymes has been made with deep investigation of diverse and rapid development related nanotechnologies. As promising alternatives for natural enzymes, have broadened way toward clinical medicine, food safety, environmental monitoring, chemical production. The past decade witnessed metal- metal oxide-based owing their remarkable physicochemical properties parallel low cost, high stability, easy storage. It is widely known that study catalytic activities mechanism sheds significant influence on applications nanozymes. This review digs into characteristics intrinsic nanozymes, especially emphasizing recent biological analysis, relieving inflammation, antibacterial, cancer therapy. We also conclude present challenges provide insights future constituted oxide nanomaterials.

Language: Английский

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Inorganic nanomaterials with rapid clearance for biomedical applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8669 - 8742

Published: Jan. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Language: Английский

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Nanozymes: Activity origin, catalytic mechanism, and biological application

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 448, P. 214170 - 214170

Published: Aug. 26, 2021

Language: Английский

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Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Jan. 7, 2021

Emerging artificial enzymes with reprogrammed and augmented catalytic activity substrate selectivity have long been pursued sustained efforts. The majority of current candidates rely on noble metals or transition metal oxides rather poor compared natural molecules. To tackle this limitation, we strategically designed a novel enzyme based structurally well-defined Au25 cluster, namely clusterzyme, which is endowed intrinsic high driven by single-atom substitutions modulated bond lengths. 3-mercaptopropionic acid (MPA)-stabilized Au24Cu1 Au24Cd1 clusterzymes exhibit 137 160 times higher antioxidant capacities than the trolox, respectively. Meanwhile, each demonstrate preferential enzyme-mimicking activities compelling selectivity: exhibits superior glutathione peroxidase-like (GPx-like) activity; shows distinct advantage towards catalase-like (CAT-like) its Cu single active site; preferably acts as superoxide dismutase-like (SOD-like) via Cd site. This unique diversified landscape manifests distinctive reactions against inflammation in brain. behaves an endogenous multi-enzyme mimic that directly decreases peroxide injured brain reactions, while Au24Cd1, catalyzes nitrogenous signal molecules preference, significantly factors such IL-1\b{eta}, IL-6, TNF{\alpha}, indicative important role mitigating neuroinflammation.

Language: Английский

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Red Emissive Carbon Dot Superoxide Dismutase Nanozyme for Bioimaging and Ameliorating Acute Lung Injury

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(19)

Published: Jan. 29, 2023

Abstract Harnessing the physiochemical properties and enzymatic activities of nanozymes will provide new insights for disease theranostics. Herein, a novel carbon dot (C‐dot) superoxide dismutase (SOD) nanozyme that exhibits red fluorescence with emission wavelength 683 nm shows high SOD‐like activity >4000 U mg −1 is reported, which presents great potential imaging biodistribution itself in vivo ameliorating acute lung injury. Through surface modifications, mechanism C‐dot SOD revealed to be relied on their functional groups bind radicals, promote electron transfer between C‐dots finally accelerate dismutation radicals. The absolute quantum yield ≈14% endow it bioimaging vitro vivo. Moreover, effectively enters cells, accumulates at mitochondria, protects living cells from oxidative damage by scavenging reactive oxygen species (ROS) reducing levels pro‐inflammatory factors. Importantly, animal experiments demonstrate accumulation injure therapeutic effect toward injury mice. fluorescent management ROS‐related diseases.

Language: Английский

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Prussian Blue Nanozyme as a Pyroptosis Inhibitor Alleviates Neurodegeneration

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(15)

