Materials Today Physics, Journal Year: 2022, Volume and Issue: 30, P. 100925 - 100925
Published: Nov. 21, 2022
Language: Английский
Journal of Molecular Liquids, Journal Year: 2021, Volume and Issue: 347, P. 118160 - 118160
Published: Dec. 1, 2021
The combination of water and surface-active ionic liquids provides a unique reaction medium, facilitating aggregation micellization the liquid to allow for chemical reactions in bulk water. With growing focus on sustainable technologies, have emerged as tunable solvents multiple applications but are often too viscous or expensive use solvent. As result, there has been tremendous increase interest behavior presence It already shown that certain act surfactants aqueous solutions, enabling both afford solvent systems with properties. Ultimately, give rise distinct chemistry their own compared traditional molecular solvents, thus is rapidly growing. In this review, general structure key features micellar structures discussed. Furthermore, characterization techniques formed micelles presented, discussing possible methods studying behavior. Finally, current across all fields chemistry, from organic nanoparticle synthesis presented.
Language: Английский
Citations
182
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(20), P. 7262 - 7293
Published: Jan. 1, 2023
This review highlights the recent advances and emerging opportunities of ionic liquids in biomedicine based on their intrinsic advantages potentials.
Language: Английский
Citations
42
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(1), P. 151 - 151
Published: Jan. 22, 2024
The unique properties of ionic liquids (ILs), such as structural tunability, good solubility, chemical/thermal stability, favorable biocompatibility, and simplicity preparation, have led to a wide range applications in the pharmaceutical biomedical fields. ILs can not only speed up chemical reaction process, improve yield, reduce environmental pollution but also many problems field medicine, poor drug product crystal instability, biological activity, low delivery efficiency. This paper presents systematic concise analysis recent advancements further from aspects synthesis, analysis, solubilization, engineering. Additionally, it explores field, covering carriers, stabilization proteins, antimicrobials, bioactive liquids.
Language: Английский
Citations
34
ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(36), P. 42461 - 42472
Published: Aug. 30, 2021
Since injection administration for diabetes is invasive, it important to develop an effective transdermal method insulin. However, delivery remains challenging owing the strong barrier function of stratum corneum (SC) skin. Here, we developed ionic liquid (IL)-in-oil microemulsion formulations (MEFs) insulin using choline–fatty acids ([Chl][FAs])—comprising three different FAs (C18:0, C18:1, and C18:2)—as biocompatible surface-active ILs (SAILs). The MEFs were successfully [Chl][FAs] as surfactants, sorbitan monolaurate (Span-20) a cosurfactant, choline propionate IL internal polar phase, isopropyl myristate continuous oil phase. Ternary phase behavior, dynamic light scattering, transmission electron microscopy studies revealed that thermodynamically stable with nanoparticle size. significantly enhanced permeation via intercellular route by compromising tight lamellar structure SC lipids through fluidity-enhancing mechanism. In vivo low doses (50 IU/kg) diabetic mice showed reduced blood glucose levels (BGLs) compared commercial surfactant-based formulation increasing bioavailability in systemic circulation sustained level much longer period (half-life > 24 h) than subcutaneous 1.32 h). When [Chl][C18:2] SAIL-based MEF was transdermally administered, BGL 56% its initial value. nontoxic (cell viability 90%). They remained at room temperature 3 months their biological activity retained 4 °C. We believe will alter current approaches therapy may be potential nanocarrier protein peptide delivery.
Language: Английский
Citations
68
Journal of Molecular Liquids, Journal Year: 2022, Volume and Issue: 351, P. 118643 - 118643
Published: Jan. 31, 2022
Language: Английский
Citations
48
Pharmaceutical Research, Journal Year: 2022, Volume and Issue: 39(10), P. 2367 - 2377
Published: June 23, 2022
Language: Английский
Citations
48
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1179 - 1179
Published: April 7, 2023
The development of effective drug formulations and delivery systems for newly developed or marketed molecules remains a significant challenge. These drugs can exhibit polymorphic conversion, poor bioavailability, systemic toxicity, be difficult to formulate with traditional organic solvents due acute toxicity. Ionic liquids (ILs) are recognized as that improve the pharmacokinetic pharmacodynamic properties drugs. ILs address operational/functional challenges associated solvents. However, many non-biodegradable inherently toxic, which is most challenge in developing IL-based systems. Biocompatible comprising biocompatible cations anions mainly derived from bio-renewable sources considered green alternative both conventional organic/inorganic This review covers technologies strategies design ILs, focusing on systems, discusses advantages these pharmaceutical biomedical applications. Furthermore, this will provide guidance transitioning rather than commonly used toxic fields ranging chemical synthesis pharmaceutics.
Language: Английский
Citations
33
Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1124 - 1124
Published: April 7, 2023
Nano-engineered medical products first appeared in the last decade. The current research this area focuses on developing safe drugs with minimal adverse effects associated pharmacologically active cargo. Transdermal drug delivery, an alternative to oral administration, offers patient convenience, avoids first-pass hepatic metabolism, provides local targeting, and reduces effective toxicities. Nanomaterials provide alternatives conventional transdermal delivery including patches, gels, sprays, lotions, but it is crucial understand transport mechanisms involved. This article reviews recent trends emphasizes nano-formulations currently vogue.
Language: Английский
Citations
30
Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 331, P. 103244 - 103244
Published: June 26, 2024
Ionic liquids (ILs) play a crucial role in the design of novel materials. The ionic nature ILs provides numerous advantages drug delivery, acting as green solvent or active ingredient to enhance solubility, permeability, and binding efficiency drugs. They could also function structuring agent development nano/micro particles for including micelles, vesicles, gels, emulsion, more. This review summarize IL-based gel structures with their advanced delivery applications. first part focuses on formulation applications delivery. second offers comprehensive overview recent gel. It aims offer new perspectives attract more attention open up avenues biomedical gels.
Language: Английский
Citations
14
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716
Published: Sept. 2, 2024
About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.
Language: Английский
Citations
14