Surgical Navigation for Malignancies Guided by Near‐Infrared‐II Fluorescence Imaging

Small Methods, Journal Year: 2021, Volume and Issue: 5(3)

Published: Jan. 18, 2021

Near-infrared (NIR) fluorescence imaging is an emerging noninvasive modality, with unique advantages in guiding tumor resection surgery, thanks to its high sensitivity and instantaneity. In the past decade, studies on conventional NIR window (NIR-I, 750-900 nm) have gradually focused second (NIR-II, 1000-1700 nm). With reduced light scattering, photon absorption, auto-fluorescence qualities, NIR-II significantly improves penetration depths signal-to-noise ratios bio-imaging. Recently, several applied navigating cancer including localizing cancers, assessing surgical margins, tracing lymph nodes, mapping important anatomical structures. These exemplified significant prospects of this new approach. review, agents some complex applications for surgeries are summarized. Future challenges clinical translation also discussed.

Language: Английский

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Construction of a 980 nm laser-activated Pt(II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization

Science China Chemistry, Journal Year: 2022, Volume and Issue: 66(1), P. 155 - 163

Published: Dec. 8, 2022

Language: Английский

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Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

Chemical Reviews, Journal Year: 2023, Volume and Issue: 124(2), P. 554 - 628

Published: Nov. 22, 2023

In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.

Language: Английский

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Tracking tumor heterogeneity and progression with near‐infrared II fluorophores

Exploration, Journal Year: 2023, Volume and Issue: 3(2)

Published: March 16, 2023

Abstract Heterogeneous cells are the main feature of tumors with unique genetic and phenotypic characteristics, which can stimulate differentially progression, metastasis, drug resistance. Importantly, heterogeneity is pervasive in human malignant tumors, identification degree tumor individual progression a critical task for treatment. However, current medical tests cannot meet these needs; particular, need noninvasive visualization single‐cell heterogeneity. Near‐infrared II (NIR‐II, 1000–1700 nm) imaging exhibits an exciting prospect non‐invasive monitoring due to high temporal‐spatial resolution. More importantly, NIR‐II displays more extended tissue penetration depths reduced backgrounds because significantly lower photon scattering autofluorescence than traditional near‐infrared I (NIR‐I) imaging. In this review, we summarize systematically advances made imaging, especially detection as well As visual inspection modality, shows promising prospects understanding differences envisioned have potential be used clinically.

Language: Английский

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Leveraging Semiconducting Polymer Nanoparticles for Combination Cancer Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(1)

Published: Oct. 21, 2023

Abstract Cancer immunotherapy has become a promising method for cancer treatment, bringing hope to advanced patients. However, immune‐related adverse events caused by also bring heavy burden Semiconducting polymer nanoparticles (SPNs) as an emerging nanomaterial with high biocompatibility, can eliminate tumors and induce tumor immunogenic cell death through different therapeutic modalities, including photothermal therapy, photodynamic sonodynamic therapy. In addition, SPNs work functional nanocarrier synergize variety of immunomodulators amplify anti‐tumor immune responses. this review, SPNs‐based combination is comprehensively summarized according the SPNs’ modalities type loaded immunomodulators. The in‐depth understanding existing will hopefully inspire design more novel nanomaterials potent effects, ultimately promote their clinical translation.

Language: Английский

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Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics

ACS Nano, Journal Year: 2024, Volume and Issue: 18(6), P. 4683 - 4703

Published: Jan. 31, 2024

Organic fluorescent molecules with emission in the second near-infrared (NIR-II) biological window have aroused increasing investigation cancer phototheranostics. Among these studies, Benzobisthiadiazole (BBT), high electron affinity, is widely utilized as acceptor constructing donor–acceptor–donor (D-A-D) structured fluorophores intensive (NIR) absorption and NIR-II fluorescence. Until now, numerous BBT-based dyes been employed tumor phototheranostics due to their exceptional structure tunability, biocompatibility, photophysical properties. This review systematically overviews research progress of small molecular focuses on molecule design bioapplications. First, engineering strategies fine-tune properties high-performance are discussed detail. Then, applications optical imaging phototherapy highlighted. Finally, current challenges future prospects also summarized. believed significantly promote further BBT-derived for

Language: Английский

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Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

Advanced Science, Journal Year: 2024, Volume and Issue: 11(20)

Published: March 19, 2024

Abstract Layered double hydroxides (LDHs) have been widely studied for biomedical applications due to their excellent properties, such as good biocompatibility, degradability, interlayer ion exchangeability, high loading capacity, pH‐responsive release, and large specific surface area. Furthermore, the flexibility in structural composition ease of modification LDHs makes it possible develop specifically functionalized meet needs different applications. In this review, recent advances applications, which include LDH‐based drug delivery systems, cancer diagnosis therapy, tissue engineering, coatings, functional membranes, biosensors, are comprehensively discussed. From these various research fields, can be seen that there is great potential possibility use However, at same time, must recognized actual clinical translation still very limited. Therefore, current limitations related on discussed by combining limited examples with requirements biomaterials. Finally, an outlook future provided.

