Nanotechnology as a Promising Approach to Combat Multidrug Resistant Bacteria: A Comprehensive Review and Future Perspectives

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 413 - 413

Published: Jan. 31, 2023

The wide spread of antibiotic resistance has been alarming in recent years and poses a serious global hazard to public health as it leads millions deaths all over the world. sharing genes between different types bacteria led emergence multidrug resistant (MDR) microorganisms. This problem is exacerbated when microorganisms create biofilms, which can boost bacterial by up 1000-fold increase MDR infections. absence novel potent antimicrobial compounds linked rise resistance. sparked international efforts develop new improved agents well innovative efficient techniques for administration targeting. There an evolution nanotechnology treatment prevention biofilm formation infection. development nanomaterial-based therapeutics, could overcome current pathways acquired drug resistance, hopeful strategy treating difficult-to-treat Additionally, nanoparticles’ distinct size physical characteristics enable them target biofilms treat pathogens. review highlights advances combat In addition, provides insight on mechanisms XDR infection, nanoparticles their antibacterial activity. Moreover, this considers difference free antibiotics nanoantibiotics, synergistic effect nanoantibiotics planktonic bacteria, intracellular biofilm. Finally, we will discuss strength limitations application against infection future perspectives.

Language: Английский

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A Vehicle‐Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus aureus Infected Wound Healing

Advanced Science, Journal Year: 2022, Volume and Issue: 9(14)

Published: March 10, 2022

Abstract Pathogenic bacteria infection is a serious threat to human public health due the high morbidity and mortality rates. Nano delivery system for delivering antibiotics provides an alternative option improve efficiency compared conventional therapeutic agents. In addition drug loading capacity of nanocarriers, which typically around 10%, further lowers dose that pathological are exposed to. Moreover, nanocarriers not eliminated from body may cause side effects. These limitations have motivated development self‐delivery systems formed by self‐assembly different this study, vehicle‐free antimicrobial polymer polyhexamethylene biguanide (PHMB, with bactericidal anti‐biofilm functions) hybrid gold nanoparticle (Au NPs, photothermal therapy (PTT)) platform (PHMB@Au NPs) developed. This exhibits excellent synergistic effect enhance Staphylococcus aureus under near‐infrared irradiation. Furthermore, results showed PHMB@Au NPs inhibit formation biofilms, quickly remove promote wound healing through PTT in model vivo, even mediate transition macrophages M1 M2 type, accelerate tissue angiogenesis. will promising value as highly effective agents patient management.

Language: Английский

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Inorganic–organic hybrid nanomaterials for photothermal antibacterial therapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215426 - 215426

Published: Sept. 6, 2023

Language: Английский

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Recent advances in responsive hydrogels for diabetic wound healing

Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100508 - 100508

Published: Nov. 30, 2022

Poor wound healing after diabetes mellitus remains a challenging problem, and its pathophysiological mechanisms have not yet been fully elucidated. Persistent bleeding, disturbed regulation of inflammation, blocked cell proliferation, susceptible infection impaired tissue remodeling are the main features diabetic healing. Conventional dressings, including gauze, films bandages, limited function. They generally act as physical barriers absorbers exudates, which fail to meet requirements whol process. Wounds in patients typically heal slowly due hyperglycemia within bed. Once bacterial cells develop into biofilms, wounds will exhibit robust drug resistance. Recently, application stimuli-responsive hydrogels, also known "smart hydrogels", for has attracted particular attention. The basic feature this system is capacities change mechanical properties, swelling ability, hydrophilicity, permeability biologically active molecules, etc., response various stimuli, temperature, potential hydrogen (pH), protease other biological factors. Smart hydrogels can improve therapeutic efficacy limit total toxicity according characteristics wounds. In review, we summarized mechanism It hoped that work provide some inspiration suggestions research field.

Language: Английский

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Photothermal antibacterial materials to promote wound healing

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 180 - 200

Published: Sept. 27, 2023

Language: Английский

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Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14205 - 14228

Published: July 27, 2023

The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment diseases which conventional therapies present serious limitations. Additionally, NPs can drastically improve early diagnosis and follow-up many disorders. However, to harness their full capabilities, they must be precisely designed, produced, tested relevant models. Microfluidic systems simulate dynamic fluid flows, gradients, specific microenvironments, multiorgan complexes, providing an efficient cost-effective approach both synthesis screening. technologies allow under controlled conditions, enhancing batch-to-batch reproducibility. Moreover, due versatility microfluidic devices, it is possible generate customize endless platforms rapid vitro vivo screening NPs' performance. Indeed, devices show potential as advanced small organism manipulation immobilization. In this review, first we summarize major that synthesis. Next, will discuss most innovative enable mimicking environments well give insights into organism-on-a-chip promising application We conclude review with a critical assessment current challenges future directions impact field nanomedicine.

