Photo-Enhanced Chemotherapy Performance in Bladder Cancer Treatment via Albumin Coated AIE Aggregates DOI
Keke Ding, Lirong Wang,

Jiamiao Zhu

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 7535 - 7546

Published: April 12, 2022

The implementation of cisplatin-based neoadjuvant chemotherapy (NAC) plays a key role in conjunction with surgical resection preventing bladder cancer progression and recurrence. However, the significant dose-dependent toxic side effects NAC are still major challenge. To solve this problem, we developed photoenhanced (PECC) strategy based on AIEgen ((E)-3-(2-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1,1-dimethyl-1H-3λ4-benzo[e]indol-3-yl)propane-1-sulfonate), which is abbreviated as BITT. Multifunctional BITT@BSA–DSP nanoparticles (NPs) were employed an albumin-based nanocarrier decorated cisplatin(IV) prodrug loaded to produce strong near-infrared fluorescence imaging (NIR FLI), they exhibited good photoenhancement performance via photodynamic therapy (PDT) photothermal (PTT). In vitro results demonstrated that NPs could be efficiently taken up by cells reduced release Pt (II) under reductase, ensuring effect. Furthermore, both vivo evaluation verified integration NIR FL imaging-guided PECC promoted sensitivity cisplatin negligible effects. This work provides promising enhance multiple cancers drugs even achieve effective treatments for drug-resistant cancers.

Language: Английский

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances DOI

Chenyang Jia,

Yuxin Guo, Fu‐Gen Wu

et al.

Small, Journal Year: 2021, Volume and Issue: 18(6)

Published: Nov. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Language: Английский

Citations

455

Strategies for enhancing cancer chemodynamic therapy performance DOI
Deblin Jana,

Yanli Zhao

Exploration, Journal Year: 2022, Volume and Issue: 2(2)

Published: March 7, 2022

Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species-based cancer treatment modalities. CDT utilizes endogenous H

Language: Английский

Citations

199

A Hollow Amorphous Bimetal Organic Framework for Synergistic Cuproptosis/Ferroptosis/Apoptosis Anticancer Therapy via Disrupting Intracellular Redox Homeostasis and Copper/Iron Metabolisms DOI
Weijun Xu, Junmin Qian,

Guanghui Hou

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(40)

Published: July 30, 2022

Abstract Cuproptosis is a very newly recognized regulated cell death modality that distinct from known mechanisms and shows enormous prospect in cancer treatment. However, its efficacy copper‐dependent restricted by strictly copper metabolism. Herein, novel copper/iron hybrid hollow amorphous metal organic framework (HaMOF) developed as an oxidative stress amplifier metabolic disrupter for synergistic cuproptosis/ferroptosis/apoptosis anticancer therapy. The HaMOF fabricated Cu 2+ , 3,3′‐dithiobis(propionohydrazide) Fe 3+ via unsaturated coordination‐etching integration strategy, then doxorubicin loaded followed surface decoration with hyaluronan. obtained DOX@Fe/CuTH exhibits tumor microenvironment‐triggered catalytic therapeutic property, wherein it can amplify cellular simultaneously boosting H 2 O production depleting glutathione. Moreover, cause mitochondrial dysfunction downregulate the expressions of transporter ATP7A iron FPN 1, thereby leading to disorders high retentions cytoplasm •OH generation. overloaded lipoylated protein dihydrolipoamide S‐acetyltransferase aggregation lead cuproptosis. Collectively, both augmented induce potent ferroptosis, which synergizes cuproptosis DOX‐mediated apoptosis efficiently suppress growth. This bimetallic nanoplatform provides new paradigm boost cuproptosis‐related therapies.

Language: Английский

Citations

162

A Metabolic Multistage Glutathione Depletion Used for Tumor-Specific Chemodynamic Therapy DOI
Ying Huang, Si Wu, Lu Zhang

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 4228 - 4238

Published: Feb. 25, 2022

The high glutathione (GSH) content in tumor cells strongly affects the efficiency of chemodynamic therapy (CDT). Despite devoted efforts, it still remains a formidable challenge for manufacturing tumor-specific CDT with rapid and thorough depletion GSH. Herein, multistage GSH-consuming is presented. By consuming reserved GSH inhibiting both raw materials energy supply synthesis cancer cells, achieves highly potent exhaustion. Our used glycolysis inhibitor cuts off specific to increase sensitivity CDT. Furthermore, starvation effect can stimulate protective mode normal cells. Since nanocarrier are responsive microenvironment, this makes more selective work not only fabricates nanomedicine exhausted function but also uses metabolic differences achieve therapy.

