Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(18), P. 8137 - 8137
Published: Sept. 10, 2024
Biofilm-associated
infections
present
a
significant
challenge
in
modern
medicine,
primarily
due
to
their
resilience
and
resistance
conventional
treatments.
These
occur
when
bacteria
form
biofilms,
protective
layers
formed
by
bacterial
communities,
which
are
notoriously
resistant
traditional
antibiotics
on
surfaces
such
as
medical
implants
biological
surfaces,
making
eradication
with
standard
difficult.
This
leads
persistent
infections,
imposing
substantial
economic
burden
healthcare
systems.
The
urgency
find
alternative
treatments
is
critical
current
methods
insufficient
costly.
Innovative
approaches,
nanotechnology-based
therapies,
offer
promising
alternatives
targeting
biofilms
more
effectively
reducing
the
need
for
invasive
procedures.
Nanocarriers
hold
promise
fight
against
biofilm-associated
infections.
can
penetrate
than
treatments,
delivering
higher
concentrations
of
or
other
antimicrobial
agents
precisely
where
they
needed.
targeted
approach
not
only
enhances
efficacy
but
also
minimizes
potential
side
effects.
development
nanocarrier-based
therapies
crucial
overcoming
limitations
ultimately
improving
patient
outcomes
In
this
review,
systems,
characteristics,
limitations,
benefits
explored
address
biofilms-related
Additionally,
biofilm
evaluation
models
tests
necessary
preclinical
validation
these
nanosystems
facilitate
clinical
application
addressed.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(17)
Published: Jan. 31, 2023
Antimicrobial
resistance
(AMR)
is
one
of
the
biggest
threats
to
environment
and
health.
AMR
rapidly
invalidates
conventional
antibiotics,
antimicrobial
nanomaterials
have
been
increasingly
explored
as
alternatives.
Interestingly,
several
show
AMR-independent
effects
without
detectable
new
therefore
suggested
prevent
evolution.
In
contrast,
some
are
found
trigger
evolution
AMR.
Given
these
seemingly
conflicting
findings,
a
timely
discussion
two
faces
urgently
needed.
This
review
systematically
compares
killing
mechanisms
structure-activity
relationships
antibiotics
nanomaterials.
We
then
focus
on
nano-microbe
interactions
elucidate
impacts
molecular
initiating
events
Finally,
we
provide
an
outlook
future
propose
design
principles
for
prevention
Catalysts,
Journal Year:
2023,
Volume and Issue:
13(4), P. 642 - 642
Published: March 23, 2023
Magnesium
oxide
nanoparticles
(MgO
NPs)
have
emerged
as
potential
materials
for
various
biomedical
applications
due
to
their
unique
physicochemical
properties,
including
biodegradability,
biocompatibility,
cationic
capacity,
high
stability
and
redox
properties.
MgO
NPs
become
an
attractive
platform
combat
microbes
may
be
a
promising
alternative
overcome
challenges
associated
with
eliminating
microbial
biofilms
antibiotic
resistance.
Hence,
the
increasing
use
of
in
biomedicine,
new
synthetic
strategies
are
necessary.
synthesised
using
green
methods
non-toxic,
eco-friendly
wide
range
biological,
medical
catalytic
applications.
This
review
presents
recent
advances
biosynthesis
by
diverse
bio-templates,
such
plant,
bacterial,
fungal
algal
extracts.
Its
photocatalytic
properties
show
suitable
inhibitory
function
against
pathogenic
agents,
proliferation,
biofilm
formation
growth.
Furthermore,
relevant
nanocomposites
comprehensively
discussed
regarding
mechanisms
effect
on
microbes,
strains,
well
future
perspectives.
Biomedical Microdevices,
Journal Year:
2024,
Volume and Issue:
26(1)
Published: Jan. 23, 2024
Abstract
The
rise
in
drug
resistance
pathogenic
bacteria
greatly
endangers
public
health
the
post-antibiotic
era,
and
drug-resistant
currently
pose
a
great
challenge
not
only
to
community
but
also
clinical
procedures,
including
surgery,
stent
implantation,
organ
transplantation,
other
medical
procedures
involving
any
open
wound
compromised
human
immunity.
Biofilm-associated
failure,
as
well
rapid
last-resort
antibiotics,
necessitates
search
for
novel
treatments
against
bacterial
infection.
In
recent
years,
flourishing
development
of
nanotechnology
has
provided
new
insights
exploiting
promising
alternative
therapeutics
bacteria.
Metallic
agents
have
been
applied
antibacterial
usage
several
centuries,
functional
modification
metal-based
biomaterials
using
now
attracted
interest
field,
their
intrinsic
nature
ready
on-demand
functionalization
enhanced
interaction
with
bacteria,
rendering
them
good
potential
further
translation.
However,
possible
toxicity
MNPs
host
cells
tissue
still
hinders
its
application,
current
knowledge
on
cellular
pathways
is
enough.