Language: Английский

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Reactive Oxygen Species Amplifier for Apoptosis-Ferroptosis Mediated High-Efficiency Radiosensitization of Tumors

ACS Nano, Journal Year: 2024, Volume and Issue: 18(14), P. 10288 - 10301

Published: April 1, 2024

Insufficient reactive oxygen species (ROS) production and radioresistance have consistently contributed to the failure of radiotherapy (RT). The development a biomaterial capable activating ROS-induced apoptosis ferroptosis is potential strategy enhance RT sensitivity. To achieve precision high-efficiency RT, theranostic nanoplatform Au/Cu nanodots (Au/CuNDs) were designed for dual-mode imaging, amplifying ROS generation, inducing apoptosis-ferroptosis sensitize RT. A large amount derived from three aspects: (1) When exposed ionizing radiation, Au/CuNDs effectively absorb photons emit various electrons, which can interact with water produce ROS. (2) act as catalase-like abundant through Fenton reaction hydrogen peroxide overexpressed tumor cells. (3) deplete glutathione, causes accumulation Large amounts radiation further lead by increasing DNA damage, enhancing lipid peroxidation, significantly improving therapeutic efficiency Furthermore, serve an excellent nanoprobe high-resolution near-infrared fluorescence imaging computed tomography tumors. promising performance shows their application in clinical cancer detection imaging-guided minimizing damage adjacent normal tissues during In summary, our developed integrates sensitizes via ROS-activated apoptosis-ferroptosis, offering prospect diagnosis treatment.

Language: Английский

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Combination of Efficient Red Fluorescence and High Photothermal Conversion in the Second Near‐Infrared Window from Carbon Dots through Photoinduced Sodium‐Doping Approach

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 12, 2024

Abstract Carbon dots (CDs) are highly desired in biological applications. However, achieving a balance between photoluminescence (PL) efficiency and photothermal conversion (PTCE) is challenging. In this study, an unprecedent combination of efficient red fluorescence high PTCE the second near‐infrared (NIR‐II) window sodium‐doped CDs system reported. Upon 808 nm laser irradiation, photo‐induced oxidation–reduction reactions happened on surface sodium cation‐functionalized (Na‐CDs), leading to partial reduction surface‐functionalized (Na) ions. The photo‐reduced Na atoms coordinated with sp 2 C domains core, resulting Na‐doped (ir‐Na‐CDs) enhanced absorption band NIR‐II 43% under 1064 irradiation (1 W cm −2 ). Composing ir‐Na‐CDs bovine serum albumin (BSA) PLQY emission 31% water without diminishing region. Transient spectra revealed that no energy transfer occurred center band, revealing novel independent Janus photophysical processes. Moreover, ir‐Na‐CDs@BSA exhibited negligible low cytotoxicity demonstrated tumor accumulation capacity after intravenous injection, enabling effective therapy

Language: Английский

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Versatile Biomass‐Based Injectable Photothermal Hydrogel for Integrated Regenerative Wound Healing and Skin Bioelectronics

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 11, 2024

Abstract The continuously growing utilization of wound healing materials and skin bioelectronics urges the development flexible hydrogels for personal therapy health management. Versatile conductive prepared from natural biomass are ideal candidates as one promising solutions chronic Here, study proposes a kind robust (strain: 1560.8%), adhesive, self‐healing, injectable, antibacterial (sterilization rate: 99%), near‐infrared (NIR) photothermal responsive, biocompatible, hydrogel (CPPFe@TA) composed carboxymethyl cellulose tannic acid/iron ion complex (TA@Fe 3+ ), featuring rapid self‐assembly tunable crosslinking time. TA@Fe facilitated self‐catalysis polymerization reaction, time could be controlled by adjusting Fe concentration. Under NIR irradiation, exhibited remarkable performance. In full‐thickness defect repair experiment on mice, dressing significantly enhanced healing. After 14 days, rate (95.49%) CPPFe@TA3 + treatment greatly exceeded that commercial dressings. Meanwhile, has good electrical conductivity thermo‐responsiveness, making them in physiological signal monitoring rehabilitation exercise This work therefore offers strategy developing versatile biomass‐based hydrogels, which is expected to applicable integrated regenerative bioelectronics.

Language: Английский

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