Molecules,
Journal Year:
2023,
Volume and Issue:
28(15), P. 5734 - 5734
Published: July 28, 2023
An
oxidant-free
and
highly
efficient
synthesis
of
phenolic
quinazolin-4(3H)-ones
was
achieved
by
simply
stirring
a
mixture
2-aminobenzamides,
sulfonyl
azides,
terminal
alkynes.
The
intermediate
N-sulfonylketenimine
underwent
two
nucleophilic
additions
the
group
eliminated
through
power
aromatization.
natural
product
2-(4-hydroxybenzyl)quinazolin-4(3H)-one
can
be
synthesized
on
large
scale
under
mild
conditions
with
this
method.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(7), P. 4199 - 4208
Published: Jan. 1, 2024
A
new
photoelectrocatalytic
mode
permits
the
synthesis
of
polycyclic
pyrimidin-4-ones
through
dehydrogenative
cyclization
malonates
with
unactivated
alkenes.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
A
Cu-catalyzed
relay
process
for
the
preparation
of
diazidated
quinazolinone
and
polycyclic
imidazole
derivatives
in
which
readily
available
alkene-tethered
substrates
undergo
an
addition/cyclization/C(sp3)–H
functionalization
alkene
sequences
with
high
efficiency
is
described.
Various
functionalized
N-heteropolycyclic
compounds
were
prepared
good
yields
a
broad
substrate
scope.
Moreover,
direct
azidation
α-C(sp3)–H
bond
corresponding
N-heterocycles
has
been
demonstrated
on
basis
mechanistic
studies,
provide
alternative
late-stage
approach
derivatization
N-heterocyclic
scaffolds.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
90(4), P. 1507 - 1513
Published: Jan. 22, 2025
A
Fe-catalyzed
hydrocyclization
reaction
of
unactivated
alkenes
was
developed,
utilizing
PhSiH3
as
the
hydrogen
source,
yielding
2,3-dihydroquinazolinone
(DHQZ)
derivatives
in
moderate
to
good
yields.
Notably,
when
substrate
switched
N-cyano-N-(2-(prop-1-en-2-yl)phenyl)benzamides,
yielded
only
unreduced
products.
Mechanistic
studies
revealed
that
intramolecular
addition
situ
formed
radical
alkene
results
formation
fused
ring.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(18), P. 12935 - 12948
Published: Sept. 6, 2023
An
electrochemical
or
photoelectrochemical
regioselective
polyfluoroalkylation/cyclization
cascade
of
3-aza-1,5-dienes
with
sodium
fluoroalkanesulfinates
is
presented.
This
protocol
proceeds
a
broad
substrate
scope
and
good
functional
group
tolerance
under
mild,
oxidant-free,
transition-metal-free,
electrolyte-free
conditions
to
provide
3-polyfluoroalkylated
4-pyrrolin-2-ones
in
one
step
from
readily
available
N-vinylacrylamides,
it
scalable
the
Gram
scale.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(16), P. 2863 - 2867
Published: April 17, 2023
CBZ6,
a
redox-neutral
non-donor-acceptor-type
organo-photocatalyst,
presents
strong
reductive
potential
with
an
oxidative
of
-2.16
V
(vs
SCE).
It
can
work
as
photosensitizer
for
both
single-electron
transfer
and
triplet
energy
processes.
This
feature
enables
site-selective
control
in
the
intramolecular
hydroarylation
acrylamides.
Both
5-exo-trig
6-endo-trig
cyclization
products
could
be
prepared
regiospecfically
under
mild
conditions.
No
transition
metal,
halogen-containing
reagents,
or
additional
reductant
oxidant
is
involved.
process
provides
concise
environmentally
sustainable
access
to
series
oxindoles
dihydroquinolinones.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(18), P. 2556 - 2559
Published: Jan. 1, 2024
3-(2-Isocyanophenyl)quinazolin-4(3
H
)-ones
were
designed
and
synthesized
as
new
building
units
for
the
construction
of
novel
quinoxalino[2,1-
b
]quinazolinones
under
mild,
photocatalytic
metal-free
conditions.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(19), P. 3585 - 3589
Published: May 8, 2023
Here,
we
report
a
photocatalytic
charge-transfer
complex
(CTC)
strategy
for
one
electron
reduction
of
alkenes
using
thiolate
as
catalytic
donor.
This
CTC
system
could
engage
hydroarylation
both
activated
and
unactivated
the
synthesis
various
heterocycles.
The
reactions
do
not
require
any
photocatalysts
or
acids
are
easy
to
perform.
Mechanistic
studies
revealed
formation
between
alkene.
