A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice DOI
Zhiwei Li, Guodong Zheng,

Na Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(6), P. 2883 - 2897

Published: Feb. 1, 2023

Aβ aggregation-related neuroinflammation and imbalance of brain glucose homeostasis play important roles in the pathological process Alzheimer's disease (AD). Chlorogenic acid (CGA) is one most common dietary polyphenols with neuroprotective effects. However, due to low bioavailability CGA, its application dose usually high vivo. In our previous study, spherical selenium nanoparticles act as drug carriers improve bioactivity resveratrol. Here, brain-targeting peptide (TGN peptide) CGA were used prepare a new flowerlike nanocluster (TGN-CGA@SeNCs) for enhancing CGA. After decoration on nanoclusters, solubility stability was obviously increased. Oral administration (80 mg/kg/body weight) only slightly inhibited aggregate-related disorder brain. Moreover, showed less effect increasing diversity richness gut microbiota. At same concentration, CGA-modified (CGA@SeNCs) TGN-CGA@SeNCs better function ameliorating microbiota disorder. Especially, significantly increased relative abundance Turicibacter, Colidextribacter, Ruminococcus, Alloprevotella, Alistipes against oxidative stress, inflammation, imbalance. Notably, can transport through blood-brain barrier (BBB), effects than CGA@SeNCs regulating aggregation improving homeostasis. These results broadened TGN-CGA@SeNCs, effectively which also lowers preventing AD progression.

Language: Английский

Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases DOI
Yueqin Li, Yao Peng,

Yingbin Shen

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(29), P. 9816 - 9842

Published: May 19, 2022

Advanced glycation end products (AGEs) are formed in non-enzymatic reaction, oxidation, rearrangement and cross-linking between the active carbonyl groups of reducing sugars free amines amino acids. The Maillard reaction is related to sensory characteristics thermal processed food, while AGEs food matrix this process. a key link stress neurodegenerative disease. can interact with receptors for (RAGE), causing oxidative stress, inflammation response signal pathways activation diseases. Neurodegenerative diseases closely gut microbiota imbalance intestinal inflammation. Polyphenols multiple hydroxyl showed powerful ability scavenge ROS capture α-dicarbonyl species, which led formation mono- di- adducts, thereby inhibiting formation. be effectively prevented by production, interaction RAGEs, or regulating microbiota-gut-brain axis. These strategies include polyphenols multifunctional effects on inhibition, RAGE-ligand interactions blocking, abundance diversity microbiota, alleviation delay prevent progress. It wise promising strategy supplement dietary preventing via AGEs-RAGE axis regulation.

Language: Английский

Citations

103
Orally deliverable sequence-targeted astaxanthin nanoparticles for colitis alleviation DOI
Yannan Chen, Wentao Su, Shanshan Tie

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 293, P. 121976 - 121976

Published: Dec. 22, 2022

Language: Английский

Citations

84
The gut-brain vascular axis in neuroinflammation DOI Creative Commons
Sara Carloni, María Rescigno

Seminars in Immunology, Journal Year: 2023, Volume and Issue: 69, P. 101802 - 101802

Published: July 7, 2023

The multifaceted microbiota characterizing our gut plays a crucial role in maintaining immune, metabolic and tissue homeostasis of the intestine as well distal organs, including central nervous system. Microbial dysbiosis is reported several inflammatory intestinal diseases characterized by impairment epithelial vascular barriers, defined leaky gut, it potential danger condition associated with development metabolic, neurodegenerative diseases. Recently, we pointed out strict connection between brain via novel axis. Here want to deepen knowledge on gut-brain axis, particular emphasis microbial dysbiosis, cerebral firm association axis will be summarized context protection, amelioration or boosting Alzheimer, Parkinson, Major depressive Anxiety disorders. Understanding relationship disease pathophysiology, mucosal barrier function host-microbe interaction foster use microbiome biomarker for health target therapeutic nutritional advances.

Language: Английский

Citations

59
Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer's disease DOI
Licong Yang, Yabin Wang, Zhiwei Li

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 310, P. 120714 - 120714

Published: Feb. 18, 2023

Language: Английский

Citations

48
Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response DOI Creative Commons

Mohammad Ajmal

Diseases, Journal Year: 2023, Volume and Issue: 11(1), P. 30 - 30

Published: Feb. 9, 2023

Proteins are central to life functions. Alterations in the structure of proteins reflected their function. Misfolded and aggregates present a significant risk cell. Cells have diverse but integrated network protection mechanisms. Streams misfolded that cells continuously exposed must be continually monitored by an elaborated molecular chaperones protein degradation factors control contain misfolding problems. Aggregation inhibition properties small molecules such as polyphenols important they possess other beneficial antioxidative, anti-inflammatory, pro-autophagic help neuroprotection. A candidate with desired features is for any possible treatment development aggregation diseases. There need study phenomenon so we can treat some worst kinds human ailments related aggregation.

