Electrochemical radical-polar crossover: a radical approach to polar chemistry

Science China Chemistry, Journal Year: 2023, Volume and Issue: 67(2), P. 450 - 470

Published: Nov. 3, 2023

Language: Английский

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Recent advances in the electrochemical synthesis of organophosphorus compounds

Beilstein Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 21, P. 770 - 797

Published: April 16, 2025

In this review, we describe recent advances in electrochemical green methods for the synthesis of various organophosphorus compounds through formation phosphorus–carbon, phosphorus–nitrogen, phosphorus–oxygen, phosphorus–sulfur, and phosphorus–selenium bonds. The impact different electrodes is also discussed matter. Graphite, platinum, RVC, nickel have been used extensively compounds. made method a promising preparing structures. This review an introduction to encourage scientists use electrosynthesis as green, precise, low-cost prepare phosphorous

Language: Английский

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Palladium-Catalyzed Aerobic Oxidative Spirocyclization of Alkyl Amides with Maleimides via β-C(sp³)–H Activation

Organic Letters, Journal Year: 2023, Volume and Issue: 25(34), P. 6305 - 6310

Published: Aug. 22, 2023

An efficient method for the synthesis of bicyclic spirodiamine molecules via β-C(sp3)–H bond activation aliphatic amides, followed by cyclization with maleimides, has been developed. The reaction proceeds through an amide-directed alkyl amides and subsequent maleimides. methodology is highly compatible a wide variety Amides derived from biologically active fatty acids were also found to be protocol. A palladacycle was synthesized intermediate in this reaction. plausible mechanism proposed account spirocyclization.

Language: Английский

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Electrochemical Synthesis of Phosphorylated Indoles and Trp-Containing Oligopeptides

Organic Letters, Journal Year: 2024, Volume and Issue: 26(22), P. 4700 - 4704

Published: May 28, 2024

Cp

Language: Английский

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Palladium-Catalysed Spiro-Cyclisation of Substituted Amino Acids with Maleimides via γ-C(sp³)–H Bond Activation

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Achieving the site-selective functionalization of unactivated C(sp3)-H bonds remains a major challenge in organic synthesis. Herein, we report an efficient method for synthesis spiro pyrrolidine molecules via γ-C(sp3)-H bond activation substituted amino acids. A variety acid and alcohol derivatives, as well dipeptides, were functionalized using this method. Also, spirocyclization optically active substrates provided potential route preparing separable diastereomers pure enantiomeric form. Moreover, some mechanistic insights have been conducted to propose feasible reaction mechanism present reaction.

Language: Английский

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Electrochemical approaches for breast cancer biomarkers: A voltammetric study of electrode potential scanning

Cell Reports Physical Science, Journal Year: 2025, Volume and Issue: unknown, P. 102569 - 102569

Published: May 1, 2025

Language: Английский

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Cp₂Fe-Mediated Electrochemical Synthesis of Phosphorylated Oxindoles and Indolo[2,1-a]isoquinolin-6(5H)-ones

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(24), P. 17521 - 17526

Published: Nov. 22, 2023

An efficient and environmentally friendly electrochemical synthesis of phosphorylated oxindoles indolo[2,1-a]isoquinolin-6(5H)-ones mediated by readily available Cp2Fe has been developed, which illustrated a broad substrate scope diverse functional group compatibility. This protocol featured an external oxidant-free process was at room temperature, proposed to be driven the anodic oxidation Cp2Fe.

Language: Английский

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Ferrocene as a Redox Catalyst for Organic Electrosynthesis

Israel Journal of Chemistry, Journal Year: 2023, Volume and Issue: 64(1-2)

Published: Aug. 23, 2023

Abstract Despite substantial advancements in thermal and photochemical catalysis, the evolution of similar processes within realm organic electrochemistry has seen a slower pace. However, recent years have heralded remarkable surge molecular electrocatalysis. This innovative technique harnesses power catalysts to expedite electrochemical transformations. article underscores application ferrocene (Fc) as redox catalyst electrosynthesis. It delves into extensive utilization Fc electrosynthesis, particularly emphasizing its role electrocatalytic generation reactions heteroatom‐ carbon‐centered radicals, among various other reactions.

Language: Английский

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Cp₂Fe‐Mediated Electrochemical Synthesis of Functionalized Compounds: Recent Advances

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(12)

Published: Feb. 29, 2024

Abstract Unlike traditional organic methods, electrosynthesis has emerged as an environmentally friendly and sustainable approach to generate a series of functionalized compounds. In this process, the traceless electron serves redox agent, eliminating need for stoichiometric oxidants or reductants. contrast direct electrolysis, redox‐mediated electrolysis ability overcome kinetic inhibitions achieve diverse selectivity under mild conditions. This garnered increasing attention from synthetic community, especially in past few years. review will focus on Cp 2 Fe‐mediated diversified compounds through C−N, C−C, C−P C−O bond formation over decade.

Language: Английский

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Selective Synthesis of Mono- and Bis-Phosphorylated (Dihydro)pyrans via TMSCl-Mediated Cascade Phosphorylation Cycloisomerization of Enynones

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

A chlorotrimethylsilane (TMSCl)-mediated cascade phosphorylation and cycloisomerization of enynones with diphenylphosphine oxides is presented. This methodology enables the highly selective synthesis monophosphorylated 2

Language: Английский

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