Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Oct. 20, 2022
Abstract
5-Aminolevulinic
acid-based
photodynamic
therapy
heavily
depends
on
the
biological
transformation
efficiency
of
5-aminolevulinic
acid
to
protoporphyrin
IX,
while
lack
an
effective
delivery
system
and
imaging
navigation
are
major
hurdles
in
improving
accumulation
IX
optimizing
therapeutic
parameters.
Herein,
we
leverage
a
synthetic
biology
approach
construct
transdermal
theranostic
microneedle
patch
integrated
with
catalase
co-loaded
tumor
acidity-responsive
copper-doped
calcium
phosphate
nanoparticles
for
efficient
by
maximizing
enrichment
intratumoral
IX.
We
show
that
continuous
oxygen
generation
vivo
reverses
hypoxia,
enhances
blocking
efflux
(downregulating
hypoxia-inducible
factor-1α
ferrochelatase)
upregulates
biosynthesis
(providing
exogenous
upregulating
ALA-synthetase).
In
fluorescence/photoacoustic
duplex
can
monitor
saturation
metabolic
kinetics
simultaneously.
This
thus
facilitates
optimization
parameters
different
cancers
realize
Ca
2+
/Cu
-interferences-enhanced
repeatable
therapy,
making
this
promising
clinical
practice.
Small,
Journal Year:
2021,
Volume and Issue:
18(6)
Published: Nov. 2, 2021
Abstract
Chemodynamic
therapy
(CDT),
a
novel
cancer
therapeutic
strategy
defined
as
the
treatment
using
Fenton
or
Fenton‐like
reaction
to
produce
•OH
in
tumor
region,
was
first
proposed
by
Bu,
Shi,
and
co‐workers
2016.
Recently,
with
rapid
development
of
nanomaterials,
CDT
has
attracted
tremendous
attention
because
its
unique
advantages:
1)
It
is
tumor‐selective
low
side
effects;
2)
process
does
not
depend
on
external
field
stimulation;
3)
it
can
modulate
hypoxic
immunosuppressive
microenvironment;
4)
cost
low.
In
addition
Fe‐involved
strategies,
reaction‐mediated
strategies
have
also
been
proposed,
which
are
based
many
other
metal
elements
including
copper,
manganese,
cobalt,
titanium,
vanadium,
palladium,
silver,
molybdenum,
ruthenium,
tungsten,
cerium,
zinc.
Moreover,
combined
therapies
like
chemotherapy,
radiotherapy,
phototherapy,
sonodynamic
therapy,
immunotherapy
for
achieving
enhanced
anticancer
effects.
Besides,
there
studies
that
extend
application
antibacterial
field.
This
review
introduces
latest
advancements
nanomaterials‐involved
from
2018
present
proposes
current
limitations
well
future
research
directions
related
Exploration,
Journal Year:
2022,
Volume and Issue:
2(2)
Published: March 7, 2022
Chemodynamic
therapy
(CDT)
has
emerged
to
be
a
frontrunner
amongst
reactive
oxygen
species-based
cancer
treatment
modalities.
CDT
utilizes
endogenous
H
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(40)
Published: July 30, 2022
Abstract
Cuproptosis
is
a
very
newly
recognized
regulated
cell
death
modality
that
distinct
from
known
mechanisms
and
shows
enormous
prospect
in
cancer
treatment.
However,
its
efficacy
copper‐dependent
restricted
by
strictly
copper
metabolism.
Herein,
novel
copper/iron
hybrid
hollow
amorphous
metal
organic
framework
(HaMOF)
developed
as
an
oxidative
stress
amplifier
metabolic
disrupter
for
synergistic
cuproptosis/ferroptosis/apoptosis
anticancer
therapy.
The
HaMOF
fabricated
Cu
2+
,
3,3′‐dithiobis(propionohydrazide)
Fe
3+
via
unsaturated
coordination‐etching
integration
strategy,
then
doxorubicin
loaded
followed
surface
decoration
with
hyaluronan.
obtained
DOX@Fe/CuTH
exhibits
tumor
microenvironment‐triggered
catalytic
therapeutic
property,
wherein
it
can
amplify
cellular
simultaneously
boosting
H
2
O
production
depleting
glutathione.
Moreover,
cause
mitochondrial
dysfunction
downregulate
the
expressions
of
transporter
ATP7A
iron
FPN
1,
thereby
leading
to
disorders
high
retentions
cytoplasm
•OH
generation.
overloaded
lipoylated
protein
dihydrolipoamide
S‐acetyltransferase
aggregation
lead
cuproptosis.
Collectively,
both
augmented
induce
potent
ferroptosis,
which
synergizes
cuproptosis
DOX‐mediated
apoptosis
efficiently
suppress
growth.
This
bimetallic
nanoplatform
provides
new
paradigm
boost
cuproptosis‐related
therapies.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(3), P. 4228 - 4238
Published: Feb. 25, 2022
The
high
glutathione
(GSH)
content
in
tumor
cells
strongly
affects
the
efficiency
of
chemodynamic
therapy
(CDT).
Despite
devoted
efforts,
it
still
remains
a
formidable
challenge
for
manufacturing
tumor-specific
CDT
with
rapid
and
thorough
depletion
GSH.
Herein,
multistage
GSH-consuming
is
presented.
By
consuming
reserved
GSH
inhibiting
both
raw
materials
energy
supply
synthesis
cancer
cells,
achieves
highly
potent
exhaustion.