Language: Английский

Citations

46
Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders DOI Creative Commons
Maria Scuto,

Francesco Rampulla,

Giuseppe Maria Reali

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 484 - 484

Published: April 18, 2024

The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest preventing therapeutically impacting neuropathologies gastrointestinal diseases. Polyphenols polyphenol-combined nanoparticles in synergy with probiotics shown to improve gut bioavailability blood-brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic dysfunction inflammation linked dysbiosis ultimately onset progression central nervous system (CNS) disorders. In accordance hormesis, polyphenols display biphasic dose-response by activating at a low dose Nrf2 pathway resulting upregulation

Language: Английский

Citations

29
Mannose-Integrated Nanoparticle Hitchhike Glucose Transporter 1 Recycling to Overcome Various Barriers of Oral Delivery for Alzheimer’s Disease Therapy DOI
Ting Lei, Zixiao Yang,

Chaoqing Jiang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3234 - 3250

Published: Jan. 12, 2024

A brain-targeting nanodelivery system has been a hot topic and undergone rapid progression. However, due to various obstacles such as the intestinal epithelial barrier (IEB) blood-brain (BBB), few nanocarriers can achieve through oral administration. Herein, an intelligent nanoparticle (FTY@Man NP) constructed from PLGA-PEG skeleton loaded with fingolimod (FTY) externally modified mannose was designed in combination glucose control strategy for multitarget treatment of Alzheimer's disease (AD). The hydrophilic electronegative properties facilitated its facile penetration mucus barrier, while ligand conferred IEB targeting abilities nanoparticle. Subsequently, glycemic allowed mannose-integrated hitchhike transporter 1 (GLUT1) circulation across BBB. Finally, released FTY modulated polarity microglia pro-inflammatory M1 anti-inflammatory M2 normalized activated astrocyte, enhancing clearance toxic protein Amyloid-β (Aβ) alleviating oxidative stress neuroinflammation. Notably, both vitro vivo results have consistently demonstrated that administration FTY@Man NP could effectively traverse multiple barriers, thereby exerting significant therapeutic effects. This breakthrough holds promise realizing highly effective orally administered AD.

Language: Английский

Citations

25
Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge DOI Open Access
Magdalena Tyczyńska,

Marta Gędek,

Adam Brachet

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(8), P. 2381 - 2381

Published: April 19, 2024

Changes in trace element concentrations are being wildly considered when it comes to neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. This study aims present the role that elements play central nervous system. Moreover, we reviewed mechanisms involved their neurotoxicity. Low zinc concentrations, well high levels of copper, manganese, iron, activate signalling pathways inflammatory, oxidative nitrosative stress response. Neurodegeneration occurs due association between metals proteins, which is then followed by aggregate formation, mitochondrial disorder, and, ultimately, cell death. In disease, low Zn suppress neurotoxicity induced β-amyloid through selective precipitation aggregation intermediates. High iron manganese cause intracellular α-synuclein, results synaptic dysfunction axonal transport disruption. caused accumulation Fe midbrain dopaminergic nucleus, pathogenesis multiple sclerosis derives from deficiency, leading an imbalance T functions. Aluminium disturbs homeostasis other a rise production oxygen reactive forms, leads cellular Selenium, with plays distinct process ferroptosis. Outlining influence have on oxidoreduction processes crucial recognising pathophysiology diseases may provide possible new methods for both avoidance therapy.

Language: Английский

Citations

19
Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases DOI Creative Commons

Yun Dai,

Yifan Guo,

Weicheng Tang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 15, 2024

With increasing proportion of the elderly in population, age-related diseases (ARD) lead to a considerable healthcare burden society. Prevention and treatment ARD can decrease negative impact aging disease. The rate is closely associated with production high levels reactive oxygen species (ROS). ROS-mediated oxidative stress triggers aging-related changes through lipid peroxidation, protein oxidation, DNA oxidation. Antioxidants control autoxidation by scavenging free radicals or inhibiting their formation, thereby reducing stress. Benefiting from significant advances nanotechnology, large number nanomaterials ROS-scavenging capabilities have been developed. be divided into two categories: as carriers for delivering drugs, themselves activity. This study summarizes current prevention ARD, highlights potential mechanisms used discusses challenges prospects applications.

Language: Английский

Citations

17
The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases DOI Open Access
Yuan Zhang, Wanpeng Yu, Lei Zhang

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(24), P. 5373 - 5373

Published: Dec. 17, 2022

Polyphenols are secondary metabolites of plants and play a potential role in the prevention treatment neurodegenerative diseases (NND) such as Alzheimer’s disease (AD) Parkinson’s (PD) due to their unique physiological functions acting antioxidants, being anti-inflammatory, neuroprotective, promoting intestinal health. Since dietary polyphenols exist plant foods form glycosylation or esterification combined with polymers, they need undergo extensive metabolism through phase I II biotransformations by various enzymes, well microbiota before can be fully absorbed. improve disorders influencing structure function microbiota, inducing beneficial bacteria produce variety short-chain fatty acids (SCFAs), secretion hormones neurotransmitters, playing an important NND affecting microbe–gut–brain axis. We review ways which some change composition AD PD animal models exert slowing down progression NND, aiming provide evidence for via microbiota–gut–brain (MGB)

Language: Английский

Citations

49