Language: Английский

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NIR‐II Photo‐Amplified Sonodynamic Therapy Using Sodium Molybdenum Bronze Nanoplatform against Subcutaneous Staphylococcus Aureus Infection

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(38)

Published: July 18, 2022

Abstract Ultrasound (US)‐mediated sonodynamic therapy (SDT) has the advantages of non‐invasiveness and deep tissue penetration. Nanosystems are prominently used in sonosensitization; however, most nano‐sonosensitizers have a low reactive oxygen species (ROS) yield, thus restraining application SDT. Sodium molybdenum bronze nanoparticles (SMB NPs) with rich vacancies developed interlayer gaps trioxide nanobelts expanded. Owing to increased vacancy density wide gap‐induced narrower band gap SMB NPs, electrons (e – ) holes (h + generated by US separated more rapidly, prevent electrons–holes recombination under irradiation. NPs exhibit second near‐infrared (NIR‐II) photothermal effect promote generation ROS sonosensitizer. The system is successfully realized eliminate Staphylococcus aureus ( S. dissipate biofilm. Therefore, multimodal using serves as an effective promising regimen for deep‐seated bacterial infections. newly Mo‐based sonosensitizer presented first time demonstrate excellent antimicrobial activity through hyperthermia‐promoting SDT therapeutics. This work proposes novel strategy field NIR‐II photo‐amplified materials eradication other important biomedical applications.

Language: Английский

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Gold nanoparticles for skin drug delivery

International Journal of Pharmaceutics, Journal Year: 2022, Volume and Issue: 625, P. 122122 - 122122

Published: Aug. 18, 2022

Language: Английский

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Dual‐Responsive Nanocomposites for Synergistic Antibacterial Therapies Facilitating Bacteria‐Infected Wound Healing

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(6)

Published: Nov. 14, 2022

Abstract The rising dangers of bacterial infections have created an urgent need for the development a new generation antibacterial technologies and therapeutics. Antibacterial photodynamic therapy (PDT), considered as noninvasive treatment with no drug resistance, has become promising photochemistry‐involved strategy. Titanium oxide (TiO 2 ) is proved to be very efficient PDT agent among photosensitive materials, while property large bandgap TiO makes it only excited by ultraviolet light, which harmful organisms. In this work, novel ligand‐to‐metal charge transfer (LMCT) mediated strategy proposed via harmless near‐infrared light irradiation. By choosing mussel‐inspired material, polydopamine (PDA) involved in forming mesoporous @PDA nanoparticles (mTiO NPs). catechol groups PDA can attach tightly even colloidal environments, also form LMCT bridge, exciting exert function 808 nm Combining sonodynamic (SDT) photothermal properties PDA, simple structure mTiO enables synergistic applications multiple functions under dual excitation NIR ultrasound. This reliable all‐in‐one NPs achieve great effect rapid repair infected wounds.

Language: Английский

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Entropy‐Mediated High‐Entropy MXenes Nanotherapeutics: NIR‐II‐Enhanced Intrinsic Oxidase Mimic Activity to Combat Methicillin‐Resistant Staphylococcus Aureus Infection

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(26)

Published: March 21, 2023

Bacterial infections, such as bacterial keratitis (BK) and subcutaneous abscess, pose significant challenges to global healthcare. Innovative new antibacterial agents strategies are in demand control infections this era of high drug resistance. Nanotechnology is gradually emerging an economically feasible effective anti-infection treatment. High-entropy MXenes (HE MXenes) used confer desirable properties with exposed active sites high-entropy atomic layers, whose potential application the field biomedicine remains be explored. Herein, monolayer HE fabricated by implementing transition metals entropy low Gibbs free energy fill gap biocatalytic performance non-high-entropy MXenes. endowed extremely strong oxidase mimic activity (Km = 0.227 mm) photothermal conversion efficiency (65.8%) second near-infrared (NIR-II) biowindow increases. Subsequently, realize NIR-II-enhanced intrinsic for killing methicillin-resistant Staphylococcus aureus rapidly removing biofilm. Furthermore, can effectively treat BK abscess infection induced nanotherapeutic minuscule side effects. Overall, demonstrate promising clinical treatment drug-resistant promote healing infected tissues.

Language: Английский

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