Chemical Communications,
Journal Year:
2022,
Volume and Issue:
58(51), P. 7200 - 7203
Published: Jan. 1, 2022
A
photoredox/copper
cocatalyzed
domino
cyclization
of
oxime
esters
with
TMSCN
has
been
developed.
range
structurally
novel
tetrasubstituted
pyrazines
have
obtained.
This
method
features
high
bond-forming
efficiency,
step
economy,
broad
substrate
scope,
and
gram-scale
synthesis.
Moreover,
preliminary
bioactivity
evaluation
pyrazine
products
shows
their
promising
antifungal
activities.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(5), P. 838 - 842
Published: Jan. 27, 2023
A
copper-catalyzed
annulation
of
O-acyl
oximes
with
cyclic
1,3-diones
has
been
developed
for
the
concise
synthesis
7,8-dihydroindolizin-5(6H)-ones
and
cyclohexanone-fused
furans
through
substituent-controlled
selective
radical
coupling
process.
2-Alkyl
undergo
C-C
coupling,
while
2-unsubstituted
C-O
coupling.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(21), P. 3828 - 3833
Published: May 23, 2022
A
copper-catalyzed
annulation
of
α,β-unsaturated
O-acyl
ketoximes
with
isoquinolinium
N-ylides
has
been
developed
for
the
concise
synthesis
stable
N-H
imines
a
benzo[7,8]indolizine
core.
When
β-(2-bromoaryl)-α,β-unsaturated
are
used
as
starting
materials,
cascade
cyclization
occurs
to
afford
benzo[7,8]indolizino[1,2-c]quinolines.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(28), P. 5137 - 5142
Published: July 8, 2022
An
efficient,
one-pot
approach
has
been
established
for
synthesizing
a
wide
range
of
3-amino-[1,2,4]-triazolo
pyridines
and
related
heterocycles
from
the
electrochemically
induced
desulfurative
cyclization
2-hydrazinopyridines
with
isothiocyanates.
The
protocol
allows
formation
C–N
bonds
under
simple
conditions
without
transition
metals
or
external
oxidants.
practicability
this
strategy
is
demonstrated
by
its
broad
substrate
scope,
good
functional
group
compatibility,
gram-scale
synthesis.
late-stage
modification
enables
us
to
obtain
several
molecules
potent
anticancer
activity.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(5), P. 2797 - 2808
Published: Jan. 25, 2022
A
[3+1+1+1]
annulation
of
arylamines,
arylaldehydes,
and
dimethyl
sulfoxide
(DMSO)
to
the
pyridine
structure
in
quinolines
using
DMSO
as
a
nonadjacent
dual-methine
(═CH-)
synthon
is
disclosed.
In
this
annulation,
arylamines
provide
two
carbon
atoms
one
nitrogen
atom,
arylaldehydes
furnish
provides
methines
ring
quinoline
molecules.
This
simple
approach
for
synthesis
3-arylquinolines
from
readily
available
substrates
useful
yields.
On
basis
control
experiments
literature,
plausible
mechanism
proposed.
Organic Process Research & Development,
Journal Year:
2020,
Volume and Issue:
24(6), P. 909 - 915
Published: May 14, 2020
Nonprecious
metal
catalysis
is
a
highly
active
area
of
research
for
both
industrial
and
academic
laboratories.
New
methods
that
efficiently
generate
useful
functionality
in
cost-effective,
high
yielding,
environmentally
friendly
ways
naturally
garner
attention
from
process
chemists
many
different
industries.
This
series
highlights
summarizes
literature
on
the
general
topic
nonprecious
over
four-month
timeframes
will
focus
major
trends
field
are
interest
pharmaceutical
industry.
The
first
installment
selected
transformations
using
copper,
nickel,
iron
catalysts.
Organic Letters,
Journal Year:
2021,
Volume and Issue:
23(22), P. 9000 - 9005
Published: Nov. 8, 2021
An
efficient
iodine-imine
synergistic
promoted
Povarov-type
multicomponent
reaction
was
reported
for
the
synthesis
of
a
practical
2,2′-biquinoline
scaffold.
The
tandem
annulation
has
reconciled
iodination,
Kornblum
oxidation,
and
Povarov
aromatization,
where
methyl
group
azaarenes
represents
uniquely
reactive
input
in
reaction.
This
method
broad
substrate
scope
mild
conditions.
Furthermore,
these
derivatives
had
been
directly
used
as
bidentate
ligands
metal-catalyzed
reactions.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(9), P. 5804 - 5816
Published: April 27, 2022
An
efficient
Cu-catalyzed
annulation
reaction
of
ketone
oxime
acetates
with
ortho-trifluoroacetyl
anilines
has
been
disclosed.
With
the
developed
protocol,
a
series
4-trifluoromethyl
quinolines
were
obtained
in
good
to
excellent
yields
(58-99%)
under
redox-neutral
conditions.
The
protocol
also
could
be
extended
ferrocene-based
for
construction
ferrocene-substituted
fluorine-containing
quinolines.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
A
copper-catalyzed
[4
+
2]
annulation
protocol
from
readily
available
α,β-unsaturated
ketoximes
and
dialkyl
acetylenedicarboxylates
has
been
achieved.
The
approach
enables
the
expedient
construction
of
a
series
structurally
new
highly
substituted
pyridines
with
good
functional
group
tolerance.