Language: Английский

Citations

143

Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation DOI Creative Commons
Kaiyuan Wang, Yang Li, Xia Wang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 23, 2023

The immunologically "cold" microenvironment of triple negative breast cancer results in resistance to current immunotherapy. Here, we reveal the immunoadjuvant property gas therapy with cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway activation augment aggregation-induced emission (AIE)-active luminogen (AIEgen)-based photoimmunotherapy. A virus-mimicking hollow mesoporous tetrasulfide-doped organosilica is developed for co-encapsulation AIEgen and manganese carbonyl fabricate nanoadjuvant. As tetra-sulfide bonds are responsive intratumoral glutathione, nanoadjuvant achieves tumor-specific drug release, promotes photodynamic therapy, produces hydrogen sulfide (H2S). Upon near-infrared laser irradiation, AIEgen-mediated phototherapy triggers burst carbon monoxide (CO)/Mn2+. Both H2S CO can destroy mitochondrial integrity induce leakage DNA into cytoplasm, serving as immunoadjuvants activate cGAS-STING pathway. Meanwhile, Mn2+ sensitize cGAS STING-mediated type I production. Consequently, potentiates photoimmunotherapy poorly immunogenic tumors female mice.

Language: Английский

Citations

141

Copper-Based Metal–Organic Framework Overcomes Cancer Chemoresistance through Systemically Disrupting Dynamically Balanced Cellular Redox Homeostasis DOI
Jia Liu, Ye Yuan,

Yanni Cheng

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(11), P. 4799 - 4809

Published: Feb. 22, 2022

Chemodrug resistance is a major reason accounting for tumor recurrence. Given the mechanistic complexity of chemodrug resistance, molecular inhibitors and targeting drugs often fail to eliminate drug-resistant cancer cells, sometimes even promote chemoresistance by activating alternative pathways. Here, exploiting biochemical fragility high-level but dynamically balanced cellular redox homeostasis in we design nanosized copper/catechol-based metal-organic framework (CuHPT) that effectively disturbs this tilting balance toward oxidative stress. Within CuHPT starts disassembly triggered persistent consumption glutathione (GSH). simultaneously releases two structural elements: catechol ligands reductive copper ions (Cu+). Both them cooperatively function amplify production intracellular radical species (ROS) via auto-oxidation Fenton-like reactions through exhausting GSH. By drastically heightening stress, exhibits selective potent cytotoxicity multiple cells. Importantly, inhibits vivo growth doubles survival time tumor-bearing mice. Thus, along with CuHPT's good biocompatibility, our biochemical, cell biological, preclinical animal model data provide compelling evidence supporting notion copper-based MOF predesigned smart therapeutic against cancers precisely deconstructing their homeostasis.

Language: Английский

Citations

137

Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy DOI

Zhaoyou Chu,

Juan Yang, Zheng Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 481, P. 215049 - 215049

Published: Feb. 9, 2023

Language: Английский

Citations

125

Coordinating the Mechanisms of Action of Ferroptosis and the Photothermal Effect for Cancer Theranostics DOI
Fantian Zeng, Longguang Tang, Qianyu Zhang

et al.

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(13)

Published: Dec. 21, 2021

Combination therapy based on different mechanisms of cell death has shown promise in tumor therapy. However, when modalities are integrated, the maximum synergy therapeutic effects is often lacking design. Herein, we report a cancer theranostic nanomedicine formula developed by considering action ferroptosis and photothermal effect combination The croconaine molecule was encapsulated as both converter an iron-chelating agent with BSA, thus leading to biocompatible stable Cro-Fe@BSA nanoparticles (NPs). NPs milieu showed activated enhanced radical formation owing temperature-dependent Fenton reaction kinetics, while during turn prevented heat-induced heat shock proteins self-protection mechanism cells response heat. activatable photoacoustic magnetic resonance imaging performance also enabled safe reliable theranostics.

Language: Английский

Citations

121

Engineering of BODIPY-based theranostics for cancer therapy DOI
Zhiqiang Mao, Ji Hyeon Kim, Jieun Lee

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 476, P. 214908 - 214908

Published: Nov. 7, 2022

Language: Английский

Citations

101

Emerging Strategies in Stimuli-Responsive Prodrug Nanosystems for Cancer Therapy DOI
Chendi Ding, Chunbo Chen, Xiaowei Zeng

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(9), P. 13513 - 13553

Published: Sept. 1, 2022

Prodrugs are chemically modified drug molecules that inactive before administration. After administration, they converted in situ to parent drugs and induce the mechanism of action. The development prodrugs has upgraded conventional treatments terms bioavailability, targeting, reduced side effects. Especially cancer therapy, application achieved substantial therapeutic From serendipitous discovery early stage functional design with pertinence nowadays, importance is self-evident. At present, studying stimuli-responsive activation mechanisms, regulating stimuli intensity vivo, designing nanoscale prodrug formulations major strategies promote prodrugs. In this review, we provide an outlook recent cutting-edge studies on nanosystems from these three aspects. We also discuss prospects challenges future such

Language: Английский

Citations

99