An S-scheme CeO2/ foveolate g-C3N4 composite with horseradish peroxidase activity for photo-enzyme synergistic catalytic degradation of phenanthrene

Applied Catalysis B Environment and Energy, Journal Year: 2023, Volume and Issue: 337, P. 123005 - 123005

Published: June 16, 2023

Language: Английский

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Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Biosensors, Journal Year: 2023, Volume and Issue: 13(4), P. 461 - 461

Published: April 5, 2023

This review highlights the recent advancements in field of nanozymes and their applications development point-of-care biosensors. The use as enzyme-mimicking components biosensing systems has led to improved performance miniaturization these sensors. unique properties nanozymes, such high stability, robustness, surface tunability, make them an attractive alternative traditional enzymes applications. Researchers have explored a wide range nanomaterials, including metals, metal oxides, metal–organic frameworks, for nanozyme-based Different sensing strategies, colorimetric, fluorescent, electrochemical SERS, been implemented using signal-producing components. Despite numerous advantages, there are also challenges associated with biosensors, stability specificity, which need be addressed wider future biosensors looks promising, potential bring paradigm shift biomolecular sensing. highly specific, multi-enzyme mimicking could lead creation sensitive low-biofouling Integration into diagnostics promises revolutionize healthcare by improving patient outcomes reducing costs while enhancing accuracy sensitivity diagnostic tools.

Language: Английский

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Research progress of nanozymes in colorimetric biosensing: Classification, activity and application

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150612 - 150612

Published: March 21, 2024

Language: Английский

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Cobalt-modulated dual emission carbon dots for ratiometric fluorescent vancomycin detection

RSC Advances, Journal Year: 2024, Volume and Issue: 14(8), P. 5609 - 5616

Published: Jan. 1, 2024

Selective fluorometric protocol for the quantification of vancomycin.

Language: Английский

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Nanozyme as a rising star for metabolic disease management

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 6, 2024

Abstract Nanozyme, characterized by outstanding and inherent enzyme-mimicking properties, have emerged as highly promising alternatives to natural enzymes owning their exceptional attributes such regulation of oxidative stress, convenient storage, adjustable catalytic activities, remarkable stability, effortless scalability for large-scale production. Given the potent regulatory function nanozymes on stress coupled with fact that reactive oxygen species (ROS) play a vital role in occurrence exacerbation metabolic diseases, nanozyme offer unique perspective therapy through multifunctional achieving essential results treatment diseases directly scavenging excess ROS or regulating pathologically related molecules. The rational design strategies, nanozyme-enabled therapeutic mechanisms at cellular level, therapies several typical underlying are discussed, mainly including obesity, diabetes, cardiovascular disease, diabetic wound healing, others. Finally, pharmacokinetics, safety analysis, challenges, outlooks application also presented. This review will provide some instructive perspectives promote development strategies disease therapy. Graphical

Language: Английский

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Single‐Atom Iridium‐doped Carbon Dots Nanozyme with High Peroxidase‐Like Activity as Colorimetric Sensors for Multimodal Detection of Mercury Ions

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Nanozyme-based colorimetric sensors are promising approaches for environmental monitoring, food safety, and medical diagnostics. However, developing novel nanozymes that exhibit high catalytic activity, good dispersion in aqueous solution, sensitivity, selectivity, stability is challenging. In this study, the first time, single-atom iridium-doped carbon dot (SA Ir-CDs) synthesized via a simple situ pyrolysis process. Doping dots with iridium form of single atoms to achieve maximum atomic utilization not only enhances peroxidase (POD)-like activity 178.81 U mg-1 but also improves dispersibility solutions over 30 days. Hence, SA Ir-CD platform developed mercury ions (Hg2+) detection exhibited linear relationship from 0.01 10 µm limit 4.4 nm. Notably, changes color can be observed through naked eye smartphone, enabling convenient field onsite monitoring without need sophisticated analytical equipment. an approach fabricating metal-based POD-like developed, new effective easy-to-use sensor Hg2+ constructed.

