Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 30, 2023

Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation of inflammatory responses associated with most human diseases. Reactive oxygen species (ROS) are class chemicals that generated after incomplete reduction molecular oxygen. At moderate levels, ROS function as critical signaling molecules in modulation various physiological functions, including responses. However, at excessive exert toxic effects and directly oxidize biological macromolecules, such proteins, nucleic acids lipids, further exacerbating development causing Therefore, designing manufacturing biomaterials scavenge has emerged an important approach for restoring homeostasis, limiting protecting host against damage. This review systematically outlines dynamic balance production clearance under conditions. We focus on mechanisms by which regulate cell proteins how these affect inflammation. Furthermore, we discuss use potential currently available-biomaterials ROS, agents were engineered reduce levels blocking generation, chemically reacting or catalytically accelerating clearance, treatment Finally, evaluate challenges prospects controlled material design scavenging biomaterials.

Language: Английский

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Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100582 - 100582

Published: Feb. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Language: Английский

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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: Aug. 22, 2023

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating due to their excellent hydrophilicity, good drug-loading ability sustained drug release properties. As typical example, hyaluronic acid dressing (Healoderm) has been demonstrated clinical trials improve wound-healing efficiency healing rates foot ulcers. However, the degradation behavior clinically-used cannot adjusted according microenvironment. Due intricacy wounds, antibiotics other medications are frequently combined with practice, although these easily hindered by hostile environment. In this case, scientists created responsive-hydrogel based on microenvironment features (such as high glucose low pH) or external stimuli light magnetic field) achieve controllable release, gel degradation, improvements order overcome issues. These anticipated play significant role therapeutic dressings. Here, we review recent advances towards healing, focus structure design, principle responsiveness, degradation. Last but not least, advantages limitations responsive-hydrogels applications will also discussed. We hope contribute furthering progress hydrogels improved practical application.

Language: Английский

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Research progress of polyphenols in nanoformulations for antibacterial application

Materials Today Bio, Journal Year: 2023, Volume and Issue: 21, P. 100729 - 100729

Published: July 11, 2023

Infectious disease is one of the top 10 causes death worldwide, especially in low-income countries. The extensive use antibiotics has led to an increase antibiotic resistance, which poses a critical threat human health globally. Natural products such as polyphenolic compounds and their derivatives have been shown positive therapeutic effects antibacterial therapy. However, inherent physicochemical properties limit pharmaceutical effects, short half-lives, chemical instability, low bioavailability, poor water solubility. Nanoformulations promising advantages improving activity by controlling release drugs enhancing bioavailability polyphenols. In this review, we listed classification mechanisms compounds. More importantly, nanoformulations for delivery polyphenols agent were summarized, including different types nanoparticles (NPs) polymer-based NPs, metal-based lipid-based nanoscaffolds nanogels, nanofibers, nanoemulsions. At same time, also presented potential biological applications nano-system enhance ability polyphenols, aiming provide new perspective antibiotic-free treatment infectious diseases.

Language: Английский

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Dual Glucose/ROS-Sensitive Injectable Adhesive Self-Healing Hydrogel with Photothermal Antibacterial Activity and Modulation of Macrophage Polarization for Infected Diabetic Wound Healing

ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(12), P. 3142 - 3155

Published: Oct. 27, 2023

Antibacterial, anti-inflammatory, and healing-promoting treatment of chronically infected wounds is not only clinical problems to be solved urgently but also important needs related people's livelihood. However, multifunctional hydrogel dressings with highly efficient antibacterial, wound microenvironment sensitive drug release performance still remain a challenge. In this work, dressing was achieved by introducing mussel-like super adhesion catechol groups glucose/ROS-sensitive dynamic phenylboronester bond cross-linking network, which endowed the excellent injectable, self-healing, tissue properties, performance. Additionally, high-efficiency photothermal synergistic antibacterial TP@Ag NPs were prepared introduced into hydrogel. The glucose/ROS responsive borate in network could realize NPs, thereby promoting M2 polarization achieve an anti-inflammatory effect. And excess reactive oxygen (ROS) scavenged effect group ROS-sensitive Moreover, biocompatibility antioxidant shown hydrogels. Finally, fully fill adhere irregular through injection significantly promote diabetic healing vivo sterilization, ROS scavenging ability, modulation macrophage reduce inflammatory response. Thus, it illustrated superiority as advanced functional for healing.