Published: Feb. 10, 2022

Current pharmacological interventions for Parkinson's disease (PD) remain unsatisfactory in clinical settings. Inflammasome-mediated pyroptosis represents a potential therapeutic target the alleviation of neurodegenerative diseases. The development inflammasome-mediated agonists or antagonists may transform treatment However, identification specific compounds that inhibit remains challenging. Herein, Prussian blue nanozyme (PBzyme) is revealed as inhibitor to alleviate neurodegeneration mouse and cell models PD. PBzyme protects microglia neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). alleviates motor deficits, attenuates damage mitochondrial membrane potential, rescues dopaminergic neurons. Furthermore, intra-cerebroventricular injection reduces degeneration inhibits neuroinflammation an MPTP-induced PD model. Both vitro vivo results demonstrate activation microglial nucleotide-binding domain leucine-rich repeat family pyrin containing 3 (NLRP3) inflammasomes caspase-1 by scavenging reactive oxygen species, thereby downregulating gasdermin D (GSDMD) cleavage well inflammatory factor production, eventually leading inhibition pyroptosis. Overall, this work highlights neuroprotective effects provides valuable mechanistic insights strategy

Language: Английский

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Ultrasmall Rhodium Nanozyme with RONS Scavenging and Photothermal Activities for Anti-Inflammation and Antitumor Theranostics of Colon Diseases

Nano Letters, Journal Year: 2020, Volume and Issue: 20(5), P. 3079 - 3089

Published: April 29, 2020

Colitis-associated colorectal cancer (CAC), in which chronic inflammation is a well-recognized carcinogen, requires concurrent anti-inflammation and antitumor treatments the clinic. Herein, we report polyethylene glycol (PEG)-coated (PEGylated) ultrasmall rhodium nanodots (Rh-PEG NDs) can serve as metallic nanozyme with reactive oxygen nitrogen species (RONS) scavenging properties well photothermal activities for theranostics colon diseases. Benefiting from multienzyme against RONS, Rh-PEG NDs decrease levels of pro-inflammatory cytokines (TNF-α, IL-6), resulting good anti-inflammatory effect on dextran sulfate sodium-induced colitis. By virtue high conversion efficiency (48.9%), demonstrate complete ablation CT-26 tumor without any recurrence. Most importantly, exhibit biocompatibility both at cellular animal levels. Our findings provide paradigm to utilize nanozymes potential management

Language: Английский

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Hierarchically Porous S/N Codoped Carbon Nanozymes with Enhanced Peroxidase-like Activity for Total Antioxidant Capacity Biosensing

Analytical Chemistry, Journal Year: 2020, Volume and Issue: 92(19), P. 13518 - 13524

Published: Sept. 1, 2020

Design of highly active carbon nanozymes and further establishment ultrasensitive biosensors remain a challenge. Herein, hierarchically porous with sulfur (S)/nitrogen (N) codoping (SNC) were developed. Compared N-doped (NC) nanozymes, SNC have smaller Michaelis–Menten constant higher specific activities, demonstrating that the S-doping in could not only enhance their affinity toward substrates but also improve catalytic performance. These results may be caused by synergistic effect heteroatoms (S N). Because good enzyme-like activity, proposed exploited to colorimetric detection total antioxidant capacity (TAC) using ascorbic acid as typical model limit 0.08 mM. its high sensitivity selectivity encouraging performance, method presented practical feasibility for TAC assay commercial beverages. This work paves way design expand applications construction high-performance biosensors.

Language: Английский

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Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(31)

Published: May 13, 2021

Abstract In human systems, reactive oxygen species (ROS) significantly affect different physiological activities and play critical roles in diverse living processes. It is widely known that excessive ROS generation inflammatory tissues can further deteriorate the localized tissue injury cause chronic diseases. Though promising for reducing levels, many antioxidant molecules natural enzymes suffer from abundant intrinsic limitations. Recently, a series of biocatalytic or nanostructures have been designed with distinctive scavenging capabilities, which show to overcome these kernel challenges. this timely review, most recent advances engineering are summarized. First, principles corresponding methods testing various enzymatic carefully concluded. Subsequently, rationally high efficiencies comprehensively discussed, especially on catalytic activities, mechanisms, structure‐function relationships. After that, representative applications biotherapeutics summarized detail. At last, primary challenges future perspectives emerging research frontier also outlined. believed progress review will offer cutting‐edge understanding guidance high‐performance broad biotherapeutic applications.

Language: Английский

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Carbon-based nanozymes: Design, catalytic mechanism, and bioapplication

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 475, P. 214896 - 214896

Published: Oct. 27, 2022

Language: Английский

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