This
review
will
focus
advances
developing
metallic
nanoparticles
(MNPs),
silver,
gold,
copper,
nanoparticles,
applications,
mechanisms
hosts.
RSC Advances,
Journal Year:
2022,
Volume and Issue:
12(45), P. 29078 - 29102
Published: Jan. 1, 2022
Antibiotic
resistance
is
one
of
the
critical
issues,
describing
a
significant
social
health
complication
globally.
Hence,
discovery
novel
antibiotics
has
acquired
an
increased
attention
particularly
against
drug-resistant
pathogens.
Natural
products
have
served
as
potent
therapeutics
pathogenic
bacteria
since
glorious
age
mid
20th
century.
This
review
outlines
various
mechanistic
candidates
for
dealing
with
multi-drug
resistant
pathogens
and
explores
terrestrial
phytochemicals
isolated
from
plants,
lichens,
insects,
animals,
fungi,
bacteria,
mushrooms,
minerals
reported
antimicrobial
activity,
either
alone
or
in
combination
conventional
antibiotics.
Moreover,
newly
established
tools
are
presented,
including
prebiotics,
probiotics,
synbiotics,
bacteriophages,
nanoparticles,
bacteriocins,
supporting
progress
effective
to
address
emergence
antibiotic-resistant
infectious
bacteria.
Therefore,
current
article
may
uncover
promising
drug
that
can
be
used
future.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(2), P. 657 - 676
Published: Jan. 19, 2024
The
fusion
of
MXene-based
materials
with
microfluidics
not
only
presents
a
dynamic
and
promising
avenue
for
innovation
but
also
opens
up
new
possibilities
across
various
scientific
technological
domains.
This
Perspective
delves
into
the
intricate
synergy
between
MXenes
microfluidics,
underscoring
their
collective
potential
in
material
science,
sensing,
energy
storage,
biomedical
research.
intersection
disciplines
anticipates
future
advancements
MXene
synthesis
functionalization
as
well
progress
advanced
sensing
technologies,
storage
solutions,
environmental
applications,
breakthroughs.
Crucially,
manufacturing
commercialization
microfluidic
devices,
coupled
interdisciplinary
collaborations,
stand
pivotal
considerations.
Envisioning
where
collaboratively
shape
our
landscape,
addressing
challenges
propelling
forward
necessitates
thoughtful
approach.
viewpoint
provides
comprehensive
assessment
current
state
field
while
outlining
prospects
integration
entities
microfluidics.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 3187 - 3215
Published: April 1, 2024
Abstract:
Green
synthesis
of
silver
(Ag)
and
gold
(Au)
nanoparticles
(NPs)
has
acquired
huge
popularity
owing
to
their
potential
applications
in
various
fields.
A
large
number
research
articles
exist
the
literature
describing
green
Ag
Au
NPs
for
biomedical
applications.
However,
these
findings
are
scattered,
making
it
time-consuming
researchers
locate
promising
advancements
unexplored
Unlike
other
review
articles,
this
systematic
study
not
only
highlights
recent
but
also
explores
The
article
discusses
approaches
highlighting
emerging
developments
novel
strategies.
Then,
reviews
important
synthesized
by
critically
evaluating
expected
advantages.
To
expose
future
direction
field,
describes
NPs.
Finally,
discuss
challenges
limitations
This
will
serve
as
a
valuable
reference
researchers,
working
on
Keywords:
nanoparticles,
environmental-friendly,
applications,
potentials
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(9), P. 1134 - 1134
Published: Aug. 29, 2024
The
increasing
threat
from
antibiotic-resistant
bacteria
has
necessitated
the
development
of
novel
methods
to
counter
bacterial
infections.
In
this
context,
application
metallic
nanoparticles
(NPs),
especially
gold
(Au)
and
silver
(Ag),
emerged
as
a
promising
strategy
due
their
remarkable
antibacterial
properties.
This
review
examines
research
published
between
2006
2023,
focusing
on
leading
journals
in
nanotechnology,
materials
science,
biomedical
research.
primary
applications
explored
are
efficacy
Ag
Au
NPs
agents,
synthesis
methods,
morphological
properties,
mechanisms
action.
An
extensive
literature
synthesis,
morphology,
minimum
inhibitory
concentration
(MIC),
bactericidal
(MBC),
effectiveness
against
various
Gram(+/-)
confirms
NPs.
characteristics
NPs,
such
size,
shape,
surface
charge,
crucial
determining
activity,
these
factors
influence
interactions
with
cells.
Furthermore,
underscores
urgent
necessity
standardizing
techniques,
MICs,
reporting
protocols
enhance
comparability
reproducibility
future
studies.
Standardization
is
essential
for
ensuring
reliability
findings
accelerating
clinical
NP-based
antimicrobial
approaches.
aims
propel
strategies
by
elucidating
properties
that
activity
By
highlighting
effects
strains
relatively
low
cytotoxicity,
work
positions
developing
making
significant
contribution
global
efforts
combat
pathogens.