Language: Английский

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Hydrogel-based dressings designed to facilitate wound healing

Materials Advances, Journal Year: 2023, Volume and Issue: 5(4), P. 1364 - 1394

Published: Dec. 20, 2023

This review provides an overview of the functionalities hydrogel-based dressings and their role in promoting wound healing.

Language: Английский

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Tough adhesion enhancing strategies for injectable hydrogel adhesives in biomedical applications

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 319, P. 102982 - 102982

Published: Aug. 13, 2023

Language: Английский

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Thiourea‐Cation Chelation Based Hydrogel and its Application as Antibacterial Dressing for the Repair of Diabetic Wound

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(22)

Published: Feb. 2, 2024

Abstract For various chronic wounds, bacterial infection is one of the important reasons that hinder their healing. Ion‐crosslinked antibacterial hydrogel dressings based on Ag + , Cu 2+ and Zn have made progress in clinical application. However, toxicity released metal ions cannot be ignored. Therefore, how to ensure performance dressing while reducing amount a major challenge for fabrication ion hydrogel. In this study, general method proposed design cationic ion‐crosslinked thiourea groups. Taking formed by mixing modified hyaluronic acid (H‐ANCSN) with (HA‐NCSN/Ag hydrogel) as an example, characteristics application potential kind are thoroughly explored. Due strong chelation groups, HA‐NCSN/Ag can gel at low concentration achieve long‐term slow release stable balance biocompatible properties. Moreover, dynamic thiourea‐Ag crosslinking also endowed property “gelation encapsulation first, injection cover wound when necessary”. Then, mangiferin self‐assembled nanoparticles loaded into radical oxygen species scavenger.

Language: Английский

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All‐in‐One Self‐Powered Microneedle Device for Accelerating Infected Diabetic Wound Repair

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Feb. 7, 2024

Abstract Diabetic wound healing remains a significant clinical challenge due to the complex microenvironment and attenuated endogenous electric field. Herein, novel all‐in‐one self‐powered microneedle device (termed TZ@mMN‐TENG) is developed by combining multifunctional carried tannin@ZnO microparticles (TZ@mMN) with triboelectric nanogenerator (TENG). In addition delivery of tannin Zn 2+ , TZ@mMN also effectively conducts electrical stimulation (ES) infected diabetic wounds. As device, TENG can convert biomechanical motion into exogenous ES accelerate healing. vitro experiment demonstrated that shows excellent conductive, high antioxidant ability, effective antibacterial properties against both Staphylococcus aureus Escherichia coli (>99% rates). Besides, TZ@mMN‐TENG promote cell proliferation migration. rat full‐thickness skin model eliminate bacteria, epidermal growth (regenerative epidermis: ≈303.3 ± 19.1 µm), enhance collagen deposition, inhibit inflammation (lower TNF‐α IL‐6 expression), angiogenesis (higher CD31 VEGF expression) repair. Overall, provides promising strategy for application in

Language: Английский

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Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

Materials, Journal Year: 2024, Volume and Issue: 17(2), P. 278 - 278

Published: Jan. 5, 2024

Effective wound treatment has become one of the most important challenges for healthcare as it continues to be leading causes death worldwide. Therefore, care technologies significantly evolved in order provide a holistic approach based on various designs functional dressings. Among them, hydrogels have been widely used due their biocompatibility and similarity extracellular matrix. The hydrogel formula offers control an optimal moisture level its ability absorb excess fluid from or release needed. Additionally, can successfully integrated with plethora biologically active components (e.g., nanoparticles, pharmaceuticals, natural extracts, peptides), thus enhancing performance resulting composite healing applications. In this review, the-state-of-the-art discoveries related stimuli-responsive hydrogel-based dressings summarized, taking into account antimicrobial, anti-inflammatory, antioxidant, hemostatic properties, well other effects re-epithelialization, vascularization, restoration tissue) use.

Language: Английский

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