A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 13(1)

Published: July 9, 2021

Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress nanozymes has been made with deep investigation of diverse and rapid development related nanotechnologies. As promising alternatives for natural enzymes, have broadened way toward clinical medicine, food safety, environmental monitoring, chemical production. The past decade witnessed metal- metal oxide-based owing their remarkable physicochemical properties parallel low cost, high stability, easy storage. It is widely known that study catalytic activities mechanism sheds significant influence on applications nanozymes. This review digs into characteristics intrinsic nanozymes, especially emphasizing recent biological analysis, relieving inflammation, antibacterial, cancer therapy. We also conclude present challenges provide insights future constituted oxide nanomaterials.

Language: Английский

---

Inorganic nanomaterials with rapid clearance for biomedical applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8669 - 8742

Published: Jan. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Language: Английский

---

Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(2), P. 107518 - 107518

Published: May 14, 2022

Language: Английский

---

Design of therapeutic biomaterials to control inflammation

Nature Reviews Materials, Journal Year: 2022, Volume and Issue: 7(7), P. 557 - 574

Published: Feb. 28, 2022

Language: Английский

---

Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 11, 2023

Nanozymes with superoxide dismutase (SOD)-like activity have attracted increasing interest due to their ability scavenge anion, the origin of most reactive oxygen species in vivo. However, SOD nanozymes reported thus far yet approach natural enzymes. Here, we report a carbon dot (C-dot) nanozyme catalytic over 10,000 U/mg, comparable that Through selected chemical modifications and theoretical calculations, show SOD-like C-dots relies on hydroxyl carboxyl groups for binding anions carbonyl conjugated π-system electron transfer. Moreover, C-dot exhibit intrinsic targeting oxidation-damaged cells effectively protect neuron ischemic stroke male mice model. Together, our study sheds light structure-activity relationship nanozymes, demonstrates potential treating oxidation stress related diseases.

Language: Английский

---

Superoxide dismutase nanozymes: an emerging star for anti-oxidation

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(35), P. 6939 - 6957

Published: Jan. 1, 2021

This review summarizes catalytic mechanisms, regulatory factors, measurement methods and various applications of SOD-like nanozymes, as well proposes the current challenges prospects in development nanozymes.

Language: Английский

---

Nanozymes: Activity origin, catalytic mechanism, and biological application

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 448, P. 214170 - 214170

Published: Aug. 26, 2021

Language: Английский

---

Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery

ACS Nano, Journal Year: 2021, Volume and Issue: 15(2), P. 2263 - 2280

Published: Jan. 11, 2021

Oxidative stress and a series of excessive inflammatory responses are major obstacles for neurological functional recovery after ischemic stroke. Effective noninvasive anti-inflammatory therapies urgently needed. However, unsatisfactory therapeutic efficacy current drugs inadequate drug delivery to the damaged brain problems. Nanozymes with robust antioxidative properties possess possibility insufficiency nanozyme accumulation in by administration hindered their application. Herein, we report neutrophil-like cell-membrane-coated mesoporous Prussian blue (MPBzyme@NCM) realize active-targeting therapy stroke improving based on innate connection between inflamed microvascular endothelial cells neutrophils The long-term vivo MPBzyme@NCM was illustrated detail being delivered into uptake microglia. Moreover, detailed mechanism via microglia further studied, including polarization toward M2, reduced recruitment neutrophils, decreased apoptosis neurons, proliferation neural stem cells, neuronal precursors, neurons. This strategy may provide an applicative perspective diseases.

Language: Английский

---

Recent applications of immunomodulatory biomaterials for disease immunotherapy

Exploration, Journal Year: 2022, Volume and Issue: 2(6)

Published: May 23, 2022

Immunotherapy is used to regulate systemic hyperactivation or hypoactivation treat various diseases. Biomaterial-based immunotherapy systems can improve therapeutic effects through targeted drug delivery, immunoengineering, etc. However, the immunomodulatory of biomaterials themselves cannot be neglected. In this review, we outline with functions discovered in recent years and their applications disease treatment. These inflammation, tumors, autoimmune diseases by regulating immune cell function, exerting enzyme-like activity, neutralizing cytokines, The prospects challenges biomaterial-based modulation are also discussed.

Language: Английский

---

Nanoparticles in Clinical Translation for Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1685 - 1685

Published: Feb. 1, 2022

The advent of cancer therapeutics brought a paradigm shift from conventional therapy to precision medicine. new therapeutic modalities accomplished through the properties nanomaterials have extended their scope in beyond drug delivery. Nanoparticles can be channeled encapsulate active pharmaceutical ingredients and deliver them tumor site more efficient manner. This review enumerates various types nanoparticles that entered clinical trials for treatment. obstacles journey nanodrug clinic market are reviewed. Furthermore, latest developments using also highlighted.

Language: Английский

---