Depletable peroxidase-like activity of Fe3O4 nanozymes accompanied with separate migration of electrons and iron ions

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 12, 2022

As pioneering Fe

Language: Английский

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Advanced bioactive nanomaterials for biomedical applications

Exploration, Journal Year: 2021, Volume and Issue: 1(3)

Published: Dec. 1, 2021

Bioactive materials are a kind of with unique bioactivities, which can change the cellular behaviors and elicit biological responses from living tissues. came into spotlight in late 1960s when researchers found that such as bioglass could react surrounding bone tissue for regeneration. In following decades, advances nanotechnology brought new development opportunities to bioactive nanomaterials. nanomaterials not simple miniaturization macroscopic materials. They exhibit bioactivities due their nanoscale size effect, high specific surface area, precise nanostructure, significantly influence interactions systems. Nowadays, have represented an important exciting area research. Current future applications ensure academic clinical importance. This review summaries recent field nanomaterials, evaluate factors bioactivities. Then, range potential biomedical discussed. Furthermore, limitations, challenges, also

Language: Английский

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Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 25, 2023

Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years hold huge potential to be applied diverse fields, especially for biosensing therapeutics. Compared single nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, environmentally responsive selectivity. Nevertheless, along these merits, the catalytic mechanism rational design of complicated elusive as compared single-enzymic nanozymes. In this review, classification scheme based on numbers/types activities, internal external factors regulating multienzymatic chemical, biomimetic, computer-aided strategies, progress applications attributed advantages multicatalytic activities systematically discussed. Finally, current challenges future perspectives regarding development application suggested. This review aims deepen understanding inspire research a greater extent.

Language: Английский

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Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: April 6, 2022

Abstract Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, low yield, making them difficult to be broadly applicable. As an emerging type artificial enzyme, nanozymes that combine the characteristics nanomaterials are promising alternatives. On one hand, have enzyme-like catalytic activities regulate biochemical reactions. other also inherit properties nanomaterials, which can ameliorate shortcomings natural serve as versatile platforms for diverse applications. In this review, various mimic activity different introduced. The achievements in cancer diagnosis treatment technologies summarized by highlighting advantages these Finally, future research directions rapidly developing field outlooked."Image missing"

Language: Английский

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Nanozymes in Point-of-Care Diagnosis: An Emerging Futuristic Approach for Biosensing

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 13(1)

Published: Sept. 13, 2021

Nanomaterial-based artificial enzymes (or nanozymes) have attracted great attention in the past few years owing to their capability not only mimic functionality but also overcome inherent drawbacks of natural enzymes. Numerous advantages nanozymes such as diverse enzyme-mimicking activities, low cost, high stability, robustness, unique surface chemistry, and ease tunability biocompatibility allowed integration a wide range biosensing applications. Several metal, metal oxide, metal-organic framework-based been exploited for development systems, which present potential point-of-care analysis. To highlight recent progress field, this review, more than 260 research articles are discussed systematically with suitable examples, elucidating role reinforce, miniaturize, improve performance diagnostics addressing ASSURED (affordable, sensitive, specific, user-friendly, rapid robust, equipment-free deliverable end user) criteria formulated by World Health Organization. The review reveals that many strategies electrochemical, colorimetric, fluorescent, immunological sensors required achieve standards can be implemented using activities nanomaterials signal producing components. However, basic system is still lacking. Since properties dictated size, shape, composition, charge, chemistry well external parameters pH or temperature, these factors play crucial design function nanozyme-based diagnostics. Therefore, it requires deliberate exertion integrate various truly solutions realized. This discusses possible limitations gaps provide readers brief scenario emerging state-of-the-art POC diagnosis futuristic

Language: Английский

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Recent advances in targeted antibacterial therapy basing on nanomaterials

Exploration, Journal Year: 2023, Volume and Issue: 3(1)

Published: Feb. 1, 2023

Bacterial infection has become one of the leading causes death worldwide, particularly in low-income countries. Despite fact that antibiotics have provided successful management bacterial infections, long-term overconsumption and abuse contributed to emergence multidrug resistant bacteria. To address this challenge, nanomaterials with intrinsic antibacterial properties or serve as drug carriers been substantially developed an alternative fight against infection. Systematically deeply understanding mechanisms is extremely important for designing new therapeutics. Recently, nanomaterials-mediated targeted bacteria depletion either a passive active manner most promising approaches treatment by increasing local concentration around cells enhance inhibitory activity reduce side effects. Passive targeting approach widely explored searching nanomaterial-based alternatives antibiotics, while strategy relies on biomimetic biomolecular surface feature can selectively recognize In review article, we summarize recent developments field therapy based nanomaterials, which will promote more innovative thinking focusing multidrug-resistant

