Organic & Biomolecular Chemistry,
Journal Year:
2021,
Volume and Issue:
19(40), P. 8706 - 8710
Published: Jan. 1, 2021
A
copper-based
catalytic
system
has
been
developed
to
enable
formal
[3
+
1
2]
annulations
of
ketoxime
acetates,
aldehydes,
and
cyanamides.
This
protocol
offers
a
new
strategy
for
the
synthesis
highly
substituted
2-aminopyrimidine
compounds,
more
importantly,
pyrimidines
have
now
included
in
N-heterocycle
family
constructed
using
O-acyl
ketoximes
as
N-C-C
synthons.
Organic Letters,
Journal Year:
2021,
Volume and Issue:
23(3), P. 936 - 942
Published: Jan. 14, 2021
A
copper-based
catalytic
system
has
been
developed
to
enable
efficient
cyclization
of
ketoxime
acetates
with
o-fluorobenzaldehydes.
This
protocol
offers
an
method
for
the
synthesis
substituted
quinoline
derivatives
a
broad
range
compatible
functionalities.
The
present
also
provides
rapid
access
synthetically
and
pharmaceutically
useful
quinoline-fused
polycycles
such
as
benzo[c]acridines.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(4), P. 1060 - 1065
Published: Jan. 26, 2022
The
first
example
of
divergent
N-heterocycle
syntheses
through
a
copper-catalyzed
three-component
reaction
α,β-unsaturated
ketoximes,
paraformaldehyde,
and
amines
has
been
documented.
In
particular,
this
synthetic
strategy
was
achieved
by
controlling
the
conditions
to
afford
corresponding
imidazoles
dihydroimidazoles
in
moderate
good
yields
with
broad
substrate
scope
functional
group
compatibility.
Organic Chemistry Frontiers,
Journal Year:
2020,
Volume and Issue:
7(15), P. 2107 - 2144
Published: Jan. 1, 2020
This
review
focuses
on
the
recent
advances
in
one-electron
oxidation
involved
oxidative
dehydrogenative
annulations
and
cyclizations
for
intermolecular
intramolecular
construction
of
valuable
ring
structures.
Organic Letters,
Journal Year:
2020,
Volume and Issue:
22(15), P. 6117 - 6121
Published: July 20, 2020
A
copper(0)/PPh3-mediated
cascade
bisheteroannulation
reaction
of
o-nitroalkynes
with
methylketoximes
has
been
developed
that
provides
viable
access
to
a
diverse
range
pyrazo-fused
pseudoindoxyl
compounds.
Synthetically
useful
functional
groups
including
sensitive
C-I
bonds
are
compatible
this
system.
Mechanistic
studies
suggest
involving
sequential
PPh3-mediated
deoxygenative
cycloisomerization
and
copper-catalyzed
[3
+
2]
pyrazo-annulation.
Chemical Communications,
Journal Year:
2020,
Volume and Issue:
56(18), P. 2807 - 2810
Published: Jan. 1, 2020
Unprecedented
direct
access
to
novel
2-diarylaminoindolo[2,3-b]indoles
via
aerobic
copper-catalyzed
[3+2]
annulation
of
diarylamines
and
indoles
is
demonstrated.
Organic Chemistry Frontiers,
Journal Year:
2020,
Volume and Issue:
7(13), P. 1635 - 1639
Published: Jan. 1, 2020
An
efficient
TFA/TBHP-promoted
oxidative
cyclisation
of
readily
available
isatins
with
1,2,3,4-tetrahydroisoquinolines
has
been
firstly
developed.
The
potential
utility
this
strategy
was
demonstrated
by
one-step
synthesis
a
natural
alkaloid
Rutaecarpin.
