Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 387 - 424
Published: Jan. 1, 2023
Language: Английский
Russian Chemical Reviews, Journal Year: 2024, Volume and Issue: 93(7), P. RCR5125 - RCR5125
Published: July 1, 2024
The chemistry of heterocyclic compounds has traditionally been and remains a bright area chemical science in Russia. This is due to the fact that many heterocycles find widest application. These are key structural fragments most drugs, plant protection agents. Many natural also derivatives heterocycles. At present, more than half hundreds millions known collective review devoted achievements Russian chemists this field over last 15–20 years. presents leading heterocyclists representing both RAS institutes university science. It worth noting wide scope review, terms geography author teams, covering whole our large country, diversity research areas. Practically all major types represented review. special attention focused on practical applications design new drugs biologically active compounds, high-energy molecules, materials for organic electronics photovoltaics, ligands coordination chemistry, other rapidly developing advances would not be possible without development fundamental transformations chemistry.<br> Bibliography — 2237 references.
Language: Английский
Citations
37
The Chemical Record, Journal Year: 2024, Volume and Issue: 24(6)
Published: June 1, 2024
Isatins have been widely used in the preparation of a variety heterocyclic compounds, where skeletal editing isatins has shown significant advantages for construction diverse heterocycles. This review highlights progress made last decade (2013-2023) isatin scaffold. A series ring expansion reactions quinoline skeleton, quinolone polycyclic quinazoline medium-sized as well opening generation 2-(azoly)aniline skeleton by cleavage C-C bond and C-N are highlighted. It is hoped that this will provide some understanding chemical transformations contribute to further realization its molecular diversity.
Language: Английский
Citations
5
Organic Letters, Journal Year: 2022, Volume and Issue: 24(5), P. 1232 - 1236
Published: Jan. 31, 2022
A palladium-catalyzed reaction of N-propargyl oxazolidines with alkenes for the synthesis indolizidines has been developed. Through a sequential 6-exo-dig cyclization/proton transfer/[3+2] cycloaddition/cycloreversion/aromatization process, series fused polycyclic indolizines are obtained in moderate to good yields high functional group tolerance. Experimental and theoretical studies suggest that [3+2] cycloaddition/cycloreversion oxazolidine ring probably involves C-C C-O bond cleavage, providing new restructuring approach heterocycles.
Language: Английский
Citations
20
Green Chemistry, Journal Year: 2022, Volume and Issue: 24(5), P. 1978 - 1982
Published: Jan. 1, 2022
A catalyst- and solvent-free, highly efficient, atom-economical synthesis strategy has been developed for the construction of 1,4-dicarbonyl motifs via hydrocarbonylation alkynes with propargylamines water.
Language: Английский
Citations
19
Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(18), P. 2223 - 2227
Published: May 14, 2024
Comprehensive Summary Allenes, served as highly sought‐after building blocks, are an indispensable component of synthetic chemistry. Their utility in modulating the chemical, physical, and pharmaceutical properties organic compounds make allenes a desirable choice various applications. Here, we report facile method for atom‐economical synthesis propargyl allenylamines via underdeveloped [2,3]‐sigmatropic rearrangement. Our strategy employs easily accessible propargylamines starting materials, which first converted into ammonium salts, followed by base‐promoted This one‐pot, two‐step reaction proceeds absence transition metals, displays very broad scope, does not require introduction electron‐withdrawing group materials.
Language: Английский
Citations
4
The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
Compared with the well-developed cyclization of functionalized propargylamines, use unactivated tertiary propargylamines to access pyrroles remains challenging. Herein, we report an efficient method for constructing tetrasubstituted via a DBU-mediated intramolecular cycloaddition N-alkyl propargylamines. This reaction employs dihydropyrrole intermediates, followed by oxidation produce in presence 2,3-dichloro-5,6-dicyano-p-benzoquinone. In addition, broad substrate scope, high atom economy, selectivity, and simple operation are also advantages this protocol.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10722 - 10722
Published: June 27, 2023
The use of alternative energy sources, such as microwaves (MW) or ultrasounds (US), and their mutual cross-combination have been widely described in the literature development new synthetic methodologies organic medicinal chemistry. In this review, our attention is focused on representative examples, reported year range 2013–2023 selected N-containing bicyclic heterocycles, with aim to highlight advantages microwave- ultrasound-assisted synthesis.
Language: Английский
Citations
9
RSC Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 14(12), P. 2509 - 2534
Published: Jan. 1, 2023
This review will be an essential toolbox for medicinal and bioorganic chemists seeking novel multifunctional hybrid bioactive N-heterocycles drug discovery. The work highlights the need relevance of unexplored bioisosterism employing isoquinoline-based small-molecules in design.
Language: Английский
Citations
7
Molecular Catalysis, Journal Year: 2022, Volume and Issue: 522, P. 112231 - 112231
Published: March 17, 2022
Language: Английский
Citations
9
Molecular Catalysis, Journal Year: 2022, Volume and Issue: 534, P. 112808 - 112808
Published: Nov. 18, 2022
Language: Английский
Citations
9