Our
used
glycolysis
inhibitor
cuts
off
specific
to
increase
sensitivity
CDT.
Furthermore,
starvation
effect
can
stimulate
protective
mode
normal
cells.
Since
nanocarrier
are
responsive
microenvironment,
this
makes
more
selective
work
not
only
fabricates
nanomedicine
exhausted
function
but
also
uses
metabolic
differences
achieve
therapy.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: May 23, 2023
The
immunologically
"cold"
microenvironment
of
triple
negative
breast
cancer
results
in
resistance
to
current
immunotherapy.
Here,
we
reveal
the
immunoadjuvant
property
gas
therapy
with
cyclic
GMP-AMP
synthase-stimulator
interferon
genes
(cGAS-STING)
pathway
activation
augment
aggregation-induced
emission
(AIE)-active
luminogen
(AIEgen)-based
photoimmunotherapy.
A
virus-mimicking
hollow
mesoporous
tetrasulfide-doped
organosilica
is
developed
for
co-encapsulation
AIEgen
and
manganese
carbonyl
fabricate
nanoadjuvant.
As
tetra-sulfide
bonds
are
responsive
intratumoral
glutathione,
nanoadjuvant
achieves
tumor-specific
drug
release,
promotes
photodynamic
therapy,
produces
hydrogen
sulfide
(H2S).
Upon
near-infrared
laser
irradiation,
AIEgen-mediated
phototherapy
triggers
burst
carbon
monoxide
(CO)/Mn2+.
Both
H2S
CO
can
destroy
mitochondrial
integrity
induce
leakage
DNA
into
cytoplasm,
serving
as
immunoadjuvants
activate
cGAS-STING
pathway.
Meanwhile,
Mn2+
sensitize
cGAS
STING-mediated
type
I
production.
Consequently,
potentiates
photoimmunotherapy
poorly
immunogenic
tumors
female
mice.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(11), P. 4799 - 4809
Published: Feb. 22, 2022
Chemodrug
resistance
is
a
major
reason
accounting
for
tumor
recurrence.
Given
the
mechanistic
complexity
of
chemodrug
resistance,
molecular
inhibitors
and
targeting
drugs
often
fail
to
eliminate
drug-resistant
cancer
cells,
sometimes
even
promote
chemoresistance
by
activating
alternative
pathways.
Here,
exploiting
biochemical
fragility
high-level
but
dynamically
balanced
cellular
redox
homeostasis
in
we
design
nanosized
copper/catechol-based
metal-organic
framework
(CuHPT)
that
effectively
disturbs
this
tilting
balance
toward
oxidative
stress.
Within
CuHPT
starts
disassembly
triggered
persistent
consumption
glutathione
(GSH).
simultaneously
releases
two
structural
elements:
catechol
ligands
reductive
copper
ions
(Cu+).
Both
them
cooperatively
function
amplify
production
intracellular
radical
species
(ROS)
via
auto-oxidation
Fenton-like
reactions
through
exhausting
GSH.
By
drastically
heightening
stress,
exhibits
selective
potent
cytotoxicity
multiple
cells.
Importantly,
inhibits
vivo
growth
doubles
survival
time
tumor-bearing
mice.
Thus,
along
with
CuHPT's
good
biocompatibility,
our
biochemical,
cell
biological,
preclinical
animal
model
data
provide
compelling
evidence
supporting
notion
copper-based
MOF
predesigned
smart
therapeutic
against
cancers
precisely
deconstructing
their
homeostasis.
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
61(13)
Published: Dec. 21, 2021
Combination
therapy
based
on
different
mechanisms
of
cell
death
has
shown
promise
in
tumor
therapy.
However,
when
modalities
are
integrated,
the
maximum
synergy
therapeutic
effects
is
often
lacking
design.
Herein,
we
report
a
cancer
theranostic
nanomedicine
formula
developed
by
considering
action
ferroptosis
and
photothermal
effect
combination
The
croconaine
molecule
was
encapsulated
as
both
converter
an
iron-chelating
agent
with
BSA,
thus
leading
to
biocompatible
stable
Cro-Fe@BSA
nanoparticles
(NPs).
NPs
milieu
showed
activated
enhanced
radical
formation
owing
temperature-dependent
Fenton
reaction
kinetics,
while
during
turn
prevented
heat-induced
heat
shock
proteins
self-protection
mechanism
cells
response
heat.
activatable
photoacoustic
magnetic
resonance
imaging
performance
also
enabled
safe
reliable
theranostics.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(9), P. 13513 - 13553
Published: Sept. 1, 2022
Prodrugs
are
chemically
modified
drug
molecules
that
inactive
before
administration.
After
administration,
they
converted
in
situ
to
parent
drugs
and
induce
the
mechanism
of
action.
The
development
prodrugs
has
upgraded
conventional
treatments
terms
bioavailability,
targeting,
reduced
side
effects.
Especially
cancer
therapy,
application
achieved
substantial
therapeutic
From
serendipitous
discovery
early
stage
functional
design
with
pertinence
nowadays,
importance
is
self-evident.
At
present,
studying
stimuli-responsive
activation
mechanisms,
regulating
stimuli
intensity
vivo,
designing
nanoscale
prodrug
formulations
major
strategies
promote
prodrugs.
In
this
review,
we
provide
an
outlook
recent
cutting-edge
studies
on
nanosystems
from
these
three
aspects.
We
also
discuss
prospects
challenges
future
such