International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 648, P. 123624 - 123624
Published: Nov. 18, 2023
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 201, P. 115055 - 115055
Published: Aug. 17, 2023
The minimally-invasive and painless nature of microneedle (MN) application has enabled the technology to obviate many issues with injectable drug delivery. MNs not only administer therapeutics directly into dermal ocular space, but they can also control release profile active compound over a desired period. To enable prolonged delivery payloads, various MN types have been proposed evaluated, including dissolving MNs, polymeric loaded or coated nanoparticles, fast-separable hollow hydrogel MNs. These intricate yet intelligent platforms provide an attractive approach decrease side effects administration frequency, thus offer potential increase patient compliance. In this review, formulations that are for long-acting address clinical needs myriad diseases discussed. We highlight design aspects, such as polymer selection geometry, in addition computational mathematical modeling necessary help streamline develop high translational value impact. Finally, up-scale manufacturing regulatory hurdles along avenues require further research bring market carefully considered. It is hoped review will insight formulators clinicians judicious materials tandem refined may elegant achieve sustained payloads through simple patch.
Language: Английский
Citations
56
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180
Published: Aug. 23, 2024
Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.
Language: Английский
Citations
20
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 210, P. 115326 - 115326
Published: April 30, 2024
Transdermal administration remains an active research and development area as alternative route for long-acting drug delivery. It avoids major drawbacks of conventional oral (gastrointestinal side effects, low bioavailability, multiple dosing) or parenteral routes (invasiveness, pain, psychological stress bio-hazardous waste generated from needles), thereby increasing patient appeal compliance. This review focuses on the current state transdermal delivery, including adhesive patches, microneedles, molecularly imprinted polymeric systems. Each subsection describes approach key considerations in formulation development, design, process parameters with schematics. An overview commercially available (adhesive) patches delivery (longer than 24 h), well advanced formulations such core-shell, nanoformulations-incorporated stimuli-responsive 3D-printed polymers is also provided. Finally, we elaborated translational aspects, challenges patch future directions clinical advancement new products
Language: Английский
Citations
18
Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)
Published: Feb. 6, 2025
Abstract The use of microneedles (MNs) has been established as an effective transdermal drug delivery strategy that extensively deployed for treating various diseases, including skin diseases. MNs can surpass the constraints conventional methods by their superior safety and efficacy through precise targeting, while simultaneously enabling painless delivery. Currently, are increasingly used carriers delivery, with loading insoluble drugs to improve treatment efficiency or combining bioactive substances construction efficient system maximize effects substances. preparation diverse, them meet requirements most applications. emergence addressed shortcomings associated drugs, expanded applications substances, improved in clinical practice. This review summarizes current information on application a variety such psoriasis, vitiligo, alopecia, hypertrophic scarring, atopic dermatitis, melanoma, acne, infections. future opportunities diseases also discussed. Despite substantial progress vectors, issues low poor mechanical strength during remain main challenges. Therefore, implementation MNs-based therapies remains limited, highlighting key research.
Language: Английский
Citations
3
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(13), P. 15701 - 15717
Published: March 20, 2024
Although topical application of minoxidil is a widely used, FDA-approved therapy for androgenetic alopecia (AGA) treatment, it suffers from low bioavailability, the requirement frequent long-term use, and side effects. With similar structure as minoxidil, kopexil kopyrrol are less toxic have been commercialized, but show an inferior hair regeneration effect compared to minoxidil. Herein, we developed hyaluronic acid (HA)-based dissolvable microneedles (MNs) delivery platform integrated with coencapsulated nanoliposomes (KK-NLPs) effectively safely treat AGA. Facilitated by MNs, encapsulated KK-NLPs performed efficient skin penetration enhanced cellular internalization into human dermal papilla cells. Furthermore, within target cells, codelivered synergistic effects orchestrating upregulation in expression Ki67, β-catenin, vascular endothelial growth factor (VEGF), CD31. These molecular responses collectively foster cell proliferation, migration, antioxidative effects, thereby facilitating expedited progression follicles (HFs) anagen phase promoting peripheral angiogenesis. Notably, KK-NLPs-integrated MNs treatment group exhibits noteworthy vivo, identical or superior therapeutic at much lower dosage than that results suggest great potential this codelivery nanoliposomes-integrated AGA safe way.
Language: Английский
Citations
13
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114571 - 114571
Published: Feb. 1, 2025
Language: Английский
Citations
1
Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(2)
Published: Feb. 26, 2025
Language: Английский
Citations
1
Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 233, P. 113636 - 113636
Published: Nov. 11, 2023
Language: Английский
Citations
20
Journal of Pharmacy & Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 27
Published: March 20, 2024
Microneedle (MN)-assisted drug delivery technology has gained increasing attention over the past two decades. Its advantages of self-management and being minimally invasive could allow this to be an alternative hypodermic needles. MNs can penetrate stratum corneum deliver active ingredients body through dermal tissue in a controlled sustained release. Long-acting polymeric reduce administration frequency improve patient compliance therapeutic outcomes, especially management chronic diseases. In addition, long-acting avoid gastrointestinal reactions side effects, which potential value for clinical application. paper, advances design strategies applications are reviewed. We also discuss challenges scale manufacture regulations MN systems. These aspects will accelerate effective translation products.
Language: Английский
Citations
8
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 663, P. 124547 - 124547
Published: Aug. 2, 2024
Language: Английский
Citations
7