Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy DOI
Ke Ma,

Kezheng Chen,

Sheng‐Lin Qiao

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: 24(4)

Published: March 19, 2024

Abstract Layered double hydroxides (LDH) are a class of functional anionic clays that typically consist orthorhombic arrays metal with anions sandwiched between the layers. Due to their unique properties, including high chemical stability, good biocompatibility, controlled drug loading, and enhanced bioavailability, LDHs have many potential applications in medical field. Especially fields bioimaging tumor therapy. This paper reviews research progress nanocomposites field imaging First, structure advantages LDH discussed. Then, several commonly used methods for preparation presented, co‐precipitation, hydrothermal ion exchange methods. Subsequently, recent advances layered cancer therapy highlighted. Finally, based on current research, we summaries prospects challenges diagnosis

Language: Английский

Activatable molecular probes for fluorescence-guided surgery, endoscopy and tissue biopsy DOI
Yan Zhang, Guopeng Zhang,

Ziling Zeng

et al.

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 51(2), P. 566 - 593

Published: Dec. 20, 2021

The real-time, dynamic optical visualization of lesions and margins ensures not only complete resection the malignant tissues but also better preservation vital organs/tissues during surgical procedures. Most imaging probes with an "always-on" signal encounter high background noise due to their non-specific accumulation in normal tissues. By contrast, activatable molecular "turn on" signals upon reaction targeted biomolecules that are overexpressed cells, offering target-to-background ratios specificity sensitivity. This review summarizes recent progress diagnosis. design principle mechanism discussed, followed by specific emphasis on applications ranging from fluorescence-guided surgery endoscopy tissue biopsy. Finally, potential challenges perspectives field probe-enabled discussed.

Language: Английский

Citations

175
Fluorescence image-guided tumour surgery DOI Open Access
Kun Wang, Yang Du, Zeyu Zhang

et al.

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(3), P. 161 - 179

Published: Feb. 3, 2023

Language: Английский

Citations

118
Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics DOI
Shubham Roy,

Neelanjana Bag,

Souravi Bardhan

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114821 - 114821

Published: April 9, 2023

Language: Английский

Citations

97
Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment DOI

Yao Xiong,

Yan Rao,

Jiawei Hu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 10, 2023

Rapid advancements in materials science and nanotechnology, intertwined with oncology, have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy for cancer. The breast's superficial anatomical location aesthetic significance render breast cancer particularly pertinent candidate the clinical application of PTT following melanoma. This review comprehensively explores research conducted on various types nanoparticles employed elaborates their specific roles mechanisms action. integration existing therapies is scrutinized, underscoring its potential synergistic outcomes. Additionally, underlying consequential modifications to tumor microenvironment after are elaborated from medical perspective. Future directions suggested, an emphasis development integrative platforms that combine multiple therapeutic approaches optimization nanoparticle synthesis enhanced efficacy. goal push boundaries toward comprehensive, clinically applicable

Language: Английский

Citations

90
Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region DOI
Yang Yang,

Qunying Jiang,

Fan Zhang

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 124(2), P. 554 - 628

Published: Nov. 22, 2023

In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.

Language: Английский

Citations

74
Semiconducting Polymer Nanoparticles with Intramolecular Motion‐Induced Photothermy for Tumor Phototheranostics and Tooth Root Canal Therapy DOI

Xingchen Duan,

Qianyu Zhang,

Yu Jiang

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(17)

Published: March 3, 2022

Much effort is devoted to develop agents with superior photoacoustic/photothermal properties for improved disease diagnosis and treatment. Herein, a new fused two isoindigo (DIID)-based semiconducting conjugated polymer (named PBDT-DIID) rationally designed synthesized strong near-infrared absorption band ranging from 700 1000 nm. Water-dispersing nanoparticles (NPs) of PBDT-DIID are prepared good biocompatibility rather high photothermal conversion efficiency (70.6%), as the active excited-state intramolecular twist around central double bonds in DIID permits most absorbed excitation energy flow heat deactivation pathway through internal conversion. The photoacoustic signal can be further magnified by incorporation polylactide (PLA) NP core confine generated within NPs. resultant doped NPs show excellent performance imaging-guided therapy an orthotopic 4T1 breast tumor-bearing mouse model. It also found that effect safe quite efficacious highly improve root canal treatment outcome heating 1% NaClO solution inside upon 808 nm laser irradiation human extracted tooth infection

