Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Sept. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Language: Английский

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Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 112951 - 112951

Published: April 18, 2022

The current advancements in nanotechnology are as an outcome of the development engineered nanoparticles. Various metallic nanoparticles have been extensively explored for various biomedical applications. They attract lot attention field due to their significant inert nature, and nanoscale structures, with size similar many biological molecules. Their intrinsic characteristics which include electronic, optical, physicochemical and, surface plasmon resonance, that can be changed by altering certain particle such size, shape, environment, aspect ratio, ease synthesis functionalization properties led numerous applications fields biomedicine. These targeted drug delivery, sensing, photothermal photodynamic therapy, imaging, well modulation two or three article also discusses about cancer imaging therapeutics. associated bottlenecks related clinical translation discussed.

Language: Английский

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EMT mechanism in breast cancer metastasis and drug resistance: Revisiting molecular interactions and biological functions

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 155, P. 113774 - 113774

Published: Oct. 3, 2022

One of the malignant tumors in women that has involved both developed and developing countries is breast cancer. Similar to other types tumors, cancer cells demonstrate high metastatic nature. Besides, tumor have ability drug resistance. EMT related mechanism metastasis focus current manuscript highlighting function malignancy Breast increase their migration by induction During EMT, N-cadherin vimentin levels increase, E-cadherin decrease mediate EMT-induced invasion. Different kinds anti-cancer agents such as tamoxifen, cisplatin paclitaxel mediates chemoresistance feature cells. Furthermore, correlates with radio-resistance tumor. Clinical aspect reversing preventing chemotherapy or radiotherapy failure patients improving survival time. The anti-tumor suppress can be used for decreasing invasion increasing chemosensitivity lncRNAs, miRNAs factors modulate progression are discussed here.

Language: Английский

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(Nano)platforms in bladder cancer therapy: Challenges and opportunities

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: June 8, 2022

Urological cancers are among the most common malignancies around world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for treatment of although prognosis remains unfavorable. It is perceived that depends on an interdisciplinary approach combining biology engineering. The nanotechnological approaches introduced in various cancers, especially cancer. current review aims emphasize highlight possible applications nanomedicine eradication tumor. Nanoparticles can improve efficacy drugs therapy through elevating their bioavailability. potential genetic tools such as siRNA miRNA gene expression regulation be boosted using nanostructures by facilitating internalization accumulation at tumor sites cells. provide photodynamic photothermal ROS overgeneration hyperthermia, respectively, suppression Furthermore, remodeling microenvironment infiltration immune cells purpose immunotherapy achieved cargo-loaded nanocarriers. Nanocarriers mainly internalized endocytosis, proper design smart nanoparticles pH-, redox-, light-responsive nanocarriers importance targeted therapy. Bladder biomarkers detected timely diagnosis patients. Based site, they employed imaging. clinical translation challenges also covered review.

Language: Английский

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A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 868 - 868

Published: March 7, 2023

The new era of nanomedicine offers significant opportunities for cancer diagnostics and treatment. Magnetic nanoplatforms could be highly effective tools diagnosis treatment in the future. Due to their tunable morphologies superior properties, multifunctional magnetic nanomaterials hybrid nanostructures can designed as specific carriers drugs, imaging agents, theranostics. Multifunctional are promising theranostic agents due ability diagnose combine therapies. This review provides a comprehensive overview development advanced combining optical providing photoresponsive platforms medical applications. Moreover, this discusses various innovative developments using nanostructures, including drug delivery, treatment, tumor-specific ligands that deliver chemotherapeutics or hormonal resonance imaging, tissue engineering. Additionally, artificial intelligence (AI) used optimize material properties based on predicted interactions with cell membranes, vasculature, biological fluid, immune system enhance effectiveness therapeutic agents. Furthermore, an AI approaches assess practical utility Finally, presents current knowledge perspectives systems models.

Language: Английский

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A Comprehensive Review of Nanoparticles: From Classification to Application and Toxicity

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3482 - 3482

Published: July 25, 2024

Nanoparticles are structures that possess unique properties with high surface area-to-volume ratio. Their small size, up to 100 nm, and potential for modifications have enabled their use in a wide range of applications. Various factors influence the applications NPs, including synthesis method physical attributes such as size shape. Additionally, materials used NPs primary determinants application. Based on chosen material, generally classified into three categories: organic, inorganic, carbon-based. These categories include variety materials, proteins, polymers, metal ions, lipids derivatives, magnetic minerals, so on. Each material possesses activity application NPs. Consequently, certain typically particular areas because they higher efficiency along tenable toxicity. Therefore, classification base NP hold significant importance both research In this paper, we discuss these classifications, exemplify most major categorize them according preferred area This review provides an overall application,

Language: Английский

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Cancer therapy by nano MIL-n series of metal-organic frameworks

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 503, P. 215643 - 215643

Published: Jan. 8, 2024

Language: Английский

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Curcumin loaded β-cyclodextrin-magnetic graphene oxide nanoparticles decorated with folic acid receptors as a new theranostic agent to improve prostate cancer treatment

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 340, P. 122328 - 122328

Published: May 26, 2024

Language: Английский

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Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: May 28, 2022

Abstract A proper self‐regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated cardiovascular disorders makes engineering critical. Novel approaches are now being investigated order to speedily overcome challenges this path. Tissue has been revolutionized by advent nanomaterials, and later application carbon‐based nanomaterials because their exceptional variable functionality, conductivity, mechanical properties. Electrically conductive biomaterials used as cell bearers provide an appropriate microenvironment for specific seeded cells substrates sake protecting biological media against attacking mechanisms. Nevertheless, advantages shortcoming view cellular behavior, toxicity, targeted delivery depend on they implanted or a scaffold. This review seeks address, summarize, classify, conceptualize, discuss use nanoparticles emphasizing conductivity. We considered electrical conductivity key affecting regeneration cells. Correspondingly, we reviewed polymers specifically repair high efficiency. comprehensively classified discussed using engineering. An overall open literature electroactive including over last decade was provided, tabulated, thoroughly discussed. The most commonly comprising graphene, graphene oxide, carbon nanotubes, nanofibers were studied.

Language: Английский

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Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: Sept. 13, 2022

Green chemistry has been a growing multidisciplinary field in recent years showing great promise biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and present insects fungi. This polysaccharide favorable characteristics, including biocompatibility, biodegradability, ease of modification by enzymes chemicals. CS-based nanoparticles (CS-NPs) have shown potential the treatment other diseases, affording targeted delivery overcoming drug resistance. The current review emphasizes on application CS-NPs chemotherapeutic agent, doxorubicin (DOX), therapy as they promote internalization DOX cells prevent activity P-glycoprotein (P-gp) to reverse These nanoarchitectures can provide co-delivery with antitumor agents such curcumin cisplatin induce synergistic Furthermore, co-loading siRNA, shRNA, miRNA suppress tumor progression chemosensitivity. Various nanostructures, lipid-, carbon-, polymeric- metal-based nanoparticles, are modifiable CS delivery, while functionalization ligands hyaluronic acid promotes selectivity toward prevents demonstrate high encapsulation efficiency due protonation amine groups CS, pH-sensitive release occur. redox- light-responsive prepared treatment. Leveraging these characteristics view biocompatibility CS-NPs, we expect soon see significant progress towards clinical translation.

Language: Английский

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