Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(11), P. 2440 - 2446
Published: Jan. 1, 2023
A
novel
approach
for
the
production
of
halogen
cations
through
reaction
halogens
with
silver
ions
is
described
in
this
paper.
On
basis,
regioselective
synthesis
3-haloquinolines
and
3-halospirocyclohexadienones
realized
solvent
regulation.
The
gram-scale
compatibility
complex
substrates
demonstrate
synthetic
potential
protocol,
which
will
be
an
appealing
strategy
organic
synthesis.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(5), P. 1146 - 1151
Published: Feb. 3, 2022
A
novel
photo-thermo-mechanochemical
approach
to
assembling
quinolines
catalyzed
by
iron(II)
phthalocyanine
has
been
realized
for
the
first
time.
This
transformation
features
a
cost-efficient
catalytic
system
and
operational
simplicity,
is
free
of
solvent,
shows
good
substrate
tolerance,
providing
green
alternative
existing
thermal
approaches.
Mechanistic
experiments
demonstrate
that
in-situ-formed
secondary
amine
may
be
key
intermediate
further
cyclization/aromatization
process.
New Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
48(17), P. 7614 - 7638
Published: Jan. 1, 2024
In
the
iodine–DMSO
medium,
methyl
group
of
azaarenes
is
converted
into
aldehyde
via
Kornblum
oxidation
and
trapped
in
situ
by
nucleophiles
to
create
azaarene-linked
functionalized
scaffolds.
Asian Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Nov. 26, 2022
Abstract
In
multicomponent
reactions,
three
or
more
reactants
combine
in
one
pot
to
form
a
product
without
the
isolation
of
intermediate
and
most
contribute
newly
formed
reducing
number
steps
involved
waste
generated.
Molecular
iodine
is
mild,
efficient,
relatively
nontoxic,
inexpensive,
commercially
available,
catalyzes
various
organic
reactions
due
its
Lewis
acidic
behaviour.
The
development
catalyzed
by
molecular
indeed
good
green
alternative
for
synthetic
chemistry.
aim
this
article
review
all
important
reported
since
2013
order
envisage
some
new
efficient
protocols
synthesis
structurally
complex
molecules.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(6), P. 1348 - 1355
Published: Jan. 13, 2024
Abstract
A
total
synthesis
strategy
was
developed
for
the
of
luotonin
A,
B
and
their
analogues
using
synergistic
FeCl
3
/KI‐catalyzed
oxidative
cyclization.
This
protocol
utilizes
cheap
widely
available
N
‐propargyl
2‐methyl‐quinazolinones
arylamines
under
mild
conditions,
it
has
a
wide
substrate
scope
high
atom
economy.
Different
natural
products
(luotonin
derivatives)
can
be
synthesized
via
unique
switchable
approach.
Further
transformations
from
to
E
structural
modification
demonstrate
potential
applications
this
method.
Moreover,
camptothecin
also
modified
with
reported
afford
hydroxyl‐substituted
product.
ChemistryOpen,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 11, 2024
Abstract
This
review
introduces
the
synthetic
organic
chemical
value
of
α‐bromocarbonyl
compounds
with
tertiary
carbons.
compound
a
carbon
has
been
used
primarily
only
as
radical
initiator
in
atom
transfer
polymerization
(ATRP)
reactions.
However,
recent
development
photo‐radical
reactions
(around
2010),
research
on
use
alkyl
precursors
became
popular
2012).
As
more
examples
were
reported,
studied
not
radicals
but
also
for
their
applications
organometallic
and
ionic
That
is,
act
nucleophiles
well
electrophiles.
The
carbonyl
group
is
attractive
because
it
allows
skeleton
to
be
converted
after
reaction,
being
applied
total
synthesis.
In
our
survey
until
2022,
can
perform
full
range
necessary
synthesis,
including
multi‐component
reactions,
cross‐coupling,
substitution,
cyclization,
rearrangement,
stereospecific
asymmetric
α‐Bromocarbonyl
have
created
new
trend
alkylation,
which
then
had
limited
reaction
patterns
focuses
how
chemistry.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(3)
Published: Jan. 17, 2024
Abstract
Organic
synthesis
involves
the
production
of
important
chemical
structures
using
scalable
and
cost‐effective
methods
that
are
also
environmentally
friendly.
In
this
review,
a
detailed
analysis
use
iodine
DMSO
in
various
synthetic
routes
for
preparation
valuable
targets
presented.
These
reduce
acceptance
on
expensive
additives
reagents,
offer
more
sustainable
solution
these
scaffolds.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(17), P. 12832 - 12841
Published: Aug. 9, 2024
A
cascade
oxidation/Pictet–Spengler
condensation/annulation
process
has
been
developed
for
the
one-pot
total
synthesis
of
nitramarine,
nitraridine,
and
their
analogues.
The
procedure
proceeded
with
easily
available
quinolines
tryptophan
derivatives.
simple
metal-free
approach,
wide
substrate
scope,
functional
group
tolerance
make
it
applicable
diverse
bioactive
Furthermore,
bioactivity
evaluation
identified
two
promising
leading
compounds
5d
5e
potent
antitumor
proliferative
activity
against
breast
cancer
cells.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
25(1), P. 109 - 114
Published: Dec. 9, 2022
With
triethylamine
as
a
vinylene
source,
convenient
protocol
for
the
regioselective
synthesis
of
β,γ-nonsubstituted
2-arylquinolines
from
aldehydes
and
arylamines
has
been
accomplished.
The
deaminative
cyclization
is
also
extended
to
long-chain
tertiary
alkylamines,
enabling
diverse
alkyl
groups
be
concurrently
installed
into
pyridine
rings.
This
process
demonstrates
new
conversion
pathway
simultaneous
dual
C(sp3)-H
bond
functionalization
amines,
wherein
transient
acyclic
enamines
generated
in
situ
undergo
Povarov
reaction.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(21), P. 4385 - 4390
Published: Jan. 1, 2022
A
metal-free
three-component
protocol
for
quinoline
synthesis
is
developed
by
using
alkyl
lactates,
anilines
and
α-keto
acids.
In
vitro
experiments
disclose
the
attractive
anti-inflammatory
activity
of
these
compounds.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(4), P. 1121 - 1126
Published: Jan. 1, 2022
A
high-efficiency
strategy
for
the
synthesis
of
furoxans
and
1,2,4-oxadiazoles
has
been
developed,
using
tert
-butyl
nitrite
(TBN)
as
nitrogen
source.
Azaarene
nitrile
oxides
were
generated
in
situ
via
methyl
azaarenes
functionalization.