Language: Английский

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Multifunctional Carbon Dots for Biomedical Applications: Diagnosis, Therapy, and Theranostic

Small, Journal Year: 2023, Volume and Issue: 20(3)

Published: Sept. 13, 2023

Abstract Designing suitable nanomaterials is an ideal strategy to enable early diagnosis and effective treatment of diseases. Carbon dots (CDs) are luminescent carbonaceous nanoparticles that have attracted considerable attention. Through facile synthesis, they process properties including tunable light emission, low toxicity, energy transformation, leading diverse applications as optically functional materials in biomedical fields. Recently, their potentials been further explored, such enzyme‐like activity ability promote osteogenic differentiation. refined synthesizing strategies carbon dots, a rich treasure trove for new discoveries, stand chance guide significant development applications. In this review, the authors start with brief introduction CDs. By presenting mechanisms examples, focus on how can be used diagnosing treating diseases, bioimaging failure tissues cells, biosensing various pathogenic factors biomarkers, tissue defect repair, anti‐inflammation, antibacterial antiviral, novel oncology treatment. The application integrated follows closely behind. Furthermore, challenges future directions CDs discussed. hope review will provide critical perspectives inspire discoveries prompt advances

Language: Английский

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Signal Amplification Strategy Design in Nanozyme‐Based Biosensors for Highly Sensitive Detection of Trace Biomarkers

Small Methods, Journal Year: 2023, Volume and Issue: 7(11)

Published: Oct. 10, 2023

Abstract Nanozymes show great promise in enhancing disease biomarker sensing by leveraging their physicochemical properties and enzymatic activities. These qualities facilitate signal amplification matrix effects reduction, thus boosting performance. In this review, recent studies from the last five years, concentrating on detection improvement through nanozyme‐based biosensing are examined. This enhancement primarily involves modulations of size, morphology, doping, modification, electromagnetic mechanisms, electron conduction efficiency, surface plasmon resonance nanozymes for increased sensitivity. addition, a comprehensive description synthesis tuning strategies employed has been provided. includes detailed elucidation catalytic mechanisms alignment with fundamental principles enhanced technology, accompanied presentation quantitatively analyzed results. Moreover, diverse applications strip sensing, colorimetric electrochemical surface‐enhanced Raman scattering have outlined. Additionally, limitations, challenges, corresponding recommendations concerning application summarized. Furthermore, insights offered into future development outlook biosensing. review aims to serve not only as reference sensitivity biosensors but also catalyst exploring nanozyme broader

Language: Английский

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Blood-Glucose-Depleting Hydrogel Dressing as an Activatable Photothermal/Chemodynamic Antibacterial Agent for Healing Diabetic Wounds

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(20), P. 24162 - 24174

Published: May 11, 2023

Poorly healing and nonhealing diabetic wounds are challenging to treat as the rapid growth of bacteria due high local glucose content can lead persistent inflammation poor angiogenesis. Herein, a smart hydrogel dressing composed 3,3',5,5'-tetramethylbenzidine/ferrous ion/Pluronic F-127/glucose oxidase (TMB/Fe2+/PF127/GOx) is designed demonstrated consume blood while accelerating wound by generating antibacterial agents in situ. The loaded GOx degrades provide hydrogen peroxide (H2O2) gluconic acid support Fe2+-based Fenton reaction, generated hydroxyl radical (·OH) facilitates oxidation TMB. color change from colorless green caused TMB range between 1 10 mM be monitored visually. Simultaneously, this process induced chemodynamic therapy (CDT) specific generation for killing bacteria. Moreover, oxidized shows strong absorption near infrared (NIR) region so that NIR light converted into heat efficiently photothermal (PTT). As result, nearly 100% Staphylococcus aureus Escherichia coli killed synergistic PTT/CDT, infected skin undergo complete repair along with downregulation interleukin-6 (IL-6) upregulation vascular endothelial factor (VEGF) matrix metallopeptidase-2 (MMP-2). Different traditional dressings give rise secondary injury, excellent thermosensitive properties arising sol/gel phase transition render materials injectable, self-reparable, removable on demand. multifunctional hypoglycemic, chemodynamic, photothermal, antibacterial, on-demand has immense potential treatment wounds.

Language: Английский

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Recent advances in carbon dots-based nanoplatforms: Physicochemical properties and biomedical applications

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 476, P. 146593 - 146593

Published: Oct. 10, 2023

Language: Английский

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