Language: Английский

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Carbon-based nanozymes: Design, catalytic mechanism, and bioapplication

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 475, P. 214896 - 214896

Published: Oct. 27, 2022

Language: Английский

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Nanozyme Catalytic Turnover and Self-Limited Reactions

ACS Nano, Journal Year: 2021, Volume and Issue: 15(10), P. 15645 - 15655

Published: Oct. 8, 2021

Enzymes have catalytic turnovers. The field of nanozyme endeavors to engineer nanomaterials as enzyme mimics. However, a discrepancy in the definition "nanozyme concentration" has led an unrealistic calculation To date, most reported works considered either atomic concentration or nanoparticle (NP) concentration. These assumptions can lead significant under- overestimation activity nanozymes. In this article, we review some classic nanozymes including Fe3O4, CeO2, and gold nanoparticles (AuNPs) with focus on activities. We argue that only surface atoms should be active sites, then turnover numbers rates were recalculated based atoms. According calculations, peroxidase Fe3O4 NPs is validated. AuNPs are self-limited when performing glucose-oxidase like activity, but they also true catalysts. For CeO2 NPs, behavior observed for both oxidase- phosphatase-like activities due adsorption reaction products. Moreover, single-atom discussed. Finally, few suggestions future research proposed.

Language: Английский

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Single‐Atomic Iron Doped Carbon Dots with Both Photoluminescence and Oxidase‐Like Activity

Small, Journal Year: 2022, Volume and Issue: 18(37)

Published: Aug. 19, 2022

Abstract Multifunctional nanozymes can benefit biochemical analysis via expanding sensing modes and enhancing analytical performance, but designing multifunctional to realize the desired of targets is challenging. In this work, single‐atomic iron doped carbon dots (SA Fe‐CDs) are designed synthesized a facile in situ pyrolysis process. The small‐sized CDs not only maintain their tunable fluorescence, also serve as support for loading dispersed active sites. Monoatomic Fe offers SA Fe‐CDs exceptional oxidase‐mimetic activity catalyze 3,3′,5,5′‐tetramethylbenzidine (TMB) oxidation with fast response ( V max = 10.4 nM s ‐1 ) strong affinity K m 168 µM). Meanwhile, photoluminescence quenched by product TMB due inner filter effect. Phosphate ions (Pi) suppress oxidase‐mimicking restore interacting Based on principle, dual‐mode colorimetric fluorescence assay Pi high sensitivity, selectivity, rapid established. This work paves path develop enzyme‐like catalysts, simple efficient method phosphate monitoring, which will inspire exploration multi‐mode strategies based nanozyme catalysis.

Language: Английский

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Self-Driven Electron Transfer Biomimetic Enzymatic Catalysis of Bismuth-Doped PCN-222 MOF for Rapid Therapy of Bacteria-Infected Wounds

ACS Nano, Journal Year: 2023, Volume and Issue: 17(2), P. 1448 - 1463

Published: Jan. 9, 2023

In this work, a biomimetic nanozyme catalyst with rapid and efficient self-bacteria-killing wound-healing performances was synthesized. Through an in situ reduction reaction, PCN-222 metal organic framework (MOF) doped bismuth nanoparticles (Bi NPs) to form Bi-PCN-222, interfacial Schottky heterojunction catalyst, which can kill 99.9% of Staphylococcus aureus (S. aureus). The underlying mechanism that Bi NP doping endow Bi-PCN-222 MOF self-driven charge transfer through the interface capability oxidase-like peroxidase-like activity, because large number free electrons be captured by surrounding oxygen species produce radical (ROS). Furthermore, once bacteria contact physiological environment, its appropriate redox potential trigger electron transport pathway bacterial membranes then interior bacteria, disturbs respiration process subsequent metabolism. Additionally, also accelerate tissue regeneration upregulating fibroblast proliferation angiogenesis genes (bFGF, VEGF, HIF-1α), thereby promoting wound healing. This enzyme-catalyzed strategy will bring enlightenment design self-bacterial agents for disinfection reconstruction simultaneously.

Language: Английский

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