Natural dietary ROS scavenger-based nanomaterials for ROS-related chronic disease prevention and treatment

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151756 - 151756

Published: April 30, 2024

Language: Английский

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Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications

Discover Materials, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 9, 2025

Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.

Language: Английский

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New Perspectives of Hydrogels in Chronic Wound Management

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 686 - 686

Published: Feb. 4, 2025

Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents detailed overview of chronic emphasizes the critical need for novel therapeutic solutions. The pathophysiology wound healing is discussed, including stages factors contributing chronicity. focus on diverse types wounds, such as diabetic foot necrosis, pressure ulcers, venous leg highlighting etiology, consequences, issues they provide. Further, modern care solutions, particularly hydrogels, are highlighted tackling challenges management. Hydrogels characterized multipurpose materials that possess vital characteristics like capacity retain moisture, biocompatibility, incorporation active drugs. Hydrogels’ effectiveness in applications demonstrated by how support healing, preserving ideal moisture levels, promoting cellular migration, possessing antibacterial properties. Thus, this hydrogel technology’s latest developments, emphasizing drug-loaded stimuli-responsive underscoring these advanced formulations greatly improve therapy outcomes enabling dynamic focused reactions environment. Future directions research promote development customized treatments digital health tools treatment wounds.

Language: Английский

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Antimicrobial Phenolic Materials: From Assembly to Function

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.

Language: Английский

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Recent advances in tannic acid-based gels: Design, properties, and applications

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 339, P. 103425 - 103425

Published: Feb. 15, 2025

Language: Английский

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Stimuli-responsive hydrogel dressing for wound healing

APL Materials, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

Wound healing is a complex, variable, and time-dynamic repair process. Wounds can be classified as acute wounds or chronic wounds, effective wound management still major challenge in clinical nursing settings. The microenvironment collectively regulated by internal biomolecules, external drugs, sanitation. Traditional dressings (powders, bandages, sponges, etc.) often have poor therapeutic effects during processes because they cannot respond to the dynamic changes over long-term. Stimulus-responsive biomaterials, which are activated various factors intrinsic influences, hold great promise for precise drug delivery controlled release. Various stimulus-responsive hydrogels been developed recent years, exhibiting range of “smart” properties, such interacting with wound, sensing conditions environmental changes, responding accordingly, thereby effectively promoting healing. This review discusses latest advancements used We introduce design scheme stimulus-response detail based on local biological/biochemical peculiarities (pH, reactive oxygen species glucose, enzymes, physical microenvironments (temperature, light, ultrasound, electric fields, etc.). Furthermore, we explore several promising tissue-engineered constructs (nanofibers, scaffolds, microneedles, microspheres). Finally, summarize basis active research challenges, current progress, development trends field.

Language: Английский

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Engineered hydrogel platform for diabetic wound healing

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160379 - 160379

Published: Feb. 1, 2025

Language: Английский

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3D-exosomes laden multifunctional hydrogel enhances diabetic wound healing via accelerated angiogenesis

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 475, P. 146238 - 146238

Published: Sept. 23, 2023

Language: Английский

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Multifunctional and theranostic hydrogels for wound healing acceleration: An emphasis on diabetic-related chronic wounds

Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 117087 - 117087

Published: Sept. 15, 2023

Language: Английский

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Incorporating copper-based nanosheets into an injectable self-healing hydrogel enables superb repair of infected diabetic wound

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 476, P. 146788 - 146788

Published: Oct. 20, 2023

Language: Английский

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