Platinum-Doped Prussian Blue Nanozymes for Multiwavelength Bioimaging Guided Photothermal Therapy of Tumor and Anti-Inflammation

ACS Nano, Journal Year: 2021, Volume and Issue: 15(3), P. 5189 - 5200

Published: March 11, 2021

Developing appropriate photothermal agents to meet complex clinical demands is an urgent challenge for therapy of tumors. Here, platinum-doped Prussian blue (PtPB) nanozymes with tunable spectral absorption, high conversion efficiency, and good antioxidative catalytic activity are developed by one-step reduction. By controlling the doping ratio, PtPB exhibit localized surface plasmon resonance (LSPR) frequency significantly enhanced efficiency allow multiwavelength photoacoustic/infrared thermal imaging guided therapy. Experimental band gap density functional theory calculations further reveal that decrement free carrier concentrations increase in circuit paths electron transitions co-contribute LSPR frequency. Benefiting from activity, can simultaneously relieve inflammation caused hyperthermia. Moreover, exhibited biosafety after intravenous injection. Our findings provide a paradigm designing safe efficient treat tumor diseases.

Language: Английский

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Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(31)

Published: May 13, 2021

Abstract In human systems, reactive oxygen species (ROS) significantly affect different physiological activities and play critical roles in diverse living processes. It is widely known that excessive ROS generation inflammatory tissues can further deteriorate the localized tissue injury cause chronic diseases. Though promising for reducing levels, many antioxidant molecules natural enzymes suffer from abundant intrinsic limitations. Recently, a series of biocatalytic or nanostructures have been designed with distinctive scavenging capabilities, which show to overcome these kernel challenges. this timely review, most recent advances engineering are summarized. First, principles corresponding methods testing various enzymatic carefully concluded. Subsequently, rationally high efficiencies comprehensively discussed, especially on catalytic activities, mechanisms, structure‐function relationships. After that, representative applications biotherapeutics summarized detail. At last, primary challenges future perspectives emerging research frontier also outlined. believed progress review will offer cutting‐edge understanding guidance high‐performance broad biotherapeutic applications.

Language: Английский

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Integrating Pt nanoparticles with carbon nanodots to achieve robust cascade superoxide dismutase-catalase nanozyme for antioxidant therapy

Nano Today, Journal Year: 2023, Volume and Issue: 49, P. 101768 - 101768

Published: Feb. 3, 2023

Language: Английский

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Nanozymes for Regenerative Medicine

Small Methods, Journal Year: 2022, Volume and Issue: 6(11)

Published: Oct. 6, 2022

Abstract Nanozymes refer to nanomaterials that catalyze enzyme substrates into products under relevant physiological conditions following kinetics. Compared natural enzymes, nanozymes possess the characteristics of higher stability, easier preparation, and lower cost. Importantly, magnetic, fluorescent, electrical properties nanomaterials, making them promising replacements for enzymes in industrial, biological, medical fields. On account rapid development recently, their application potentials regeneration medicine are gradually being explored. To highlight achievements field, this review summarizes catalytic mechanism four types representative nanozymes. Then, strategies improve biocompatibility discussed. covers recent advances tissue including wound healing, nerve defect repair, bone regeneration, cardiovascular disease treatment. In addition, challenges prospects nanozyme researches summarized.

Language: Английский

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Piezoelectricity, Pyroelectricity, and Ferroelectricity in Biomaterials and Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Oct. 16, 2023

Abstract Piezoelectric, pyroelectric, and ferroelectric materials are considered unique biomedical due to their dielectric crystals asymmetric centers that allow them directly convert various primary forms of energy in the environment, such as sunlight, mechanical energy, thermal into secondary electricity chemical energy. These possess exceptional conversion ability excellent catalytic properties, which have led widespread usage within fields. Numerous applications demonstrated great potential with these materials, including disease treatment, biosensors, tissue engineering. For example, piezoelectric used stimulate cell growth bone regeneration, while pyroelectric applied skin cancer detection imaging. Ferroelectric even found use neural implants record electrical activity brain. This paper reviews relationship between ferroelectric, piezoelectric, effects fundamental principles different reactions. It also highlights preparation methods three significant progress made applications. The review concludes by presenting key challenges future prospects for efficient catalysts based on nanomaterials

Language: Английский

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Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 354, P. 1 - 18

Published: Dec. 27, 2022

Language: Английский

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Radicals Scavenging MOFs Enabling Targeting Delivery of siRNA for Rheumatoid Arthritis Therapy

Small, Journal Year: 2022, Volume and Issue: 18(27)

Published: June 3, 2022

Abstract Macrophages play essential roles in the progression of rheumatoid arthritis (RA), which are polarized into pro‐inflammatory M1 phenotype with significant oxidative stress and cytokines excretion. Herein, an active targeting nanomedicine based on metal‐organic frameworks (MOFs) to re‐educate diseased macrophages for RA therapy is reported. The MOFs prepared via coordination between tannic acid (TA) Fe 3+ , anti‐TNF‐α siRNA loaded a simple sonication process, achieving high loading capacity comparable cationic vectors. show excellent biocompatibility, enable rapid endo/lysosome escape proton‐sponge effect effective down‐regulation. Importantly, such displays intrinsic radicals scavenging capability eliminate broad spectrum reactive oxygen nitrogen species (RONS), turn repolarizes anti‐inflammatory M2 phenotypes enhanced combination siRNA. further modified bovine serum albumin (BSA) allow cascade joint targeted delivery. As result, anti‐RA efficacy achieved collagen‐induced mice model. This work provides robust gene vector great translational potential, offers vivid example rationally designing MOF structure multifunctionalities synergize its payload disease treatment.

Language: Английский

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Designing nanozymes for in vivo applications

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(10), P. 849 - 868

Published: July 18, 2024

Language: Английский

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RhRu Alloy‐Anchored MXene Nanozyme for Synergistic Osteosarcoma Therapy

Small, Journal Year: 2023, Volume and Issue: 19(22)

Published: March 4, 2023

Noble metal nanozymes hold promise in cancer therapy due to adjustable enzyme-like activities, unique physicochemical properties, etc. But catalytic activities of monometallic nanozyme are confined. In this study, 2D titanium carbide (Ti3 C2 Tx )-supported RhRu alloy nanoclusters (RhRu/Ti3 ) prepared by a hydrothermal method and utilized for synergistic chemodynamic (CDT), photodynamic (PDT), photothermal (PTT) on osteosarcoma. The small size (3.6 nm), uniform distribution, have excellent catalase (CAT) peroxidase (POD)-like activities. Density functional theory calculations show that there is significant electron transfer interaction between Ti3 , which has strong adsorption H2 O2 beneficial enhance the activity. Furthermore, RhRu/Ti3 acts as both PTT agent converting light into heat, photosensitizer catalyzing 1 . With NIR-reinforced POD- CAT-like activity, performance, CDT/PDT/PTT effect osteosarcoma verified vitro vivo experiments. This study expected provide new research direction treatment other tumors.

Language: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

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