Language: Английский

Citations

73
Molecular Programming of NIR‐IIb‐Emissive Semiconducting Small Molecules for In Vivo High‐Contrast Bioimaging Beyond 1500 nm DOI
Yi Yuan, Zhe Feng, Shengliang Li

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(19)

Published: March 21, 2022

Materials with long-wavelength second near-infrared (NIR-II) emission are highly desired for in vivo dynamic visualizating of microstructures deep tissues. Herein, by employing an atom-programming strategy, a series fluorescent semiconducting oligomers (SOMs) tunable NIR-IIb emissions developed bioimaging applications. After self-assembly into nanoparticles (NPs), they show good brightness, high photostability, and satisfactory biocompatibility. The SOM NPs applied as probes high-resolution imaging whole-body hind-limb blood vessels, biliary tract, bladder their over 1500 nm. This work demonstrates strategy constructing small molecules enhanced NIR-II fluorescence deep-tissue imaging, affording new insight advancing molecular design fluorophores.

Language: Английский

Citations

73
A Gas/phototheranostic Nanocomposite Integrates NIR‐II‐Peak Absorbing Aza‐BODIPY with Thermal‐Sensitive Nitric Oxide Donor for Atraumatic Osteosarcoma Therapy DOI

Zhijie Fang,

Jiaxin Zhang,

Zhenxiong Shi

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(35)

Published: April 20, 2023

Photothermal therapy (PTT) has received increasing interest in cancer therapeutics owing to its excellent efficacy and controllability. However, there are two major limitations PTT applications, which the tissue penetration depth of lasers within absorption range photothermal agents unavoidable empyrosis induced by high-energy lasers. Herein, a gas/phototheranostic nanocomposite (NA1020-NO@PLX) is engineered that integrates second near-infrared-peak (NIR-II-peak) absorbing aza-boron-dipyrromethenes (aza-BODIPY,NA1020) with thermal-sensitive nitric oxide (NO) donor (S-nitroso-N-acetylpenicillamine, SNAP). An enhanced intramolecular charge transfer mechanism proposed achieve NIR-II-peak absorbance (λmax = 1020 nm) on NA1020, thereby obtaining deep depth. The NA1020 exhibits remarkable conversion, making it feasible for deep-tissue orthotopic osteosarcoma providing favorable NIR-II emission precisely pinpoint tumor visible process. simultaneously investigated atraumatic therapeutic process an cell apoptosis indicates feasibility synergistic NO/low-temperature osteosarcoma. this strategy optimizes existing present repeatable tumors, validating potential clinical applications.

Language: Английский

Citations

53
Delivering metal ions by nanomaterials: Turning metal ions into drug-like cancer theranostic agents DOI

Chenguang Liu,

Lingxiao Guo,

Yong Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 494, P. 215332 - 215332

Published: July 17, 2023

Language: Английский

Citations

49
Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo DOI
Qinrui Fu, Xiao Yang, Mengzhen Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3916 - 3968

Published: Jan. 23, 2024

Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological pathological states. Therefore, it is crucial to design imaging systems capable real-time detection dynamic changes for accurate diagnosis effective treatment diseases. Recently, ratiometric has emerged as a widely used technique sensing due its advantage circumventing limitations inherent conventional intensity-dependent signal readout methods while also providing built-in self-calibration correction. Here, recent progress probes their applications outlined. Ratiometric classified according mechanisms, photoacoustic imaging, optical including photoluminescence self-luminescence magnetic resonance dual-modal discussed. The such pH, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, hypoxia discussed detail. Additionally, this Review presents an overview challenges faced field along future research directions.

Language: Английский

Citations

34